Welcome to the home page of the Livesey lab at the Gurdon Institute and Department of Biochemistry, University of Cambridge.
Our group investigates the development, evolution and disease of the cerebral cortex. We are using neurons derived from human pluripotent stem cells to explore the mechanisms at work in neuro-development and degeneration.
If you would like to join us to take part in this research in any position, please contact Rick Livesey.
The Livesey lab is hiring. We are currently looking for one post-doctoral researcher and one stem cell research assistant. More details available on the Gurdon Institute vacancies page.
Welcome to our new lab member Phillip, and to our three students joining us for the summer.
We are frequently asked about our protocols for making cortex-in-a-dish. The lab published an article describing a method for deriving cortical neurons from human iPSCs. Since there has been a great deal of interest in the technique, we have produced a protocol paper describing the technique more thoroughly.
We said goodbye to three wonderful lab members recently: Therese Andersson has finished her post-doc with us and is setting up her own group in Stockholm; Selina Wray leaves after working with us for six months and takes her neurons back to UCL; and Roberta Cagnetta returns to Italy to complete her studies.
AD is the most common cause of dementia worldwide, and on the increase in an aging population.
Because of the difficulty in studying Alzheimer’s progression in vivo, and the limitations of animal models, we are using our system to discover more about how the disease develops, and how it could be treated.
Human iPS cells (
induced Pluripotent stem
cells) are adult cells - usually from the skin
- which have been 'reprogrammed' to an
embryonic state. These have the potential to be turned into
any type of cell from the body, and we
differentiate these into cortical neurons. The reseachers
behind the development of iPS technology, Prof
Sir John Gurdon, and Prof Shinya Yamanaka were
awarded the 2012 Nobel Prize for their work.