MOLECULAR BASIS OF MESODERM FORMATION
Jim Smith and colleagues

Jim's Publications since 1998

Jones, C.M. and Smith, J.C. (1998).
Establishment of a BMP-4 morphogen gradient by long-range inhibition.
Developmental Biology 194, 12-17.

Casey, E., O'Reilly, M-A.J., Conlon, F.L. and Smith, J.C. (1998).
The T-box transcription factor Brachyury regulates expression of eFGF through binding to a non-palindromic response element.
Development 125, 3887-3894.

Tada, M., Casey, E. Fairclough, L. and Smith, J. C. (1998).
Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm.
Development 125, 3997-4006.

Conlon, F. L. and Smith, J. C. (1999).
Interference with Brachyury function inhibits convergent extension, causes apoptosis, and reveals separate requirements in the FGF and activin signalling pathways.
Dev. Biol. 213, 85-100.

Wuytens, G., Verschueren, K., de Winter, J. P., Gajendran, N., Beek, L., Devos, K., Bosman, F., de Waele, P., Maria Andries, M., van den Eijnden-van Raaij, A. J. M., Smith, J. C. and Huylebroeck, D. (1999).
Identification of two amino acids in activin A that are important for biological activity and binding to the activin type II receptors.
J. Biol. Chem. 274, 9821-9827.

Verschueren, K., Remacle, J.E., Kraft, H., Collart, C., Baker, B.S., Tylzanowski, P., Nelles, L., Su, M-T., Bodmer, R., Smith, J.C. and Huylebroeck, D. (1999).
SIP1, a novel zinc finger/homeodomain protein, interacts with Smad proteins and binds to 5'-CACCT sequences in several target genes.
J. Biol. Chem. 274, 20489-20498.

Armes, N.A., Neal, K. and Smith, J.C. (1999).
A short loop on the ALK-2 and ALK-4 activin receptors regulates signalling specificity but cannot account for all their effects on early Xenopus development.
J. Biol. Chem. 274, 7929-7935.

Rodaway, A., Takeda, H., Koshida, S., Broadbent, J., Price, B., Smith, J.C., Patient, R. and Holder, N. (1999).
Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF.
Development 126, 3067-3078.

Latinkic, B.V. and Smith, J.C. (1999).
Goosecoid and Mix.1 repress Brachyury expression and are required for head formation in Xenopus.
Development 126, 1769-1779.

Smith, J. (1999).
T-box genes: what they do and how they do it.
Trends in Genetics 15, 154-158.

Jones, C.M. and Smith, J.C. (1999).
An overview of Xenopus development.
Molecular Embryology: Methods and Protocols (eds P.T. Sharpe and I. Mason). Humana Press, Totowa, New Jersey. pp 331-340.

Jones, C.M. and Smith, J.C. (1999).
Mesoderm induction assays.
Molecular Embryology: Methods and Protocols (eds P.T. Sharpe and I. Mason). Humana Press, Totowa, New Jersey. pp 341-350.

Jones, C.M. and Smith, J.C. (1999).
Wholemount in situ hybridization to Xenopus embryos.
Molecular Embryology: Methods and Protocols (eds P.T. Sharpe and I. Mason). Humana Press, Totowa, New Jersey. pp 635-640.

Jones, C.M., Thomas, P.Q., Smith, J.C. and Beddington, R.S.P. (1999).
An anterior signalling centre in Xenopus revealed by the homeobox gene Xhex.
Current Biology 9, 946-954.

Casey, E.S., Tada, M., Fairclough, L., Wylie, C.C., Heasman, J. and Smith, J.C. (1999).
Bix4 is activated directly by VegT and mediates endoderm formation in Xenopus development.
Development 126, 4193-4200.

Remacle, J.E., Kraft, H., Lerchner, W., Wuytens, G., Collart, C., Verschueren, K., Smith, J.C. and Huylebroeck, D. (1999).
New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites.
EMBO J. 18, 5073-5084.

Trindade, M., Tada, M. and Smith, J.C. (1999).
DNA-binding specificity and embryological function of Xom (Xvent-2).
Dev. Biol. 216, 442-456.

Papin, C. and Smith, J.C. (2000).
Gradual refinement of activin-induced thresholds requires protein synthesis.
Dev. Biol. 217, 166-172.

Saka, Y., Tada, M. and Smith, J.C. (2000).
A screen for targets of Xbra.
Mechanisms of Development 93, 27-39.

Tada, M. and Smith, J.C. (2000).
Xwnt11, a target of Xenopus Brachyury, regulates gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.
Development 127, 2227-2238.

Brickman, J.M., Jones, C.M., Clements, M., Smith, J.C. and Beddington, R.S.P. (2000).
Hex is a transcriptional repressor that contributes to anterior identity and suppresses the Spemann organizer function.
Development 127, 2303-2315.

Smith, J.C. (2000).
Not a total waste of time. An interview with John Gurdon.
Int. J. Dev. Biol. 44, 93-99.

Smith, J.C. (2000).
From engineering to positional information to public understanding. An interview with Lewis Wolpert.
Int. J. Dev. Biol. 44, 85-91.

Heisenberg, C-P., Tada, M., Saude, L., Concha, M.L., Rausch, G-J., Geisler, R.E., Stemple, D., Smith, J.C. and Wilson, S. (2000).
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation.
Nature 405, 76-81.

Smith, J.C., Conlon, F.L., Saka, Y. and Tada, M. (2000).
Xwnt11 and the control of gastrulation in Xenopus.
Phil Trans. Roy. Soc. B. 355, 923-930.

Lerchner, W., Latinkic, B.V., Remacles, J., Huylebroeck, D. and Smith, J.C. (2000).
Region-specific activation of the Xenopus Brachyury promoter involves active repression in ectoderm and endoderm: a study using transgenic frog.
Development 127, 2729-2739.

Van Grunsven, L.A., Papin, C., Avalosse, B., Opdecamp, K., Huylebroeck, D., Smith, J.C. and Bellefroid, E.J. (2000).
XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development.
Mechanisms of Development 94, 189-193.

Smith, J.C. (2001).
Making mesoderm: upstream and downstream of Xbra.
Int. J. Dev. Biol. 45, 219-224.

Saka, Y. and Smith, J.C. (2001).
Spatial and temporal patterns of cell division during early Xenopus embryogenesis.
Dev. Biol. 229, 307-318.

Rodriguez, T.A., Casey, E.S., Harland, R.M., Smith, J.C. and Beddington, R.S.P. (2001).
Distinct enhancer elements control Hex expression during gastrulation and early organogenesis.
Developmental Biology, 234, 304-316.

Tada, M. and Smith, J.C. (2001).
T-targets: clues to understanding the functions of T-box proteins.
Development, Growth and Differentiation 43, 1-11.

Conlon, F.L., Fairclough, L., Price, B.M.J., Casey, E.S. and Smith, J.C. (2001).
Determinants of T box protein specificity.
Development 128, 3749-3758.

Domingos, P.M., Itasaki, N., Jones, C.M., Mercurio, S., Sargent, M.G., Smith, J.C., Krumlauf, R. (2001).
The Wnt/beta-catenin pathway posteriorizes neural tissue in Xenopus by an indirect mechanism requiring FGF signalling
Developmental Biology, 239, 148-160.

Papin, C., van Grunsven, L.A., Verschueren, K., Huylebroeck, D., Smith, J.C. (2001). Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1.
Mech. Dev., 111, 37-46.

Wolpert, L., Beddington, R., Jessell, T., Lawrence, P., Meyerowitz, E. and Smith, J. (2002). Principles of Development 2nd Edition. Oxford University Press.

Smith, J. (2002). Growth factors as developmental signals. In Great Experiments
(http://www.ergito.com/servlet/Lookup?expt=smith)

White, R.J., Sun, BI., Sive, H.L. and Smith, J.C. (2002). Direct and indirect regulation of derriere, a Xenopus mesoderm-inducing factor, by VegT. Development 129, 4867-4876

Khokha, M.K., Chung, C., Bustamante, E.L., Gaw, L.W.K., Trott, K.A., Yeh, J., Lim, N., Lind, J.C.Y., Taverner, N., Amaya, E., Papalopolou, N., Smith, J.C., Zorn, A., Harland, R.M. and Grammer, T.C. (2002). Techniques and probes for the study of Xenopus tropicalis development. Dev. Dynamics 225, 499-510.

Smith, J.C. and White, R. (2003).
Patterning the Xenopus embryo.
In Patterning in Vertebrate Development (ed. Cheryll Tickle). Oxford University Press, pp 24-47.

Smith, J. (2003) Ch-ch-ch-ch-changes... Development 130, 1.

D'Souza, A., Lee, M., Taverner, N., Mason, J., Carruthers, S., Smith, J.C., Amaya, E., Papalopulu, N. and Zorn, A.M. (2003). Molecular components of the endoderm specification pathway in Xenopus tropicalis. Dev. Dyn. 226, 118-127.

Latinkic, B.V., Mercurio, S., Bennett, B., Hirst, EM.A., Xu, Q., Lau, L.F., Mohun, T.J. and Smith, J.C. (2003). Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling. Development, 130, 2429-2441.

Marcellini, S., Technau, U., Smith, J.C. and Lemaire, P. (2003). Evolution of Brachyury proteins: Identification of a novel regulatory domain conserved between bilateria. Dev. Biol.,260, 352-361.

Trindade, M., Messenger, N., Papin, C., Grimmer, D., Fairclough, L., Tada, M. and Smith, J.C. (2003). Regulation of apoptosis in the Xenopus embryo by Bix3. Development, 130, 4611-4622.

Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P.M., Smith, J.C. and Krumlauf, R. (2003). Wise, a context-dependent activator and inhibitor of Wnt signalling. Development 130, 4295-4305.

de Sousa Nunes, R., Rana, A., Kettleborough, R., Brickman, J., Clements, M., Forrest, A., Grimmond, S., Avner, P., Smith, J.C., Dunwoodie, S.L. and Beddington, R.S.P. (2003). Characterising embryonic gene expression using a non-redundant sequence-based selection method. Genome Research, 13, 2609-2630.

Smith, J. (2003). More changes. Development 130, 3075.

Smith, J.C. (2004). T-box genes and the regulation of gastrulation. In Gastrulation. Edited by Claudio Stern. Cold Spring Harbor Laboratory Press, pp 571-580.

Mercurio, S., Latinkic, B., Itasaki, N., Krumlauf, R. and Smith, J.C. (2004). Connective-tissue growth factor (CTGF) modulates cell signalling by Wnt family members. Development 131, 2137-2147.

Gilchrist, M., Zorn, A.M., Voigt, J., Smith, J.C., Papalopulu, N. and Amaya, E. (2004). Defining a large set of full length clones from a Xenopus tropicalis EST project. Dev. Bio. 271, 498-516

Srinivas, S., Tristan Rodriguez, T., Clements, M., Smith, J.C. and Beddington, R.S.P. (2004). Active cell migration drives the unilateral movements of the Anterior Visceral Endoderm. Development 131, 1157-1164

Piepenburg, O., Grimmer, D., Williams, P.H. and Smith, J.C. (2004). Activin redux: specification of mesodermal pattern in Xenopus by graded concentrations of endogenous activin B. Development 131, 4977-4986

Williams, P.H., Hagemann, A., Gonzalez-Gaitan, M. and Smith, J.C. (2004). Visualizing long-range movement of the morphogen Xnr2 in the Xenopus embryo. Current Biology, 14, 1916-1923

Saka, Y. and Smith, J.C. (2004). A Xenopus tribbles orthologue is required for the progression of mitosis and for development of the nervous system. Dev. Biol. 273, 210-225

Taverner, N.V., Smith, J.C. and Wardle, F.C. (2004). Identifying transcription factor targets. Genome Biology 5, 210

Wardle, F.C. and Smith, J.C. (2004). Heterogeneity of gene expression patterns in the early Xenopus embryo. Development 131, 4687-4696

Bromley, E., Knapp, D., Wardle, F.C., Sun, B.I., Collins-Racie, L., LaVallie, E., Smith, J.C. and Sive, H.L. (2004). Identification and characterisation of the Xenopus Neurotrophin Receptor Homolog genes fullback and fullback-like. Gene Expression Patterns 5, 135-140

Rana, A.A., Martinez Barbera, J.P., Rodriguez, T.A., Lynch, D., Hirst, E., Smith, J.C. and Beddington, R.S.P. (2004). Targeted deletion of hte novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser and the formation of th body axes. Development 131, 4999-5007

Smith, J.C. and Gurdon, J.B. (2004). Many ways to make a gradient. BioEssays 26, 705-706

Kiefer, J.C. [and Gibson-Brown, J. Grunwald, D. and Smith, J.C.] (2004). The Tbx-files: The truth is out there. Dev. Dyn. 231, 232-236

Chalmers, A.D., Goldstone, K., Smith, J.C., Gilchrist, M., Amaya, E. and Papalopulu, N. (2005). A Xenopus tropicalis oligonucleotide microarray works across species using RNA from Xenopus laevis. Mech. Dev. 122, 355-363

Brown, D.D., Shauna, N., Martz, S.N., Binder, O., Price, B.M.J., Smith, J.C. and Conlon, F.L. (2005). Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis. Development 132, 553-563

Smith, J. (2005). 'Beddington, Rosa Susan Penelope (1956-2001)', Oxford Dictionary of National Biography, online edition, Oxford University Press, Jan 2005 [http://www.oxforddnb.com/view/article/75857]

Smith, J.C. (2005) Xenopus genetics and genomics: Introduction. Mech. Dev. 122, 259-262

Taverner, N.V., Kofron, M., Shin, Y., Kabitschke, C., Gilchrist, M.J., Wylie, C., Cho, K.W.Y., Heasman, J. and Smith, J.C. (2005). Microarray-based identification of VegT targets in Xenopus. Mech. Dev. 122, 333-354

Birsoy, B., Berg, L.B., Williams, P.H., Smith, J.C., Wylie, C.C., Christin, J.L. and Heasman, J. (2005). XPACE4 is a localized proprotein convertase required for mesoderm induction and the cleavage of specific TGF-beta proteins in Xenopus development. Development 132, 591-602

Callery, E.M., Smith, J.C. and Thomsen, G.H. (2005). The ARID domain protein dril1 is necessary for TGFbeta signaling in Xenopus embryos. Dev. Biol. 278, 542-559

Messenger, N.J., Kabitschke, C., Andrews, R., Grimmer, D., Nunez Miguel, R., Blundell, T.L., Smith, J.C. and Wardle, F.C. (2005) Functional specificity of the T-domain protein Brachyury is conferred by its ability to interact with Smad1. Developmental Cell 8, 599-610

Srinivas, S., Rodriguez, T., Clevements, M., Smith, J.C. and Beddington, R. (2005). Induction and migration of the anterior visceral endoderm is regulated by the extra-embryonic ectoderm. Development 132, 2513-2520

Collart, C., Verschueren, K., Rana, A., Smith, J.C.* and Huylebroeck, D.* (2005). The novel Smad-interacting protein Smicl regulates Chordin expression in the Xenopus embryo. Development, in press.

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