16.04.18 Rawlins lab identify two genes required for regulation of multiciliated cell differentiation
In this Biology Open paper, Johnson et al. developed an in vitro explant assay of embryonic mouse trachea to test over-expression of genes from multiciliated cells
05.04.18 Otsuki and Brand identify new stem cells that could aid regenerative medicine for brain repair
In this paper in Science, Otsuki and Brand report the discovery in the brain of a new type of quiescent stem cell (known as ‘G2 quiescent stem cell’) with higher regenerative potential than quiescent stem cells identified previously
29.03.18 In vitro model of human microglia derived from patient's stem cells developed in Livesey lab
This stem cell model of microglia, the brain’s macrophages, enabled the Livesey lab to examine the effects of mutations in the TREM2 receptor, which are causative for dementia
27.03.18 Livesey lab show that neurons take up single and aggregated tau molecules by two mechanisms
The transfer of aggregated tau between neurons was proposed to underlie the spread of pathology in dementia, but the Livesey lab show that neurons in vitro take up extracellular tau using endocytosis and micropinocytosis
27.03.18 Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting
Azim Surani of the Gurdon Institute and Davor Solter of the Max Planck Institute of Immunobiology and Epigenetics will receive Canada's top research award from the Gairdner Foundation in recognition of their work establishing the field of epigenetics with the discovery of genomic imprinting
19.03.18 Invitation to a special seminar by Jody Rosenblatt, Huntsman Cancer Institute, Utah, USA
Join us to hear about Jody Rosenblatt's research into the role of cell extrusion from epithelia, in health and disease
15.03.18 Using positional information to identify functions of long non-coding RNAs
The Kouzarides lab used a bioinformatics approach to identify hundreds of lncRNAs physically and functionally connected to developmental transcription sites
16.03.18 Invitation to a special seminar by Cayetano Gonzalez, IRB-Barcelona & Barcelona Institute of Science and Technology, Spain
Join us to hear Cayetano Gonzalez describe his research on experimentally induced tumours in Drosophila as a means to understand the molecular and cellular processes in neoplasia
14.03.18 Invitation to a special seminar by Julie Ahringer, Gurdon Institute
Join us to hear Julie Ahringer, Professor of Genetics and Genomics at the Gurdon Institute, describe her research on in vivo mechanisms that control chromatin architecture and gene expression in development
07.03.18 Invitation to a special seminar by Giacomo Cavalli, Institute of Human Genetics, Montpellier
Come and hear Giacomo Cavalli discuss his research in the fields of 3D genomics and epigenetic regulation, and present his future research goals
05.03.18 Invitation to a special seminar by Ross Cagan, Icahn School of Medicine at Mt Sinai, New York
Come and hear Ross Cagan describe his 'fly-to-bedside' approach of developing therapeutics based on models of disease in Drosophila
19.02.18 Invitation to a special seminar by Eric Miska, Gurdon Institute
Come and hear Eric Miska talk about his research on in-vivo RNA structures, including the Zika virus
26.02.18 Simons and Huch labs show how dynamics of biological systems offers new arena for statistical physics
This paper in Nature Physics shows that principles emerging from a study of cell lineage clusters can be mapped to the dynamics of aerosols
02.03.18 Invitation to a special seminar by Rama Khokha, University of Toronto
Come and hear Rama Khokha talk about her research on tissue homeostasis and its disintegration in cancer and disease
08.02.18 Two projects on the CRUK Grand Challenge shortlist feature Gurdon Institute scientists
Gurdon Institute researchers are part of two international teams whose projects have been selected onto the shortlist for CRUK's biggest research grants of £20 million, the 'Grand Challenge'
15.01.18 Insights into why mitochondrial diseases can strike previously unaffected families
The Surani lab with Patrick Chinnery and colleagues show in this Nature Cell Biology paper that egg precursor cells from healthy females harbour a small number of defects in mitochondrial DNA, that could lead to incurable disease
04.01.18 Glial cells create adaptive niche for neural stem cell lineages in Drosophila brain
In this Elife paper, Speder & Brand show how both nutritional and local cues stimulate cortex glial cells to create a membrane sheath around each proliferating neural stem cell lineage
22.12.17 Brand lab probes changes in chromatin state in developing brain using Targeted DamID
Brand lab's Nature Communication demonstrates large-scale chromatin remodelling in Drosophila neural development
18.12.17 Novel method for detecting cell-type-specific lncRNA-genome interactions
In this Nature Structural and Molecular Biology article, Cheetham and Brand demonstrate an effective technique to examine the role of lncRNA-chromatin interactions
12.12.17 And the 2018 Women in Cell Biology Early Career Medal goes to...Meritxell Huch
Awarded by the British Society for Cell Biology, the annual Women in Cell Biology Medal honours the most promising early career female researchers, to serve as inspiring role models for the next generation
12.11.17 Cancer theory revisited and debated at interdisciplinary workshop in Austria
A 'revised theory of cancer' was discussed at an international workshop in Austria by a high-profile group of cancer cell biologists, clinicians and data scientists to assess the need for a new theoretical paradigm in cancer research
27.11.17 METTL3 is an unforeseen new drug target for Acute Myeloid Leukaemia
The Kouzarides lab and colleagues, in this Nature paper, describe their discovery of a specific drug target for acute myeloid leukaemia
27.10.17 Surani lab and colleagues derive 'advanced' pluripotent stem cells
In this Cell Research paper the Surani lab describe cells, derived from blastocysts, that exhibit an intermediate potency state between pre- and post-implantation stem cells
26.10.17 Cyclin B1's essential role in mitosis and the timing of entry into mitosis
Bernhard Strauss of the former Pines lab and collegues show in this J Cell Biol paper that Cyclin B1 is required for cell division in mouse embryos
13.11.17 Tumour organoids created from patients' liver cancers by Huch lab and colleagues
Mini liver tumours created in a dish for the first time, described in Nature Medicine paper from the Huch lab
16.10.17 Role for dynactin in protecting microtubules to deliver oskar mRNA to the oocyte posterior
In this eLife paper the St Johnston lab with Cambridge colleagues describe a role for dynactin as an 'anti-catastrophe' factor in oocyte polarisation
03.11.17 X-chromosome reactivation in the inner cell mass happens at different stages for different genes
Borensztein et al. show in this Nature Communications paper that different genes on the paternal X-chromosome may be reactivated by transcription factors or active erasure of chromatin marks
21.09.17 Simons and Hannezo reveal a unifying theory for branching patterns in tissue
In this Cell paper, Ben Simons and Edouard Hannezo and colleagues show how the growth of ductal networks in different organs can be described by simple statistical rules
18.09.17 Building actin filaments using phosphoinositide lipids and high membrane curvature
In this JCB article the Gallop lab and colleagues use advanced fluorescence microscopy to follow the biochemistry of actin polymerisation on membranes
07.08.17 Miska lab tease out role of RNA helicase Aquarius in heritable transcriptional silencing
In this Developmental Cell paper, Akay et al. show that Aquarius/EMB-4 is a direct and essential link between small RNA pathways and the transcriptional machinery in C. elegans
