White RJ, Khoo BC-E, Inostroza JA, Reinberg D and Jackson SP. (1994) The TBP-binding repressor Dr1 differentially regulates RNA polymerases I, II, and III. Science 266, 448-450.

RNA polymerases I, II, and III each use the TATA-binding protein (TBP). Regulators that target this shared factor may therefore provide a means to coordinate the activities of the three nuclear RNA polymerases; The repressor Dr1 binds to TBP and blocks the interaction of TBP with polymerase II- and polymerase III-specific factors. This enables Drl to coordinately regulate transcription by RNA polymerases II and III, Under the same conditions, Dr1 does not inhibit polymerase I transcription. By selectively repressing polymerases II and III, Drl may shift the physiological balance of transcriptional output in favor of polymerase I.