This month's Oscars:

Best Result: Paula

Best Idea: Maryna and Richard

Best Lab Citizen: CY

Latest papers:

Skamagki et al., Cell Reports, Jan 2013

Asymmetric Localization of Cdx2 mRNA during the First Cell-Fate Decision in Early Mouse Development

Morris et al., Cell Reports, Oct 2012

Developmental Plasticity Is Bound by Pluripotency and the Fgf and Wnt Signaling Pathways.

Morris et al., Nature Communications, Feb 2012

Dynamics of anterior-posterior axis formation in the developing mouse embryo.

Ajduk et al., Nature Communications, Aug 2011

Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability.

Zernicka-Goetz, Nature Cell Biology, Feb 2010

Proclaiming fate in the early mouse embryo.

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OUR RESEARCH

Em Embryo

Cell polarity, cell position and gene expression in cell fate decisions in the early mouse embryo

We are investigating the cellular and molecular mechanisms underlying cell fate decisions in the early mouse embryo.

See Research for more details...

Recent News

  • Asymmetric Localization of Cdx2 mRNA during the First Cell Fate Decision in Early Mouse Development:
    A longstanding question in mouse development is whether divisions that set apart pluripotent and differentiating cells are asymmetric in cell-fate instructions. Cdx2 is a key factor in this first fate decision. We report in our latest paper in Cell Reports that localization and inheritance of Cdx2 transcripts become asymmetric as pluripotent and differentiating lineages segregate at the 8-16 cell stage transition. We show that asymmetric localization of Cdx2 transcripts requires cell polarization as well as intact microtubule and actin cytoskeletons, and that mislocalization of Cdx2 transcripts decreases the number of pluripotent cells, which significantly compromises developmental potential. ..see more at Cell Reports     Access the recommendation on F1000Prime

    • Early Mouse Development

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