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Eric Miska

miskaEric Miska PhD, Herchel Smith Professor of Molecular Genetics, Cancer Research UK Senior Research Fellow, Member of the Genetics Department.

Miska Group website | Europe PMC | Pubmed




Non-coding RNA and genome dynamics

miska 2013microRNAs (miRNAs), a large class of short non- coding RNAs found in many plants and animals, often act to inhibit gene expression post-transcriptionally. Approximately 3% of all known human genes encode miRNAs. Important functions for miRNAs in animal development and physiology are emerging. A number of miRNAs have been directly implicated in human disease. We have generated loss-of-function mutations in almost all of the 112 known miRNA genes in the nematode Caenorhabditis elegans.This collection provides the only comprehensive resource for the genetic analysis of individual miRNAs to date. Our main goal is to understand the genetic networks underlying miRNA-dependent control of development.

We are also studying other short RNA (sRNA) species, their biology and mechanism of action. For example, we recently identified the piRNAs of C elegans. piRNAs are required for germline development and maintenance in worms, flies and mammals. Neither the biogenesis nor the mechanism of action is understood for this class of small RNAs.We are using genetic screens, biochemical and molecular biology approaches to address basic questions about sRNA biology. Of particular interest is how small RNA regulatory networks interact with the genome and the environment.

In addition, we have developed tools for the analysis of miRNA expression in human disease and have discovered miRNAs that have potential as molecular markers for diagnosis and prognosis.


Selected publications:

• Lehrbach N, Armisen J, Lightfoot H, Murfitt K, Bugaut A, Balasubramanian S, Miska EA (2009) LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nature Struct Mol Biology, 16, 1016-1022

• Lehrbach NJ, Castro C, Murfitt KJ, Abreu-Goodger C, Griffin JL and Miska EA (2012) Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans. RNA,18, 2220 - 2235

• Ashe A, Sapetschnig A, Weick EM, Mitchell J, Bagijn MP, Cording AC, Doebley AL, Goldstein LD, Lehrbach NJ, Le Pen J, Pintacuda G, Sakaguchi A, Sarkies P, Ahmed S and Miska EA (2012) piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans. Cell, 150, 88 - 99


Plain English

My laboratory is investigating how cells decide to divide to generate all the cells of the body, to become different from each other to form different tissues such as muscle brain or blood. If cells get these decisions wrong, cancer may be the consequence. Our particular focus is a class of small regulatory genes (microRNAs) that act like molecular switches and control many aspects of development and are likely directly involved in human cancer. To better understand the biology of microRNAs we are studying a very simple animal, the roundworm Caenorhabditis elegans, as well as human cancer cells.


Alper Akay • Fabian Braukmann • Ahmet Can Berkyurek • Isabela Cunha Navarro • Tomas di Domenico • Mingliu Du • Katharina Gapp • Tanay Ghosh • Sabrina Huber • Maximilian Jakobs • David Jordan • Asia Kosalka • Miranda Landgraf • Jérémie le Pen • Milan Malinsky • Eyal Maori • Wayo Matsushima • Anna Protasis • Cristian Riccio • Marc Ridyard • Konrad Rudolph • Alexandra Sapetschnig • Kin Man Suen • Mélanie Tanguy • Gregoire Vernaz • Omer Ziv