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Research Directory

    Studying development to understand disease

    The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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    scmap: projection of single-cell RNA-seq data across data sets

    Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

    Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

    The developmental origin of brain tumours: a cellular and molecular framework

    Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing

    ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

    Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

    Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

    Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

    G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst

    Validating the concept of mutational signatures with isogenic cell models

    A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells

    Targeting NAT10 enhances healthspan and lifespan in a mouse model of human accelerated aging syndrome

    An alternative mode of epithelial polarity in the Drosophila midgut

    Detection of functional protein domains by unbiased genome-wide forward genetic screening

    Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium

    Genome organization at different scales: nature, formation and function

    Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations

     

    Link to full list on PubMed