#MedSciLife campaign celebrates benefits of pursuits away from the research bench
First positive randomised trial to evaluate the efficacy of a PARP inhibitor beyond ovarian cancer
30.01.17 Surani lab with Institut Curie colleagues probe Xist-mediated gene silencing in early embryogenesis
Analysing Xist-mutant embryos down to single-cell RNA sequencing, the Surani and Heard (Institut Curie) labs examine the epigenetic process of X-chromosome inactivation
30.01.17 Simons lab and colleagues identify stem cells that generate branching ducts in mammary gland
Nature paper describes how stem cell behaviour underlies branching morphogenesis in the mammary gland
Di Fiore et al. from the Pines lab identify conserved sequence motifs that mediate inhibition of active APC/C
Wellcome announce the renewal of the Gurdon Institute's core funding along with that of neighbouring Stem Cell Institute
In this Genes & Development paper, the Jackson group and colleagues demonstrate the combined lethality of PAXX and XLF gene knockouts
Gurdon Institute Group Leader Meri Huch has won a prestigious prize from the Dubai-based Sheikh Hamdan bin Rashid al Maktoum Award for Medical Sciences
31.10.16 St Johnston lab use super-resolution microscopy and live imaging to track movement of bicoid mRNA in fruit fly eggs
This eLife study shows how random active transport and anterior anchoring create the gradient of bicoid mRNA in the Drosophila oocyte
This Nature Chemical Biology publication from Steve Jackson's group reveals a genetic screening platform based on haploid embryonic stem cells
This PNAS paper shows that the higher-order structure of chromatin exhibits domains separating broadly-expressed genes from those that are developmentally regulated
In this Development paper, the Rawlins group with colleagues in Edinburgh investigate the mechanisms controlling the fate of developing lung epithelial cells
Steve Jackson's lab pin down further events in the DNA repair pathway in this Nature Communications paper
The Royal Society announced today that the Gurdon Institute's Andrea Brand is one of six world-class scientists to whom they have awarded prestigious Research Professorships
Targeting epigenetic regulators in combination with DNA-damaging agents may offer new selective anti-cancer strategy
22.08.16 Simons lab reveal that imbalanced cell fate, rather than faster cell division, drives cancer development in oesophagus
Publishing in Nature Cell Biology with colleagues from the Sanger Institute, the Simons lab show that subtle changes in cell fate behaviour underlie tumour development
11.07.16 Molecular duo of Patronin and Shot are crucial for polarising microtubules, find St Johnston lab
A new protein complex, Patronin and Shot, is found to support the organisation of microtubules that lead to cell polarisation
07.07.16 Gurdon Institute scientists reveal ultra-high resolution 3D imaging of "virtually any subcellular structure"
The culmination of a decade's research on high-resolution fluorescence imaging techniques, resulting in a dramatically increased imaging depth combined with nanoscale resolution, is presented in new Cell paper
In a new Nature paper, Ben Simons and colleagues combine mathematical modelling with the study of cancer biology, proving that basal cell carcinomas arise specifically from stem cells
Jackson group postdoc Christine Schmidt's new paper in ACS Nano shows how cancer cells behave in see-through nanotubes designed to mimic blood capillaries
28.06.16 Storm Therapeutics, the latest spinout from the Gurdon Institute, raises investment of £12 M
Tony Kouzarides' and Eric Miska's spinout from the Gurdon Institute seeks to find new cancer therapeutic targets among RNA-modifying enzymes
Ben Simons and Philip Greulich show that a model in which stem cells exhibit ‘dynamic heterogeneity’ can robustly explain patterns of self-renewal and differentiation, contributing to our understanding of tissue maintenance.
The Kouzarides lab is working with lab alumnus Mark Dawson in Australia to identify therapeutic targets in the aggressive disease Mixed-Lineage Leukaemia. They report that DOT1L works with known target BRD4 to regulate transcription of key genes.
09.06.16 Simons lab demonstrate power of statistical analysis to resolve multipotency in lineage labelling
In their Genes & Development paper, Ben Simons' group apply statistical analysis to quantify lineage tracing, and show that it is possible to resolve whether stem cells in developing tissues are multipotent.
Live imaging in this Development paper by Dan Bergstralh et al. reveals fine details of dividing cells in the Drosophila wing disc to show that orientation of mitotic spindle does not require the protein Pins.
Gurdon Institute group leader Rick Livesey announces investment from the Dementia Discovery Fund into his new spinout company Gen2 Neuroscience Ltd, which aims to develop disease-modifying drugs for dementia.
Senior Research Associate Julia Tischler describes her first entrepreneurial foray, stimulated by the Cambridge Postdoc Enterprise Competition
The Gurdon Institute's Steve Jackson, Quick Professor of Biology at the University of Cambridge and the Institute's head of Cancer Research UK Laboratories, has won the 2016 Heineken Prize for Medicine.
25.04.16 Piddini lab find that cells compete by squeezing each other to death, offering possible clue to cancer tactic
Eugenia Piddini's group at the Gurdon Institute publishes a study showing that fitter cells squeeze neighbouring cells to death, making room in which to divide and expand. The paper, published in Nature Communications, may provide a clue to how cancer cells invade tissues.
Meri Huch's lab is partner to an EU project, LSFM4LIFE, that aims to develop a therapy for Type 1 diabetes using human pancreatic organoids grown from stem cells