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Drug repurposing for COVID-19  infographic for Han et al paper

A team led by researchers at the Milner Therapeutics Institute and Gurdon Institute used a combination of computational biology and machine learning to create a comprehensive map of proteins that are involved in SARS-CoV-2 infection. This analysis identified 200 drugs predicted to target SARS-CoV-2–induced pathways, 40 of which are already in COVID-19 clinical trials.

 

Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies

Han N et al. (2021) Science Advances  Vol. 7, no. 27, eabh3032. DOI: 10.1126/sciadv.abh3032.

 

Read the press release from the University of Cambridge

 

Abstract from the paper

The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates the rapid development of new therapies against coronavirus disease 2019 (COVID-19) infection.

Here, we present the identification of 200 approved drugs, appropriate for repurposing against COVID-19. We constructed a SARS-CoV-2–induced protein network, based on disease signatures defined by COVID-19 multiomics datasets, and cross-examined these pathways against approved drugs.

This analysis identified 200 drugs predicted to target SARS-CoV-2–induced pathways, 40 of which are already in COVID-19 clinical trials, testifying to the validity of the approach. Using artificial neural network analysis, we classified these 200 drugs into nine distinct pathways, within two overarching mechanisms of action (MoAs): viral replication (126) and immune response (74). Two drugs (proguanil and sulfasalazine) implicated in viral replication were shown to inhibit replication in cell assays.

This unbiased and validated analysis opens new avenues for the rapid repurposing of approved drugs into clinical trials.

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This research was performed at the Milner Therapeutics Institute (MTI) under the direction of Gurdon Institute group leader and MTI Director, Tony Kouzarides.