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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development

Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

Testing the role of SOX15 in human primordial germ cell fate

Genome architecture and stability in the Saccharomyces cerevisiae knockout collection

Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination

Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells

Disease modelling in human organoids

The role of integrins in Drosophila egg chamber morphogenesis

Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states

Neural stem cell dynamics: the development of brain tumours

Liver organoids: from basic research to therapeutic applications

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

The roles of DNA, RNA and histone methylation in ageing and cancer

Separating Golgi proteins from cis to trans reveals underlying properties of cisternal localization

Sequencing cell-type-specific transcriptomes with SLAM-ITseq

Mature sperm small-RNA profile in the sparrow: implications for transgenerational effects of age on fitness

Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction

Derivation and maintenance of mouse haploid embryonic stem cells

Establishment of porcine and human expanded potential stem cells

Adapting machine-learning algorithms to design gene circuits

Link to full list on PubMed