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News from the Gurdon Institute
06.09.16 Andrea Brand awarded Royal Society Darwin Professorship

06.09.16 Andrea Brand awarded Royal Society Darwin Professorship

The Royal Society announced today that the Gurdon Institute's Andrea Brand is one of six world-class scientists to whom they have awarded prestigious Research Professorships

06.09.16 Andrea Brand awarded Royal Society Darwin Professorship - Read More…

07.07.16 Gurdon Institute scientists reveal ultra-high resolution 3D imaging of "virtually any subcellular structure"

07.07.16 Gurdon Institute scientists reveal ultra-high resolution 3D imaging of "virtually any subcellular structure"

The culmination of a decade's research on high-resolution fluorescence imaging techniques, resulting in a dramatically increased imaging depth combined with nanoscale resolution, is presented in new Cell paper

07.07.16 Gurdon Institute scientists reveal ultra-high resolution 3D imaging of "virtually any subcellular structure" - Read More…

08.07.16 Simons lab publish findings on the cell of origin in basal cell carcinoma

08.07.16 Simons lab publish findings on the cell of origin in basal cell carcinoma

In a new Nature paper, Ben Simons and colleagues combine mathematical modelling with the study of cancer biology, proving that basal cell carcinomas arise specifically from stem cells

08.07.16 Simons lab publish findings on the cell of origin in basal cell carcinoma - Read More…

29.06.16 Watching individual cancer cells dividing and squeezing through nanotubes

29.06.16 Watching individual cancer cells dividing and squeezing through nanotubes

Jackson group postdoc Christine Schmidt's new paper in ACS Nano shows how cancer cells behave in see-through nanotubes designed to mimic blood capillaries

29.06.16 Watching individual cancer cells dividing and squeezing through nanotubes - Read More…

16.06.16 New model for stem cell self-renewal emphasises reversible states

16.06.16 New model for stem cell self-renewal emphasises reversible states

Ben Simons and Philip Greulich show that a model in which stem cells exhibit ‘dynamic heterogeneity’ can robustly explain patterns of self-renewal and differentiation, contributing to our understanding of tissue maintenance.

16.06.16 New model for stem cell self-renewal emphasises reversible states - Read More…

13.06.16 Identifying therapeutic targets in MLL among proteins that regulate gene transcription

13.06.16 Identifying therapeutic targets in MLL among proteins that regulate gene transcription

The Kouzarides lab is working with lab alumnus Mark Dawson in Australia to identify therapeutic targets in the aggressive disease Mixed-Lineage Leukaemia. They report that DOT1L works with known target BRD4 to regulate transcription of key genes.

13.06.16 Identifying therapeutic targets in MLL among proteins that regulate gene transcription - Read More…

09.06.16 Simons lab demonstrate power of statistical analysis to resolve multipotency in lineage labelling

09.06.16 Simons lab demonstrate power of statistical analysis to resolve multipotency in lineage labelling

In their Genes & Development paper, Ben Simons' group apply statistical analysis to quantify lineage tracing, and show that it is possible to resolve whether stem cells in developing tissues are multipotent.

09.06.16 Simons lab demonstrate power of statistical analysis to resolve multipotency in lineage labelling - Read More…

10.06.16 St Johnston lab probes spindle orientation in fly wing epithelium using live imaging

10.06.16 St Johnston lab probes spindle orientation in fly wing epithelium using live imaging

Live imaging in this Development paper by Dan Bergstralh et al. reveals fine details of dividing cells in the Drosophila wing disc to show that orientation of mitotic spindle does not require the protein Pins.

10.06.16 St Johnston lab probes spindle orientation in fly wing epithelium using live imaging - Read More…

03.06.16 Rick Livesey announces new spinout, Gen2

03.06.16 Rick Livesey announces new spinout, Gen2

Gurdon Institute group leader Rick Livesey announces investment from the Dementia Discovery Fund into his new spinout company Gen2 Neuroscience Ltd, which aims to develop disease-modifying drugs for dementia.

03.06.16 Rick Livesey announces new spinout, Gen2 - Read More…

12.05.16 Senior researcher Julia Tischler's microfluidics business plan reaches competition finals

12.05.16 Senior researcher Julia Tischler's microfluidics business plan reaches competition finals

Senior Research Associate Julia Tischler describes her first entrepreneurial foray, stimulated by the Cambridge Postdoc Enterprise Competition

12.05.16 Senior researcher Julia Tischler's microfluidics business plan reaches competition finals - Read More…

10.05.16  Steve Jackson wins the 2016 Dr A.H. Heineken Prize for Medicine

10.05.16 Steve Jackson wins the 2016 Dr A.H. Heineken Prize for Medicine

The Gurdon Institute's Steve Jackson, Quick Professor of Biology at the University of Cambridge and the Institute's head of Cancer Research UK Laboratories, has won the 2016 Heineken Prize for Medicine.

10.05.16 Steve Jackson wins the 2016 Dr A.H. Heineken Prize for Medicine - Read More…

25.04.16 Piddini lab find that cells compete by squeezing each other to death, offering possible clue to cancer tactic

25.04.16 Piddini lab find that cells compete by squeezing each other to death, offering possible clue to cancer tactic

Eugenia Piddini's group at the Gurdon Institute publishes a study showing that fitter cells squeeze neighbouring cells to death, making room in which to divide and expand. The paper, published in Nature Communications, may provide a clue to how cancer cells invade tissues.

25.04.16 Piddini lab find that cells compete by squeezing each other to death, offering possible clue to cancer tactic - Read More…

07.04.16 Huch lab grows pancreas organoids for new EU project to cure Type 1 diabetes

07.04.16 Huch lab grows pancreas organoids for new EU project to cure Type 1 diabetes

Meri Huch's lab is partner to an EU project, LSFM4LIFE, that aims to develop a therapy for Type 1 diabetes using human pancreatic organoids grown from stem cells

07.04.16 Huch lab grows pancreas organoids for new EU project to cure Type 1 diabetes - Read More…

04.04.16 Rawlins lab identify an active signalling mechanism that maintains quiescence in the airway epithelium

04.04.16 Rawlins lab identify an active signalling mechanism that maintains quiescence in the airway epithelium

New paper in Developmental Cell from the Rawlins lab shows that active signalling via FGFR1 is required to maintain steady-state cell turnover in airway epithelium

04.04.16 Rawlins lab identify an active signalling mechanism that maintains quiescence in the airway epithelium - Read More…

31.03.16 Sperm is epigenetically programmed to regulate embryonic genes

31.03.16 Sperm is epigenetically programmed to regulate embryonic genes

A new paper from the Gurdon lab published in Genome Research shows that sperm DNA carries epigenetic marks that influence gene transcription in the embryo

31.03.16 Sperm is epigenetically programmed to regulate embryonic genes - Read More…

31.03.16 Evolutionary progression in development of cortex modelled in vitro

31.03.16 Evolutionary progression in development of cortex modelled in vitro

The Livesey lab publish new results on modelling cortical development in vitro in 2D and 3D to explore mechanisms that control final size of the cortex in primates

31.03.16 Evolutionary progression in development of cortex modelled in vitro - Read More…

14.03.16 Launch event for the Milner Therapeutics Institute and Consortium

14.03.16 Launch event for the Milner Therapeutics Institute and Consortium

Pharmaceutical companies and academics gathered over dinner at Jesus College to launch the Milner Therapeutics Institute and Consortium

14.03.16 Launch event for the Milner Therapeutics Institute and Consortium - Read More…

23.02.16 Can organs have a sexual identity?

23.02.16 Can organs have a sexual identity?

Golnar Kolahgar from the Piddini lab comments in The Conversation on recent research suggesting that stem cells 'know' their sexual identity

23.02.16 Can organs have a sexual identity? - Read More…

04.02.16 Piddini lab find that stopping tumour cells from killing host tissues could offer new therapeutic approach

04.02.16 Piddini lab find that stopping tumour cells from killing host tissues could offer new therapeutic approach

A new paper from the Gurdon Institute's Piddini lab suggests that tumours can be prevented from growing if surrounding cells are protected from dying. This offers a potential new focus for fighting cancer by keeping host cells healthy as opposed to targeting the cancer cells to die.

04.02.16 Piddini lab find that stopping tumour cells from killing host tissues could offer new therapeutic approach - Read More…

28.01.16 Epigenetic switch discovered in obesity

28.01.16 Epigenetic switch discovered in obesity

Research by a worldwide team of scientists (including the Gurdon Institute's Azim Surani) has uncovered a regulatory, epigenetic switch that causes individuals with identical genetics to be either lean or obese.

28.01.16 Epigenetic switch discovered in obesity - Read More…

21.01.16 Surani group discover role for NANOG alone in germ cell induction

21.01.16 Surani group discover role for NANOG alone in germ cell induction

In a Letter to Nature, the Surani lab show that the transcription factor NANOG can act alone to induce primordial germ cells from mouse epiblast-like cells in culture

21.01.16 Surani group discover role for NANOG alone in germ cell induction - Read More…

20.01.16 Steve Jackson wins 2016 King Faisal International Prize

20.01.16 Steve Jackson wins 2016 King Faisal International Prize

The prestigious King Faisal International Prize for Science has been won jointly by the Gurdon Institute's Steve Jackson and Harvard Medical School's Vamsi Krishna Mootha

20.01.16 Steve Jackson wins 2016 King Faisal International Prize - Read More…

21.12.15 Discovery of new DNA modification by Magda Koziol in the Gurdon lab

21.12.15 Discovery of new DNA modification by Magda Koziol in the Gurdon lab

A paper authored by the Gurdon lab's Magda Koziol in Nature Structural and Molecular Biology suggests that DNA modifications are more diverse than previously thought.

21.12.15 Discovery of new DNA modification by Magda Koziol in the Gurdon lab - Read More…

17.12.15 Miska lab in research team finding evidence for sympatric speciation in fish

17.12.15 Miska lab in research team finding evidence for sympatric speciation in fish

Milan Malinsky from the Miska lab is part of research team finding evidence for sympatric speciation in cichlid fish in Africa's Lake Massoko; published in Science, 18 December 2015 issue.

17.12.15 Miska lab in research team finding evidence for sympatric speciation in fish - Read More…

16.12.15 How close are we to successfully editing genes in human embryos?

16.12.15 How close are we to successfully editing genes in human embryos?

Azim Surani writes for The Conversation on whether germline research is sufficiently advanced to be combined with new gene editing technology

16.12.15 How close are we to successfully editing genes in human embryos? - Read More…

11.12.15 NICE approves olaparib (Lynparza) for use by the NHS

11.12.15 NICE approves olaparib (Lynparza) for use by the NHS

NICE has approved olaparib for use by the NHS for certain ovarian cancer patients, bringing the drug to around 400 women per year in England and Wales

11.12.15 NICE approves olaparib (Lynparza) for use by the NHS - Read More…