• Research Focus:
The nucleosome is decorated with many different types of histone modification. These can potentially effect any biological process. Our lab is involved in identifying and characterising the role of these modifications in the process of transcription. Our interest is fueled by the fact that many of the pathways that lead to histone modification are deregulated in cancer. We are keen to understand how misregulation generates uncontrolled cell growth. For more information see the About the Lab section.

• Selected Recent Publications:

Xhemalce B, Kouzarides T. (2010)
A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.
Genes Dev. 24(7), 647-652.

Dawson MA, Bannister AJ, Göttgens B, Foster SD, Bartke T, Green AR, Kouzarides T. (2009)
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
Nature. 461(7265), 819-822.

Santos-Rosa H, Kirmizis A, Nelson C, Bartke T, Saksouk N, Cote J, Kouzarides T. (2009)
Histone H3 tail clipping regulates gene expression.
Nat Struct Mol Biol. 16(1), 17-22.

Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Vermeulen M, Mann M, Bahler J, Green RD, Kouzarides T. (2007)
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation.
Nature. 449(7164), 928-932. Additional data.

Kouzarides T. (2007)
Chromatin modifications and their function.
Cell. 128(4), 693-705.

Nelson CJ, Santos-Rosa H, Kouzarides T. (2006)
Proline isomerization of histone h3 regulates lysine methylation and gene expression.
Cell. 126(5), 905-916.

See Also: Entire Publication List