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25.10.16 Synthetic-lethal combination of PAXX and XLF loss in mammalian development

25.10.16 Synthetic-lethal combination of PAXX and XLF loss in mammalian development

In this Genes & Development paper, the Jackson group and colleagues demonstrate the combined lethality of PAXX and XLF gene knockouts

25.10.16 Synthetic-lethal combination of PAXX and XLF loss in mammalian development - Read More…

13.11.16  Meri Huch wins Hamdan Award for Medical Research Excellence 2015-2016

13.11.16 Meri Huch wins Hamdan Award for Medical Research Excellence 2015-2016

Gurdon Institute Group Leader Meri Huch has won a prestigious prize from the Dubai-based Sheikh Hamdan bin Rashid al Maktoum Award for Medical Sciences

13.11.16 Meri Huch wins Hamdan Award for Medical Research Excellence 2015-2016 - Read More…

31.10.16 Jackson group demonstrate how haploid ES cells can provide new genetic screening platform

31.10.16 Jackson group demonstrate how haploid ES cells can provide new genetic screening platform

This Nature Chemical Biology publication from Steve Jackson's group reveals a genetic screening platform based on haploid embryonic stem cells

31.10.16 Jackson group demonstrate how haploid ES cells can provide new genetic screening platform - Read More…

25.10.16 Ahringer lab study of chromatin domains finds separation of genes with different functions

25.10.16 Ahringer lab study of chromatin domains finds separation of genes with different functions

This PNAS paper shows that the higher-order structure of chromatin exhibits domains separating broadly-expressed genes from those that are developmentally regulated

25.10.16 Ahringer lab study of chromatin domains finds separation of genes with different functions - Read More…

18.10.16 Emma Rawlins' group shows that extrinsic signals drive lung epithelial cell fate

18.10.16 Emma Rawlins' group shows that extrinsic signals drive lung epithelial cell fate

In this Development paper, the Rawlins group with colleagues in Edinburgh investigate the mechanisms controlling the fate of developing lung epithelial cells

18.10.16 Emma Rawlins' group shows that extrinsic signals drive lung epithelial cell fate - Read More…

06.09.16 Andrea Brand awarded Royal Society Darwin Professorship

06.09.16 Andrea Brand awarded Royal Society Darwin Professorship

The Royal Society announced today that the Gurdon Institute's Andrea Brand is one of six world-class scientists to whom they have awarded prestigious Research Professorships

06.09.16 Andrea Brand awarded Royal Society Darwin Professorship - Read More…

07.07.16 Gurdon Institute scientists reveal ultra-high resolution 3D imaging of "virtually any subcellular structure"

07.07.16 Gurdon Institute scientists reveal ultra-high resolution 3D imaging of "virtually any subcellular structure"

The culmination of a decade's research on high-resolution fluorescence imaging techniques, resulting in a dramatically increased imaging depth combined with nanoscale resolution, is presented in new Cell paper

07.07.16 Gurdon Institute scientists reveal ultra-high resolution 3D imaging of "virtually any subcellular structure" - Read More…

08.07.16 Simons lab publish findings on the cell of origin in basal cell carcinoma

08.07.16 Simons lab publish findings on the cell of origin in basal cell carcinoma

In a new Nature paper, Ben Simons and colleagues combine mathematical modelling with the study of cancer biology, proving that basal cell carcinomas arise specifically from stem cells

08.07.16 Simons lab publish findings on the cell of origin in basal cell carcinoma - Read More…

29.06.16 Watching individual cancer cells dividing and squeezing through nanotubes

29.06.16 Watching individual cancer cells dividing and squeezing through nanotubes

Jackson group postdoc Christine Schmidt's new paper in ACS Nano shows how cancer cells behave in see-through nanotubes designed to mimic blood capillaries

29.06.16 Watching individual cancer cells dividing and squeezing through nanotubes - Read More…

16.06.16 New model for stem cell self-renewal emphasises reversible states

16.06.16 New model for stem cell self-renewal emphasises reversible states

Ben Simons and Philip Greulich show that a model in which stem cells exhibit ‘dynamic heterogeneity’ can robustly explain patterns of self-renewal and differentiation, contributing to our understanding of tissue maintenance.

16.06.16 New model for stem cell self-renewal emphasises reversible states - Read More…

13.06.16 Identifying therapeutic targets in MLL among proteins that regulate gene transcription

13.06.16 Identifying therapeutic targets in MLL among proteins that regulate gene transcription

The Kouzarides lab is working with lab alumnus Mark Dawson in Australia to identify therapeutic targets in the aggressive disease Mixed-Lineage Leukaemia. They report that DOT1L works with known target BRD4 to regulate transcription of key genes.

13.06.16 Identifying therapeutic targets in MLL among proteins that regulate gene transcription - Read More…

09.06.16 Simons lab demonstrate power of statistical analysis to resolve multipotency in lineage labelling

09.06.16 Simons lab demonstrate power of statistical analysis to resolve multipotency in lineage labelling

In their Genes & Development paper, Ben Simons' group apply statistical analysis to quantify lineage tracing, and show that it is possible to resolve whether stem cells in developing tissues are multipotent.

09.06.16 Simons lab demonstrate power of statistical analysis to resolve multipotency in lineage labelling - Read More…

10.06.16 St Johnston lab probes spindle orientation in fly wing epithelium using live imaging

10.06.16 St Johnston lab probes spindle orientation in fly wing epithelium using live imaging

Live imaging in this Development paper by Dan Bergstralh et al. reveals fine details of dividing cells in the Drosophila wing disc to show that orientation of mitotic spindle does not require the protein Pins.

10.06.16 St Johnston lab probes spindle orientation in fly wing epithelium using live imaging - Read More…

03.06.16 Rick Livesey announces new spinout, Gen2

03.06.16 Rick Livesey announces new spinout, Gen2

Gurdon Institute group leader Rick Livesey announces investment from the Dementia Discovery Fund into his new spinout company Gen2 Neuroscience Ltd, which aims to develop disease-modifying drugs for dementia.

03.06.16 Rick Livesey announces new spinout, Gen2 - Read More…

12.05.16 Senior researcher Julia Tischler's microfluidics business plan reaches competition finals

12.05.16 Senior researcher Julia Tischler's microfluidics business plan reaches competition finals

Senior Research Associate Julia Tischler describes her first entrepreneurial foray, stimulated by the Cambridge Postdoc Enterprise Competition

12.05.16 Senior researcher Julia Tischler's microfluidics business plan reaches competition finals - Read More…

10.05.16  Steve Jackson wins the 2016 Dr A.H. Heineken Prize for Medicine

10.05.16 Steve Jackson wins the 2016 Dr A.H. Heineken Prize for Medicine

The Gurdon Institute's Steve Jackson, Quick Professor of Biology at the University of Cambridge and the Institute's head of Cancer Research UK Laboratories, has won the 2016 Heineken Prize for Medicine.

10.05.16 Steve Jackson wins the 2016 Dr A.H. Heineken Prize for Medicine - Read More…

25.04.16 Piddini lab find that cells compete by squeezing each other to death, offering possible clue to cancer tactic

25.04.16 Piddini lab find that cells compete by squeezing each other to death, offering possible clue to cancer tactic

Eugenia Piddini's group at the Gurdon Institute publishes a study showing that fitter cells squeeze neighbouring cells to death, making room in which to divide and expand. The paper, published in Nature Communications, may provide a clue to how cancer cells invade tissues.

25.04.16 Piddini lab find that cells compete by squeezing each other to death, offering possible clue to cancer tactic - Read More…

07.04.16 Huch lab grows pancreas organoids for new EU project to cure Type 1 diabetes

07.04.16 Huch lab grows pancreas organoids for new EU project to cure Type 1 diabetes

Meri Huch's lab is partner to an EU project, LSFM4LIFE, that aims to develop a therapy for Type 1 diabetes using human pancreatic organoids grown from stem cells

07.04.16 Huch lab grows pancreas organoids for new EU project to cure Type 1 diabetes - Read More…

04.04.16 Rawlins lab identify an active signalling mechanism that maintains quiescence in the airway epithelium

04.04.16 Rawlins lab identify an active signalling mechanism that maintains quiescence in the airway epithelium

New paper in Developmental Cell from the Rawlins lab shows that active signalling via FGFR1 is required to maintain steady-state cell turnover in airway epithelium

04.04.16 Rawlins lab identify an active signalling mechanism that maintains quiescence in the airway epithelium - Read More…

31.03.16 Sperm is epigenetically programmed to regulate embryonic genes

31.03.16 Sperm is epigenetically programmed to regulate embryonic genes

A new paper from the Gurdon lab published in Genome Research shows that sperm DNA carries epigenetic marks that influence gene transcription in the embryo

31.03.16 Sperm is epigenetically programmed to regulate embryonic genes - Read More…

31.03.16 Evolutionary progression in development of cortex modelled in vitro

31.03.16 Evolutionary progression in development of cortex modelled in vitro

The Livesey lab publish new results on modelling cortical development in vitro in 2D and 3D to explore mechanisms that control final size of the cortex in primates

31.03.16 Evolutionary progression in development of cortex modelled in vitro - Read More…

14.03.16 Launch event for the Milner Therapeutics Institute and Consortium

14.03.16 Launch event for the Milner Therapeutics Institute and Consortium

Pharmaceutical companies and academics gathered over dinner at Jesus College to launch the Milner Therapeutics Institute and Consortium

14.03.16 Launch event for the Milner Therapeutics Institute and Consortium - Read More…

23.02.16 Can organs have a sexual identity?

23.02.16 Can organs have a sexual identity?

Golnar Kolahgar from the Piddini lab comments in The Conversation on recent research suggesting that stem cells 'know' their sexual identity

23.02.16 Can organs have a sexual identity? - Read More…

04.02.16 Piddini lab find that stopping tumour cells from killing host tissues could offer new therapeutic approach

04.02.16 Piddini lab find that stopping tumour cells from killing host tissues could offer new therapeutic approach

A new paper from the Gurdon Institute's Piddini lab suggests that tumours can be prevented from growing if surrounding cells are protected from dying. This offers a potential new focus for fighting cancer by keeping host cells healthy as opposed to targeting the cancer cells to die.

04.02.16 Piddini lab find that stopping tumour cells from killing host tissues could offer new therapeutic approach - Read More…