Jackson SP and Jeggo PA. (1995) DNA double-strand break repair, V(D)J recombination, and the involvement of DNA-PK. Trends Biochem. Sci. 20, 412-415.

Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.