Publications
Zernicka-Goetz M.
Proclaiming fate in the early mouse embryo.
Nat Cell Biol. 2011 Feb;13(2):112-4. Pubmed
Sharif B, Na J, Lykke-Hartmann K, McLaughlin SH, Laue E, Glover DM, Zernicka-Goetz M.
The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.
J Cell Sci. 2010 Dec 15;123(Pt 24):4292-300. Pubmed
Zernicka-Goetz M, Huang S.
Stochasticity versus determinism in development: a false dichotomy?
Nat Rev Genet. 2010 Nov;11(11):743-4. Pubmed
Parfitt DE, Zernicka-Goetz M.
Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo.
Mol Biol Cell. 2010 Aug 1;21(15):2649-60. Pubmed
Jedrusik A, Bruce AW, Tan MH, Leong DE, Skamagki M, Yao M, Zernicka-Goetz M.
Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo.
Dev Biol. 2010 Apr 27. Pubmed
Morris SA, Teo RT, Li H, Robson P, Glover DM, Zernicka-Goetz M.
Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.
Proc Natl Acad Sci U S A. 2010 Mar 22. Pubmed
Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford CF, Glover DM, Zernicka-Goetz M.
CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation.
Stem Cells. 2009 Nov;27(11):2637-45. Pubmed
Zernicka-Goetz M, Morris SA, Bruce AW.
Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo.
Nat Rev Genet. 2009 Jul;10(7):467-77. Pubmed
Meilhac SM, Adams RJ, Morris SA, Danckaert A, Le Garrec JF, Zernicka-Goetz M.
Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst.
Dev Biol. 2009 Jul 15;331(2):210-21. Epub 2009 May 5. Pubmed
Jedrusik A, Parfitt DE, Guo G, Skamagki M, Grabarek JB, Johnson MH, Robson P, Zernicka-Goetz M.
Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo.
Genes Dev. 2008 Oct 1;22(19):2692-706. Pubmed
Lykke-Andersen K, Gilchrist MJ, Grabarek JB, Das P, Miska E, Zernicka-Goetz M.
Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition.
Mol Biol Cell. 2008 Oct;19(10):4383-92. Pubmed
Soares ML, Torres-Padilla ME, Zernicka-Goetz M.
Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo.
Dev Growth Differ. 2008 Sep;50(7):615-21. Pubmed
Bischoff M, Parfitt DE, Zernicka-Goetz M.
Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions.
Development. 2008 Mar;135(5):953-62. Pubmed
Perea-Gomez A, Meilhac SM, Piotrowska-Nitsche K, Gray D, Collignon J, Zernicka-Goetz M.
Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder.
BMC Dev Biol. 2007 Aug 16;7:96. Pubmed
Torres-Padilla ME, Richardson L, Kolasinska P, Meilhac SM, Luetke-Eversloh MV, Zernicka-Goetz M.
The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.
Dev Biol. 2007 Sep 1;309(1):97-112. Pubmed
Frankenberg S, Smith L, Greenfield A, Zernicka-Goetz M.
Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.
BMC Dev Biol. 2007 Feb 15;7:8. Pubmed
Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M.
Histone arginine methylation regulates pluripotency in the early mouse embryo.
Nature. 2007 Jan 11;445(7124):214-8. Pubmed
Na J, Lykke-Andersen K, Torres Padilla ME, Zernicka-Goetz M.
Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.
Dev Biol. 2007 Feb 1;302(1):40-9. Pubmed
Torres-Padilla ME, Zernicka-Goetz M.
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote.
J Cell Biol. 2006 Jul 31;174(3):329-38. Pubmed
Zernicka-Goetz M.
The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice.
Curr Opin Genet Dev. 2006 Aug;16(4):406-12. Pubmed
Na J, Zernicka-Goetz M.
Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function.
Curr Biol. 2006 Jun 20;16(12):1249-54. Pubmed
Torres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T, Zernicka-Goetz M.
Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos.
Int J Dev Biol. 2006;50(5):455-61. Pubmed
Richardson L, Torres-Padilla ME, Zernicka-Goetz M.
Regionalised signalling within the extraembryonic ectoderm regulates anterior visceral endoderm positioning in the mouse embryo.
Mech Dev. 2006 Apr;123(4):288-96. Pubmed
Soares ML, Haraguchi S, Torres-Padilla ME, Kalmar T, Carpenter L, Bell G, Morrison A, Ring CJ, Clarke NJ, Glover DM, Zernicka-Goetz M.
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.
BMC Dev Biol. 2005 5:28. Pubmed
Zernicka-Goetz M.
Developmental cell biology: cleavage pattern and emerging asymmetry of the mouse embryo.
Nat Rev Mol Cell Biol. 2005 6:919-28. Pubmed
Moore CA, Zernicka-Goetz M.
PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles.
Reproduction. 2005 130:311-20. Pubmed
Piotrowska-Nitsche K, Zernicka-Goetz M
Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo.
Mech Dev. 2005 122:487-500. Pubmed
Plusa B, Hadjantonakis AK, Gray D, Piotrowska-Nitsche K, Jedrusik A, Papaioannou VE, Glover DM, Zernicka-Goetz M.
The first cleavage of the mouse zygote predicts the blastocyst axis.
Nature. 2005 434:391-5. Pubmed
Plusa B, Frankenberg S, Chalmers A, Hadjantonakis AK, Moore CA, Papalopulu N, Papaioannou VE, Glover DM, Zernicka-Goetz M.
Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo.
J Cell Sci. 2005 118:505-15. Pubmed
Piotrowska-Nitsche K, Perea-Gomez A, Haraguchi S, Zernicka-Goetz M.
Four-cell stage mouse blastomeres have different developmental properties.
Development. 2005 Feb;132(3):479-91. Pubmed
Carpenter L, Zernicka-Goetz M.
Directing pluripotent cell differentiation using "diced RNA" in transient transfection.
Genesis. 2004 Nov;40(3):157-63. Pubmed
Zernicka-Goetz M.
First cell fate decisions and spatial patterning in the early mouse embryo.
Semin Cell Dev Biol. 2004 5: 563-72. Pubmed
Mesnard D, Filipe M, Belo JA, Zernicka-Goetz M.
The anterior-posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation.
Current Biol. 2004 14:184-96. Pubmed
Gray, D., Plusa, B., Piotrowska, K., Glover, D. M., Tom, B. and Zernicka-Goetz, M.
First cleavage of the mouse embryo responds to egg geometry that reflects the position of sperm entry.
Current Biol. 2004 9:397-405. Pubmed
Wang, Q.T., Piotrowska, K., Ciemerych, M.A., Milenkovic, L., Scott, M.P., Davis, R.W. and Zernicka-Goetz, M.
A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo.
Developmental Cell 2004 Jan: 6, 133-144. Pubmed
Grabarek JB, Zernicka-Goetz M.
RNA interference in mammalian systems--a practical approach.
Adv Exp Med Biol. 2003;544:205-16. Pubmed
Plusa B., Grabarek J.B., Piotrowska K., Glover D.M, Zernicka-Goetz M.
Site of the previous meiotic division defines cleavage orientation in the mouse embryo.
Nat Cell Biol. 2002 4:811-5. Pubmed
Grabarek JB, Wianny F, Plusa B, Zernicka-Goetz M, Glover DM.
RNA interference by production of short hairpin dsRNA in ES cells, their differentiated derivatives, and in somatic cell lines.
Biotechniques. 2003 34:734-6, 739-44. Pubmed
Zernicka-Goetz M.
Determining the first cleavage of the mouse zygote.
Reprod Biomed Online. 2003 6: 160-163. Pubmed
Durcova-Hills G, Wianny F, Merriman J, Zernicka-Goetz M, McLaren A.
Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro.
Differentiation. 2003 71:135-41. Pubmed
Piotrowska K, Zernicka-Goetz M.
Early patterning of the mouse embryo - contributions of sperm and egg. Development. 2002. 129:5803-13. Pubmed
Grabarek JB, Plusa B, Glover DM, Zernicka-Goetz M.
Efficient delivery of dsRNA into zona-enclosed mouse oocytes and preimplantation embryos by electroporation.Genesis, 2002. 32:269-76. Pubmed
Plusa B, Piotrowska K, Zernicka-Goetz M.
Sperm entry position provides a surface marker for the first cleavage plane of the mouse zygote. Genesis, 2002. 32:193-8. Pubmed
Zernicka-Goetz M.
Patterning of the embryo: the first spatial decisions in the life of a mouse. Development, 2000. 129:815-29. Pubmed
Piotrowska K, Wianny F, Pedersen RA, Zernicka-Goetz M.
Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development. Development, 2001. 128:3739-40. Pubmed
Zernicka-Goetz M, Pines J.
Use of Green Fluorescent Protein in mouse embryos. Methods 2000. 24:55-60. Pubmed
Piotrowska, K. and Zernicka-Goetz, M.
Role for sperm in spatial patterning of the early mouse embryo. Nature 2001. 409:517-521. Pubmed
Wianny, F and Zernicka-Goetz, M.
Specific interference with gene function by double stranded RNA in mouse. Nature Cell Biology, 2000. 2:70-75. Pubmed
Ciemerych MA, Mesnard D, Zernicka-Goetz M.
Animal and vegetal poles of the mouse egg predict the polarity of the embryonic axis, yet are nonessential for development. Development, 2000. 16:3467-74. Pubmed
Zernicka-Goetz M.
Jumping the gun on mouse gene expression. Nature, 2000. 6788:733. Pubmed
Grabarek J, Zernicka-Goetz M.
Progression of mouse oocytes from metaphase I to metaphase II is inhibited by fusion with G2 cells. Zygote, Zygote 2000. 8:145-51. Pubmed
Zernicka-Goetz M, Pines J.
Cell lineage analysis. Applications of green fluorescent protein. Methods Mol Biol, 2000. 135:279-87. Pubmed
Weber, R., Wianny, F., Evans, M.J., Pedersen, R., and Zernicka-Goetz, M.
Polarity of the mouse embryo is anticipated before implantation. Development, 1999. 126:5591-5598. Pubmed
Wianny F, Tavares A, Evans MJ, Glover DM, Zernicka-Goetz M.
Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation. Chromosoma, 1998. 6-7:430-9. Pubmed
Zernicka-Goetz M.
Fertile offspring derived from mammalian eggs lacking either animal or vegetal poles. Development, 1998. 23:4803-8. Pubmed
Zernicka-Goetz M, Pines J, McLean Hunter S, Dixon JP, Siemering KR, Haseloff J, Evans MJ.
Following cell fate in the living mouse embryo. Development, 1997. 6:1133-7. Pubmed
Zernicka-Goetz M, Verlhac MH, Geraud G, Kubiak JZ.
Protein phosphatases control MAP kinase activation and microtubule organization during rat oocyte maturation. Eur J Cell Biol. 1997. 1:30-8. Pubmed
Zernicka-Goetz M, Pines J, Ryan K, Siemering KR, Haseloff J, Evans MJ, Gurdon JB.
An indelible lineage marker for Xenopus using a mutated green fluorescent protein. Development. 1996. 2:3719-24. Pubmed
Zernicka-Goetz M, Ciemerych MA, Kubiak JZ, Tarkowski AK, Maro B.
Cytostatic factor inactivation is induced by a calcium-dependent mechanism present until the second cell cycle in fertilized but not in parthenogenetically activated mouse eggs. J Cell Sci. 1995. Pt 2:469-74. Pubmed
Zernicka-Goetz M.
Activation of embryonic genes during preimplantation rat development. Mol Reprod Dev, 1994. 1:30-5. Pubmed
Zernicka-Goetz M, Maro B.
Okadaic acid affects spindle organization in metaphase II-arrested rat oocytes. Exp Cell Res, 1993. 1:189-93. Pubmed
Zernicka-Goetz M, Weber M, Maro B.
Full activation of the rat oocyte by protein synthesis inhibition requires protein phosphatase activity. Int J Dev Biol. 1993. 2:273-7. Pubmed
Zernicka-Goetz M, Kubiak JZ, Antony C, Maro B.
Cytoskeletal organization of rat oocytes during metaphase II arrest and following abortive activation: a study by confocal laser scanning microscopy. Mol Reprod Dev, 1993. 2:165-75. Pubmed
Zernicka-Goetz M.
Spontaneous and induced activation of rat oocytes. Mol Reprod Dev. 1991. 2:169-76. Pubmed