Publications
Most recent-2010, 2009-2005, 2004-2000, 1999-1995, 1994-1990
*UKPMC - link to free full text research articles
Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, Britton S, Oelschlaegel T, Xhemalce B, Balasubramanian S, Jackson SP (2012) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. Feb 5 [Epub ahead of print] Abstract Full text
Miller KM, Rodriguez R (2011) G-quadruplexes: selective DNA targeting for cancer therapeutics? Expert Rev Clin Pharmacol. 4(2), 139-42. Editorial No abstract available. Full text
Qvist P, Huertas P, Jimeno S, Nyegaard M, Hassan MJ, Jackson SP, Børglum AD (2011) CtIP mutations cause Seckel and Jawad syndromes. PLoS Genetics 7(10): e1002310. Abstract Full text UKPMC
Forment JV, Blasius M, Guerini I, Jackson SP (2011) Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation. PLoS ONE 6(8): e23517. Abstract Full text UKPMC
Blasius M, Forment JV, Thakkar N, Wagner SA, Choudhary C, Jackson SP. (2011) A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1. Genome Biol. Aug 18;12(8):R78. Abstract Full text UKPMC
Flott S, Kwon Y, Pigli YZ, Rice PA, Sung P, and Jackson SP. (2011) Regulation of Rad51 function by phosphorylation. EMBO Rep. 12(8), 833-9 Abstract Full text UKPMC
Harrigan JA, Belotserkovskaya R, Coates J, Dimitrova DS, Polo SE, Bradshaw CR, Fraser P, and Jackson SP. (2011) Replication stress induces 53BP1-containing OPT domains in G1 cells. J. Cell Biol.193(1), 97-108 Abstract Full text UKPMC
Giunta S and Jackson SP. (2011) Give me a break, but not in mitosis: The mitotic DNA damage response marks DNA double strand breaks with early signaling events. Cell Cycle 10(8), 1-7. Abstract Full text UKPMC
Polo SE and Jackson SP. (2011) Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev. 25, 409-433. Abstract Full text UKPMC
Kaidi A, Weinert BT, Choudhary C, Jackson SP. (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329, 1348-1353. Abstract Full text Reprint
Miller KM, Tjeertes JV, Coates J, Legube G, Polo SE, Britton S, Jackson SP. (2010) Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol. 17, 1144-51. Abstract Full text UKPMC
Polo SE, Kaidi A, Baskcomb L, Galanty Y, Jackson SP. (2010) Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J. 29, 3130-9. Abstract Full text UKPMC
Giunta S, Belotserkovskaya R, Jackson SP. (2010) DNA damage signaling in response to double-strand breaks during mitosis. J Cell Biol. 190, 197-207. Abstract Full text UKPMC
Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA. (2010) Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science 329, 78-82. Abstract Full text
Miller KM. (2010) Advances in understanding genome maintenance. Genome Biology 11, 301. Abstract Full text
Huertas P. (2010) DNA resection in eukaryotes: deciding how to fix the break. Nat Struct Mol Biol. 17, 11-16. Abstract Full text UKPMC
Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP. (2009) Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature 462, 935-9. Abstract Full text UKPMC
Morris JR, Boutell C, Keppler M, Densham R, Weekes D, Alamshah A, Butler L, Galanty Y, Pangon L, Kiuchi T, Ng T, Solomon E. (2009) The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature 462, 886-90. Abstract Full text
Townsend K, Dyson H, Blackford AN, Miller ES, Chapman JR, Sedgwick GG, Barone G, Turnell AS, Stewart GS. (2009) Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. J Biol Chem. 284, 33939-48. Abstract Full text UKPMC
Jackson SP and Bartek J. (2009) The DNA damage response in human biology and disease. Nature 461, 1071-1078. Abstract Full text UKPMC
Lloyd J*, Chapman JR*, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP^, Smerdon SJ^. (2009) A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell 139, 100-11. *These authors contributed equally to this work. ^Co-corresponding authors. Abstract Full text UKPMC
Ahel D, Horejsi Z*, Wiechens N*, Polo SE*, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ. (2009) Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1. Science 325, 1240-3. *These authors contributed equally to this work. Abstract Full text
Jackson SP. (2009) The DNA-damage response: new molecular insights and new approaches to cancer therapy. Biochem Soc Trans. 37(Pt 3):483-94. Abstract Full text UKPMC
Tjeertes JV*, Miller KM*, Jackson SP. (2009) Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J. 28, 1878-1889. *These authors contributed equally to this work. Abstract Full text UKPMC
Enge M, Bao W, Hedström E, Jackson SP, Moumen A, Selivanova G. (2009) MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell 15(3):171-83. Abstract Full text
Huertas P, Jackson SP. (2009) Human CtIP mediates cell-cycle control of DNA-end resection and double-strand-break repair. J Biol Chem. 284:9558-9565. Abstract Full text UKPMC
Sollier J, Driscoll R, Castellucci F, Foiani M, Jackson SP, Branzei D. (2009) The S. cerevisiae Esc2 and Smc5-6 Proteins Promote Sister Chromatid Junction Mediated Intra-S Repair. Mol Biol Cell 20(6):1671-82. Abstract Full text UKPMC
Gravel S, Chapman JR, Magill C, Jackson SP. (2008) DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev. 22: 2767-2772. Abstract Full text UKPMC
Huertas P, Cortés-Ledesma F, Sartori AA, Aguilera A, Jackson SP. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455: 689-692. Abstract Full text UKPMC
Chapman JR, Jackson SP. (2008) Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep. 9(8):795-801. Abstract Full text UKPMC
Dry KL, Jackson SP. (2008) Maintenance of genome stability. Abcam online article. Full text
Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. (2007) Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair. Mol Cell. 28(6):1045-57. Abstract Full text UKPMC
Li Y, Chirgadze DY, Bolanos-Garcia VM, Sibanda BL, Davies OR, Ahnesorg P, Jackson SP, Blundell TL. (2008) Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ. EMBO J. 27:290-300. Abstract Full text UKPMC
*Kolas NK, *Chapman JR, *Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D. (2007) Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase. Science 318, 1637-1640. *These authors contributed equally to this work Abstract Full text UKPMC
Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J and Jackson SP. (2007) Human CtIP promotes DNA end resection. Nature 450, 509-514. Abstract Full text UKPMC
Hammet A, Magill C, Heierhorst J, Jackson SP. (2007) Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Rep. 8(9):851-857. Abstract Full text UKPMC
Bartkova J, Horej Sbreve I Z, Sehested M, Nesland JM, Rajpert-De Meyts E, Skakkebaek NE, Stucki M, Jackson S, Lukas J, Bartek J. (2007) DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene 26(53):7414-7422. Abstract Full text
Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A. (2007) Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med. 204(5):1003-11. Abstract Full text UKPMC
Meier A, Fiegler H, Munoz P, Ellis P, Rigler D, Langford C, Blasco MA, Carter N, Jackson SP. (2007) Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres. EMBO J. 26(11):2707-2718. Abstract Full text UKPMC
Xhemalce B, Miller KM, Driscoll R, Masumoto H, Jackson SP, Kouzarides T, Verreault A, Arcangioli B. (2007) Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe. J Biol Chem. 282:15040-15047. Abstract Full text UKPMC
Driscoll R, Hudson A and Jackson SP. (2007) Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science 315:649-652. Abstract Full text
Ahnesorg P and Jackson SP. (2007) The non-homologous end-joining protein Nej1p is a target of the DNA damage checkpoint. DNA Repair (Amst) 6(2):190-201. Abstract Full text
Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, Pappin D, Khanna KK, Jackson SP, Sutherland RL, Watts CK. (2006) EDD mediates DNA damage-induced activation of CHK2. J Biol Chem. 281(52):39990-40000. Abstract Full text
Hentges P, Ahnesorg P, Pitcher RS, Bruce CK, Kysela B, Green AJ, Bianchi J, Wilson TE, Jackson SP, Doherty AJ. (2006) Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos. J Biol Chem. 281(49):37517-26. Abstract Full text
McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, Giavara S, O'connor MJ, Tutt AN, Zdzienicka MZ, Smith GC, Ashworth A. (2006) Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition. Cancer Res. 66(16):8109-15. Abstract Full text
Grenon M, Magill CP, Lowndes NF, Jackson SP. (2006) Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation. FEMS Yeast Research 6(5):836-847. Abstract Full text
Stucki M, Jackson SP. (2006) gammaH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst.) 5(5):534-543. Abstract Full text
Ahnesorg P, Smith P, Jackson SP. (2006) XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining. Cell 124(2):301-13. Abstract Full text
Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL. (2006) Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. DNA Repair 5(3):362-8 Abstract Full text
Smits VA*, Reaper PM*, Jackson SP. (2006) Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response. Curr Biol. 16(2):150-159 *These authors contributed equally to this work Abstract Full text
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP. (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol. 8(1):37-45. Abstract Full text
Tutt AN, Lord CJ, McCabe N, Farmer H, Turner N, Martin NM, Jackson SP, Smith GC, Ashworth A. (2005) Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. Cold Spring Harb Symp Quant Biol. 70:139-48. Abstract Full text
Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. (2005) MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks. Cell 123(7):1213-26. Abstract Full text
Moumen A, Masterson P, O'Connor M, Jackson SP. (2005) hnRNP K: a new HDM2 target and co-activator for p53-dependent transcription in response to DNA damage. Cell 123(6):1065-1078. Abstract Full text
Short SC, Bourne S, Martindale C, Woodcock M, Jackson SP. (2005) DNA damage responses at low radiation doses. Radiat Res. 164(3):292-302. Abstract Full text
Sartori A. (2005) Networking in the Framework. Nature 437(7056):292. No abstract available. Full text
Lau A, Swinbank KM, Ahmed PS, Taylor DL, Jackson SP, Smith GC, O'Connor MJ. (2005) Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat Cell Biol. 7(5):493-500. Abstract Full text
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A. (2005) Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434(7035):917-21. Abstract Full text
Harvey AC, Jackson SP, Downs JA. (2005) Saccharomyces cerevisiae Histone H2A Ser122 facilitates DNA repair. Genetics 170:543-553. Abstract Full text
Falck J, Coates J, Jackson SP. (2005) Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434:605-611. Abstract Full text
Giavara S, Kosmidou E, Hande MP, Bianchi ME, Morgan A, d'Adda di Fagagna F, Jackson SP. (2005) Yeast Nhp6A/B and Mammalian Hmgb1 Facilitate the Maintenance of Genome Stability. Curr Biol. 15(1):68-72. Abstract Full text
Lee AC, Fernandez-Capetillo O, Pisupati V, Jackson SP, Nussenzweig A. (2005) Specific Association of Mouse MDC1/NFBD1 with NBS1 at Sites of DNA- Damage. Cell Cycle. 4(1): 177-182. Abstract Full text
Zglinicki T, Saretzki G, Ladhoff J, d'Adda di Fagagna F, Jackson SP. (2005) Human cell senescence as a DNA damage response. Mech Ageing Dev. Jan;126(1):111-7. Abstract Full text
Downs JA, Allard S, Jobin-Robitaille O, Javaheri A, Auger A, Bouchard N, Kron SJ, Jackson SP, Cote J. (2004) Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites. Mol Cell. 16(6):979-90. Abstract Full text
Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. (2004) Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM. Cancer Res. 64(24):9152-9. Abstract Full text
Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ, Reis C, Dahm K, Fricke A, Krempler A, Parker AR, Jackson SP, Gennery A, Jeggo PA, Lobrich M. (2004) A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to gamma-H2AX Foci. Mol Cell. 16(5):715-24. Abstract Full text
Squires S, Coates JA, Goldberg M, Toji LH, Jackson SP, Clarke DJ, Johnson RT. (2004) p53 Prevents the Accumulation of Double-Strand DNA Breaks at Stalled-Replication Forks Induced by UV in Human Cells. Cell Cycle 3(12):1543-1557. Abstract Full text
Lau A, Kanaar R, Jackson SP, O'Connor MJ. (2004) Suppression of retroviral infection by the RAD52 DNA repair protein. EMBO J. 23(16):3421-9. Abstract Full text
Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J. (2004) Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J 23:2674-2683. Abstract Full text
Jones GG, Reaper PM, Pettitt AR, Sherrington PD. (2004) The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes. Oncogene 23(10):1911-21. Abstract Full text
Jazayeri A, McAinsh AD, Jackson SP. (2004) Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair. Proc. Natl Acad. Sci. USA 101(6):1644-9. Abstract Full text
Roy R, Meier B, McAinsh AD, Feldmann HM and Jackson SP. (2004) Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing. J. Biol. Chem 279(1):86-94. Abstract Full text
Stucki M, Jackson SP. (2004) Tudor domains track down DNA breaks. Nat Cell Biol. Dec;6(12):1150-2. Abstract Full textd'Adda di Fagagna F, Teo SH, Jackson SP. (2004) Functional links between telomeres and proteins of the DNA-damage response. Genes Dev. 18:1781-1799. Abstract Full text
Harvey AC, Downs JA. (2004) What functions do linker histones provide? Mol Microbiol. Aug;53(3):771-5. Abstract Full text
Stucki M, Jackson SP. (2004) MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes. DNA Repair (Amst). Aug-Sep;3(8-9):953-7. Abstract Full text
Surralles J, Jackson SP, Jasin M, Kastan MB, West SC, Joenje H. (2004) Molecular cross-talk among chromosome fragility syndromes. Genes Dev. Jun 15;18(12):1359-70. Meeting review. Full text
Reaper PM, d'Adda di Fagagna F, Jackson SP. (2004) Activation of the DNA damage response by telomere attrition. Cell Cycle 3(5):543-546. Abstract Full text
Downs JA, Jackson SP. (2004) A means to a DNA end: the many roles of Ku. Nat Rev Mol Cell Biol. 5(5):367-78. Abstract Full text
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP. and Jackson SP. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426(6963):194-8. Abstract Full text
Downs JA, Kosmidou E, Morgan A and Jackson SP. (2003) Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol. Cell 11:1685-1692. Abstract Full text
*Goldberg M, *Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J and Jackson SP. (2003) The MDC1 protein is required for the intra-S-phase DNA damage checkpoint. Nature 421:952-956. *These authors contributed equally to this work Abstract Full text
d'Adda di Fagagna F, Weller GR, Doherty AJ and Jackson SP. (2003) The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku. EMBO Reports 4:47-52. Abstract Full text
Dionne I, Nookala RK, Jackson SP, Doherty AJ and Bell SD. (2003) A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus. Mol. Cell 11:275-282 Abstract Full text
Gravel S, Jackson SP. (2003) Increased genome instability in aging yeast. Cell 115(1):1-2. Abstract Full text
Downs JA and Jackson SP. (2003) Protective packaging for DNA. Nature 424:732-734. Abstract Full text
Smith GCM and Jackson SP. (2003) The PIKK family of protein kinases. Handbook of Cell Signalling 1:557-561 (Academic Press).
Bradbury JM and Jackson SP. (2003) Double-strand break recognition and its repair by nonhomologous end joining. Handbook of Cell Signalling 3:219-224 (Academic Press). Abstract
Bradbury JM and Jackson SP. (2003) Quick Guide: ATM and ATR. Curr. Biol. 13:R468. Full text
Bradbury JM and Jackson SP. (2003) The complex matter of DNA double-strand break detection. Biochem. Soc. Trans 31:40-44. Abstract Full text
*Weller GR, *Kysela B, *Roy R, Tonkin L, Scanlan E, Della M, Krogh Devine S, Day JP, Wilkinson A, d'Adda di Fagagna F, Devine K, Bowater RP, Jeggo P, Jackson SP and Doherty AJ. (2002) Identification of a DNA non-homologous end-joining complex in bacteria. Science 297:1686-1689. *These authors contributed equally to this work Abstract Full text
Chang J-H, Kim H-C, Hwang K-Y, Lee J-W, Jackson SP, Bell SD and Cho Y. (2002) Structural basis for the NAD dependent deacetylase mechanism of Sir2. J. Biol. Chem. 277:34489-34498. Abstract Full text
Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP and Smerdon SJ. (2002) Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol. Cell 9:1045-1054. Abstract Full text
Bell SD, Botting CH, Wardleworth BN, Jackson SP and White MF. (2002) Alba, a conserved archaeal chromatin protein, interacts with Sir2 and is regulated by acetylation. Science 296:148-151. Abstract Full text
Rouse J and Jackson SP. (2002) Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol. Cell 9:857-869. Abstract Full text
Rouse J and Jackson SP. (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297:547-551. Abstract Full text
Jackson SP. (2002) Sensing and repairing DNA double-strand breaks. Carcinogenesis 23:687-696. Abstract Full text
D'Amours D and Jackson SP. (2002) The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 3:317-327. Abstract Full text
Durocher D and Jackson SP. (2002) The FHA domain. FEBS Letters 513:58-66. Abstract Full text
Jazayeri A and Jackson SP. (2002) Screening the yeast genome for new DNA-repair genes. Genome Biology 3:R1009.1-R1009.5. Abstract Full text
Magill CP, Jackson SP and Bell SD. (2001) Identification of a conserved archaeal RNA polymerase subunit contacted by the basal transcription factor TFB. J. Biol. Chem. 276:46693-46696. Abstract Full text
Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell TL and Pellegrini L. (2001) Crystal structure of an Xrcc4-DNA ligase IV complex. Nat. Struct. Biol. 8:1015-1020. Abstract Full text
Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, Jackson S and Wang ZQ. (2001) Disruption of Trapp causes early embryonic lethality and defects in cell cycle progression. Nat. Genet. 206:206-211. Abstract Full text
D'Amours D and Jackson SP. (2001) The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev. 15:2238-2249. Abstract Full text
d'Adda di Fagagna F, Hande MP, Tong W-M, Roth D, Lansdorp PM, Wang ZQ and Jackson SP. (2001) Effects of non-homologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr. Biol. 11:1192-1196. Abstract Full text
Freire R, d'Adda di Fagagna F, Wu L, Pedrazzie G, Stagljar I, Hickson ID and Jackson SP. (2001) Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase III alpha. Nucleic Acids Res. 29:3172-3180. Abstract Full text
Doherty AJ, Jackson SP and Weller GR. (2001) Identification of bacterial homologues of the Ku DNA repair proteins. FEBS Lett. 500:186-188. Full text
Eichhorn K and Jackson SP. (2001) A role for TAF3B2 in the repression of human RNA polymerase III transcription in non-proliferating cells. J. Biol. Chem. 276:21158-21165. Abstract Full text
Korkhin Y, Littlefield O, Nelson PJ, Bell SD and Sigler PB. (2001) Preparation of the components of the archeal transcription preinitiation complex. Methods Enzymol. 334:227-239. Full text
Bell SD, Brinkman AR, van der Oost J and Jackson SP. (2001) The archael TFIIEa homologue facilitates transcription initiation by enhancing TATA-box recognition. EMBO Reports 2:133-138. Abstract Full text
Teo S-H and Jackson SP. (2001) Telomerase subunits overexpression suppresses telomere-specific checkpoint activation in yku80 mutant. EMBO Reports 2:197-202. Abstract Full text
Khanna K, Lavin M, Jackson S and Mulhern T. (2001) ATM, a central controller of cellular responses to DNA damage. Cell Death Differ. 8:1052-1065. Abstract Full text
Jackson SP. (2001) DNA damage signalling and apoptosis. Biochem. Soc. Trans 29:655-661. Abstract Full text
Doherty AJ and Jackson SP. (2001) How Ku makes ends meet. Curr. Biol. 11:R920-R924. Abstract Full text
Bell SD, Magill CP and Jackson SP. (2001) Basal and regulated transcription in Archaea. Biochem. Soc. Trans 29:292-395. Abstract Full text
Khanna KK and Jackson SP. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27:247-254. Abstract Full text
Bell SD and Jackson SP. (2001) Mechanism and regulation of trancription in Archaea. Curr. Opin. Microbiol. 4:208-213. Abstract Full text
Durocher D and Jackson SP. (2001) DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13:225-231. Abstract Full text
Downs JA, Lowndes NF and Jackson SP. (2000) A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 408:1001-1004. Abstract Full text
Wilson CR, Davidson SE, Margison GP, Jackson SP, Hendry JH and West CML. (2000). Expression of Ku70 correlates with survival in carcinoma of the cervix. British Journal of Cancer 83:1702-1706. Abstract Full text
Rouse J and Jackson SP. (2000) LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J. 19:5801-5812. Abstract Full text
Durocher D, Taylor IA, Sarbassova D, Haire L H, Westcott SL, Jackson SP, Smerdon SJ and Yaffe MB. (2000) The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phosphodependent signaling mechanisms. Mol. Cell. 6:1169-1182. Abstract Full text
Bell SD and Jackson SP. (2000) Mechanism of autoregulation by an archaeal transcriptional repressor. J. Biol. Chem. 275:31624-31629. Abstract Full text
Errami A, Overkamp WJ, He DM, Friedl AA, Gell DA, Eckardt-Schupp F, Jackson SP, Hendrickson EA, Lohman PH and Zdzienicka MZ. (2000) A new X-ray sensitive CHO cell mutant of ionizing radiation group 7, XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination. Mutat. Res. 461:59-69. Abstract Full text
Bell SD and Jackson SP. (2000) The role of transcription factor B in transcription initiation and promoter clearance in the Archaeon Sulfolobus acidocaldarius. J. Biol. Chem. 275:12934-12940. Abstract Full text
Moens PB, Freire R, Tarsounas M, Spyropoulos B and Jackson SP. (2000) Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom's syndrome, suggest a role in recombination during meiotic prophase. J. Cell Sci. 113, 663-672. Abstract Full text
Teo S-H and Jackson SP. (2000) Lif1p targets the DNA ligase, Lig4p, to sites of DNA double-strand breaks. Curr. Biol. 10:165-168. Abstract Full text
Carlomagno F, Burnet NG, Turesson I, Nyman J, Peacock JH, Dunning AM, Ponder BAJ and Jackson SP. (2000) Comparison of DNA repair protein expression and activities between human fibroblast cell lines with different radiosensitivities. Intl. J. Cancer 85:845-849. Abstract Full text
Bell SD and Jackson SP. (2000) Charting a course through the RNA polymerase. Nat. Struct. Biol. 7, 703-705. Abstract Full text
Durocher D, Smerdon SJ, Yaffe MB and Jackson SP. (2000)The FHA domain in DNA repair and checkpoint signaling. Cold Spring Harbor Symposia on Quantitative Biology 65:423-431. No abstract available.
McAinsh AD, Bell SD and Jackson SP. (2000) Sir2: a key player in silencing, ageing and metabolism. The ELSO Gazette 1 Full text
Bell SD, Cairns SS, Robson RL and Jackson SP. (1999) Transcriptional regulation of an archaeal operon in vivo and in vitro. Mol. Cell 4, 971-982. Abstract Full text
Bell SD, Kosa PL, Sigler PB and Jackson SP. (1999) Orientation of the transcription preinitiation complex in Archaea. Proc. Natl Acad. Sci. USA 96, 13662-13667. Abstract Full text
Moens PB, Tarsounas M, Morita T, Habu T, Rottinghaus ST, Freire R, Jackson SP, Barlow C and Wynshaw-Boris A. (1999) The association of ATR protein with mouse meiotic chromosome cores. Chromosoma 108, 95-102. Abstract Full text
Gell D and Jackson SP. (1999). Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res. 27, 3493-3502. Abstract Full text
McAinsh AD, Scott-Drew S, Murray JAH and Jackson SP. (1999) DNA damage triggers loss of telomeric silencing and the Mec1p-dependent relocation of Sir3p. Curr. Biol. 9, 963-966. Abstract Full text
Durocher D, Henckel J, Fersht AR and Jackson SP. (1999). The FHA domain is a phosphopeptide recognition motif. Mol. Cell 4, 387-394. Abstract Full text
d'Adda di Fagagna F, Hande MP, Tong W-M, Lansdorp PM, Wang Z-Q and Jackson SP. (1999) Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat. Genet. 23, 76-80. Abstract Full text
Smith GCM, Cary RB, Lakin ND, Hann BC, Teo S-H, Chen DJ and Jackson SP. (1999) Purification and DNA-binding properties of the ataxia-telangiectasia gene product ATM. Proc. Natl. Acad. Sci. USA 96, 11134-11139. Abstract Full text
Smith GCM, d'Adda di Fagagna F, Lakin ND and Jackson SP. (1999) Cleavage and inactivation of ATM during apoptosis. Mol. Cell. Biol. 19, 6076-6084. Abstract Full text
Lakin ND, Hann BC and Jackson SP. (1999) The ataxia telangiectasia-related protein, ATR, mediates DNA-dependent phosphorylation of p53. Oncogene 18, 3989-3995. Abstract Full text
Downs J and Jackson SP. (1999) Involvement of DNA end-binding protein Ku in Ty element retrotransposition. Mol. Cell. Biol. 19, 6260-6268. Abstract Full text
*Riballo E, *Critchlow SE, Teo S-H, Doherty AJ, Priestley A, Broughton B, Kysela B, Beamish H, Plowman N, Artlett CF, Lehmann AR, Jackson SP and Jeggo PA. (1999) Identification of a deficit in DNA ligase IV in a radiosensitive leukaemia patient. Curr. Biol. 9, 699-702. *These authors contributed equally to this work Abstract Full text
Plumb MA, Smith GCM, Cunniffe SMT, Jackson SP and O'Neill P. (1999) DNA-PK activation by ionising radiation-induced DNA single-strand breaks. Intl. J. Rad. Biol. 75, 553-561. Abstract
Izzard RA, Jackson SP and Smith GCM. (1999) Competitive and non-competitive inhibition of the DNA-dependent protein kinase. Cancer Res. 59, 2581-2586. Abstract Full text
Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE and Jeggo PA. (1999) The C Terminus of Ku80 activates the DNA-Dependent protein kinase Mol. Cell. Biol. 19, 3267-3277. Abstract Full text
Smith GCM and Jackson SP. (1999) The DNA-dependent protein kinase. Genes Dev. 13, 916-934. No abstract available Full text
Jackson SP. (1999) Colworth medal lecture. Detection, repair and signalling of DNA double-strand breaks. Biochem. Soc. Trans. 27, 1-13. No abstract available
Lakin ND and Jackson SP. (1999) Regulation of p53 in response to DNA damage. Oncogene 18, 7644-7655. Abstract Full text
Featherstone C and Jackson SP. (1999) DNA double-strand break repair. Curr. Biol. 9, R759-R761. Full text
Featherstone C and Jackson SP. (1999) Ku, a DNA repair protein with multiple cellular functions? Mut. Res. DNA Repair 434, 3-15. Abstract Full text
Featherstone C and Jackson SP. (1999) DNA-dependent protein kinase gets a break: its role in repairing DNA and maintaining genomic integrity. Br. J. Cancer 80 (Supplement 1), 14-19.
Smith GCM, Divecha N, Lakin ND and Jackson SP. (1999) DNA-dependent protein kinase and related enzymes. Biochem. Soc. Symp. 64, 91-104. Abstract
Bell SD, Jaxel C, Nadal M, Kosa PF and Jackson SP. (1998) Temperature, template topology, and factor requirements of archaeal transcription. Proc. Natl Acad. Sci. USA 95, 15218-15222. Abstract Full text
Barlow C, Liyanage M, Moens PB, Tarsounas M, Nagashima K, Brown K, Rottinghaus S, Jackson SP, Tagle D, Ried T and Wynshaw-Boris A. (1998) Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I. Development 125, 4007-4017. Abstract Full text
Errami A, He DM, Friedl AA, Overkamp WJI, Morolli B, Hendrickson EA, EckardtSchupp F, Oshimura M, Lohman P HM and Jackson SP. (1998) XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation. Nucleic Acids Res. 26, 3146-3153. Abstract Full text
Errami A, Finnie NJ, Morolli B, Jackson SP, Lohmann PHM and Zdzienicka MZ. (1998) Molecular and biochemical characterization of new X-ray-sensitive hamster cell mutants defective in Ku80. Nucleic Acids Res. 26, 4332-4338. Abstract Full text
Escarceller M, Buchwald M, Singleton BK, Jeggo PA, Jackson SP, Moustacchi E and Papadopoulo D. (1998) Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end joining. J. Mol. Biol. 279, 375-385. Abstract Full text
Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Arzayus MIT, Priestley A, Jackson SP, Rothstein AM, Jeggo PA and Herrera VLM. (1998) Targeted disruption of the catalytic subunit of the DNA PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity 9, 355-366. Abstract Full text
Freire R, Murguia JR, Tarsounas M, Lowndes N, Moens PB and Jackson SP. (1998) Human and mouse homologues of S. pombe rad1+ and S. cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Genes Dev. 12, 2560-2573. Abstract Full text
Yavuzer U, Smith GCM, Bliss T, Werner D and Jackson SP. (1998) DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes Dev. 12, 2188-2199. Abstract Full text
Boulton SJ, and Jackson SP. (1998) Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17, 1819-1828. Abstract Full text
Qureshi SA and Jackson SP. (1998) Sequence-specific DNA binding by the Sulfolobus shibatae TFIIB homologue, TFB, and its effects on promoter strength. Mol. Cell 1, 389-400. Abstract Full text
Priestley A, Gell D, Singelton B, Beamish H, Amatucci A, Muhlmann-Diaz M, Smith GCM, Blunt T, Schwalk L, Jessberger R, Bedford J, Jackson SP, Jeggo PA and Taccioli G. (1998) Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Res. 26, 1965-1973. Abstract Full text
Trigon S, Serizawa H, Conaway JW, Conaway RC, Jackson SP and Morange M. (1998) Characterization of the residues phosphorylated in vitro by different C-terminal domain kinases. J. Biol. Chem. 273, 6769-6775. Abstract Full text
Bell SD and Jackson SP. (1998) Transcription in Archaea. Cold Spring Harbor Symp. Quant. Biol. LXIII, 41-51. No abstract available
Critchlow SE and Jackson SP. (1998) DNA end joining: from yeast to man. Trends Biochem. Sci. 23, 394-398. Abstract Full text
Featherstone C and Jackson SP. (1998) DNA repair: The Nijmegen breakage syndrome protein. Curr. Biol. 8, R622-R625. Abstract Full text
Bell SD and Jackson SP. (1998) Transcription and translation in Archaea: a mosaic of eukaryal and bacterial features. Trends Microbiol. 6, 222-228. Abstract Full text
Critchlow SE, Bowater RP and Jackson SP. (1997). Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 7, 588-598. Abstract Full text
Teo S-H and Jackson SP. (1997) Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. EMBO J. 16, 4788-4795. Abstract Full text
Qureshi SA, Bell SD and Jackson SP. (1997) Factor requirements for transcription in the archaeon Sulfolobus shibatae. EMBO J. 16, 2927-2936. Abstract Full text
Morrison C, Stingl L, Smith GCM, Jackson SP, Wagner EF and Wang Z-Q. (1997) Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumourigenesis. Nat. Genet. 17, 479-482. Abstract Full text
Larminie CGC, Cairns CA, Mital R, Martin K, Kouzarides T, Jackson SP and White RJ. (1997) Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein. EMBO J. 16, 2061-2071. Abstract Full text
Singleton BK, Priestley A, Steingrimsdottir H, Gell D, Blunt T, Jackson SP, Lehman AR and Jeggo PA. (1997). Molecular and biochemical characterisation of xrs mutants defective in Ku80. Mol. Cell. Biol. 17, 1264-1273. Abstract Full text
Jackson SP. (1997) Silencing and DNA repair connect. Nature 388, 829-830. Full text
Jackson SP. (1997) DNA-dependent protein kinase. Intl J. Biochem. Cell Biol. 29, 935-938. Abstract Full text
Elgin SC, Jackson SP. (1997) Chromosomes and expression mechanisms. Curr Opin Genet Dev. 7(2), 149-51. Editorial overview
Lakin ND, Weber P, Stankovic T, Rottinghaus ST, Taylor AM and Jackson SP. (1996) Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. Oncogene 13, 2707-2716. Abstract
Boulton SJ and Jackson SP. (1996) Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double-strand break rejoining and in telomeric maintenance. Nucl. Acids Res. 24, 4639-4638. Abstract Full text
Boulton SJ and Jackson SP. (1996). Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15, 5093-5103. Abstract Full text
Baumann P and Jackson SP. (1996) An archaebacterial homologue of the essential eubacterial cell division protein FtsZ. Proc. Natl Acad. Sci. USA 93, 6726-6730. Abstract Full text
Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA and Jackson SP. (1996) DNA-dependent protein kinase defects are linked to deficiencies in DNA repair and V(D)J recombination. Phil. Trans. Roy. Soc. 351, 173-179. Abstract
Blunt T, Gell D, Fox M, Taccioli GE, Lehmann AR, Jackson SP and Jeggo PA. (1996) Identification of a nonsense mutation in the carboxy-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc. Natl Acad. Sci. USA 93, 10285-10290. Abstract Full text
de Decker BS, O'Brien R, Fleming PJ, Geiger JH, Jackson SP and Sigler PB. (1996) The crystal structure of a hyperthermophilic archaeal TATA-box-binding protein. J. Mol. Biol. 264, 1072-1084. Abstract Full text
White RJ, Trouche D, Martin K, Jackson SP and Kouzarides T. (1996) Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature 382, 88-90. Abstract Full text
Jongmans W, Artuso M, Vuillaume M, Brésil H, Jackson SP and Hall J. (1996) The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation. Oncogene 13, 1133-1138. Abstract
Williams RD, Lee B, Jackson SP and Proudfoot NJ. (1996) Activation domains of transcription factors mediate replication dependent transcription from a minimal HIV-1 promoter. Nucl. Acids Res. 24, 549-557. Abstract Full text
Le Romancer M, Cosulich SC, Jackson SP and Clarke PR. (1996) Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts. J. Cell. Sci. 109, 3121-3127. Abstract Full text
Song Q, Burrows SR, Smith G, Lees-Miller SP, Kumar S, Chan DW, Trapani JA, Alnemri E, Litwack G, Lu H, Moss DJ, Jackson SP and Lavin MF. (1996) ICE-like protease cleaves DNA-dependent protein kinase in cytotoxic T-cell killing. J. Exp. Med. 184, 619-626. Abstract Full text
Song Q, Lees-Miller SP, Kumar S, Zhang N, Smith GCM, Jackson SP, Alnermri ES, Litwack G and Lavin MF. (1996) DNA-dependent protein kinase catalytic subunit: a target for the ICE-like protease CPP32 in apoptosis. EMBO J. 15, 3238-3246. Abstract Full text
Nicolas N, Finnie NJ, Cavazzana-Calvo M, Papadopoulo D, Le Deist F, Fischer A, Jackson SP and de Villartay J-P. (1996). Lack of detectable defect in DNA-double strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts. Eur. J. Immunol. 26, 1118-1122. Abstract
Grawunder U, Finnie N, Jackson SP, Riwar B and Jessberger R. (1996) Expression of DNA-dependent protein kinase holoenzyme upon induction of B- lymphocyte differentiation and V(D)J rearrangement. Eur. J. Biochem. 241, 931-940. Abstract
Jackson SP. (1996) The recognition of DNA damage. Curr. Opin. Genet. Dev. 6, 19-25. Abstract
Jackson SP. (1996). DNA damage detection by DNA-dependent protein kinase and related enzymes. Cancer Surveys 28, 261-279. Abstract
Jeggo PA, Jackson SP and Taccioli GE. (1996) Identification of the catalytic subunit of DNA dependent protein kinase as the product of the SCID mouse gene. Curr. Topics. Microbiol. Immunol. 217, 79-89. No abstract available
White RJ, Gottlieb TM, Downes CS and Jackson SP. (1995) Cell cycle regulation of RNA polymeraseIII transcription. Mol. Cell. Biol. 15, 6653-6662. Abstract Full text
Hartley K, Gell D, Smith GCM, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW and Jackson SP. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinaseand the ataxia telangiectasia gene product. Cell 82, 849-856. Abstract Full text
Blunt T*, Finnie NJ*, Taccioli GE, Smith GCM, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt F, Jeggo PA and Jackson SP. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823. *These authors contributed equally to this work Abstract Full text
Qureshi SA, Baumann P, Rowlands T, Khoo B and Jackson SP. (1995) Cloning and functional analysis of the TATA-binding protein from Sulfolobus shibatae. Nucl. Acids Res. 23, 1775-1781. Abstract Full text
Qureshi SA, Khoo B, Baumann P and Jackson SP. (1995) Molecular cloning and functional analysis of the TFIIB homologue from the Archaeon Sulfolobus shibatae. Proc. Natl Acad. Sci. USA 92, 6077-6081. Abstract Full text
White RJ, Gottlieb TM, Downes CS and Jackson SP. (1995) Mitotic regulation of a TBP-containing complex. Mol. Cell. Biol. 15, 1983-1992. Abstract Full text
Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA and Jackson SP. (1995) DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl Acad. Sci. USA 92, 320-324. Abstract Full text
Blunt T, Taccioli G, Priestley A, Hafezparast M, McMillan T, Liu J, Cole C, White J, Alt F, Jackson SP, Schurr E, Lehmann A and Jeggo P. (1995) A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion. Genomics 30, 320-328. Abstract Full text
Miller RD, Hogg J, Ozaki JH, Gell D, Jackson SP and Riblet R. (1995) Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc. Natl Acad. Sci. USA 92, 10792-10795. Abstract Full text
Sipley JD, Mennenger JC, Hartley K, Ward DC, Jackson SP and Anderson CW. (1995). The gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. Proc. Natl Acad. Sci. USA 92, 7515-7519. Abstract Full text
Jackson SP. (1995) Ataxia-telangiectasia at the cross-roads. Curr. Biol. 5, 1210-1212. Abstract Full text
Jackson SP and Jeggo PA. (1995) DNA double-strand break repair, V(D)J recombination, and the involvement of DNA-PK. Trends Biochem. Sci. 20, 412-415. Abstract Full text
Jeggo PA, Taccioli GE and Jackson SP. (1995) Menage-a-trois: double-strand break repair, V(D)J recombination and DNA-PK. BioEssays 17, 949-957. Abstract
Baumann PB, Qureshi, SA and Jackson SP. (1995) Transcription - new insights from studies on Archaea. Trends Genet. 11, 279-283. Abstract Full text
Khoo BC-E, Brophy B and Jackson SP. (1994) Conserved functional domains of the RNA polymerase III general transcription factor BRF. Genes Dev. 8, 2879-2890. Abstract Full text
Kuhn A, Gottlieb TM, Jackson SP and Grummt I. (1995) DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. Genes Dev. 9, 193-203. Abstract Full text
White RJ, Khoo BC-E, Inostroza JA, Reinberg D and Jackson SP. (1994) The TBP-binding repressor Dr1 differentially regulates RNA polymerases I, II, and III. Science 266, 448-450. Abstract Full text
Rowlands T, Baumann P and Jackson SP. (1994) The TATA-binding protein: a general transcription factor in eukaryotes and archaebacteria. Science 264, 1326-1329. Abstract Full text
Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Alt FW, Lehmann AR, Jackson SP and Jeggo PA. (1994) Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination Science 265, 1442-1445. Abstract Full text
Anderson CW, Connelley MA, Zhang H, Sipley JD, Lees-Miller SP, Sakaguchi K, Ullrich SJ, Jackson SP and Appella E. (1994) The human DNA-activated protein kinase, DNA-PK, is activated by DNA breaks and phosphorylates nuclear DNA-binding substrates on serines and threonines following glutamine. J. Prot. Chem. 13, 500-501.
Gottlieb TM and Jackson SP. (1994) Protein kinases and DNA damage. Trends Biochem. Sci. 19, 500-503. Abstract
Gottlieb TM and Jackson SP. (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142. Abstract Full text
Bannister AJ, Gottlieb TM, Kouzarides T and Jackson SP. (1993) c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucl. Acids Res. 21, 1289-1295. Abstract Full text
Finnie N, Gottlieb T, Hartley K and Jackson SP. (1993) Transcription factor phosphorylation by the DNA-dependent protein kinase. Biochemical Society Transactions 21, 930-935. No abstract available
Jackson S, Gottlieb T and Hartley K. (1993) Phosphorylation of transcription factor SP1 by the DNA-dependent protein kinase. Advances in Second Messenger and Phosphoprotein Research 28, 279-286. No abstract available
White RJ and Jackson SP. (1992) Mechanism of TATA-binding protein recruitment to a TATA-less ClassIII promoter. Cell 71, 1041-1053. Abstract Full text
White RJ, Rigby PWJ and Jackson SP. (1992) The TATA-binding protein is a general transcription factor for RNA polymerase III. J. Cell Sci Suppl. 16, 1-7. Abstract
White RJ, Jackson SP and Rigby PWJ. (1992) A role for the TATA-binding protein component of the TFIID complex as a general RNA polymerase III transcription factor. Proc. Natl Acad. Sci. USA 89, 1949-1953. Abstract Full text
White RJ and Jackson SP. (1992) The TATA-binding protein: a central role in transcription by RNA polymerases I, II and III. Trends Genet. 8, 284-288. Abstract
Jackson SP. (1992) Regulating transcription factor activity by phosphorylation. Trends Cell Biol. 2, 104-108. Abstract
Jackson SP, MacDonald JJ, Lees-Miller S and Tjian R. (1990) GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63, 155-165. Abstract Full text