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21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance

21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance

This study from the Miska lab, with colleagues at Imperial, provides a first reference of house sparrow sperm small RNA as an attempt to uncover their role in the transmission of the effects of paternal age on the offspring.

21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance - Read More…

27.04.19 Discovering gene circuits using machine-learning algorithms

27.04.19 Discovering gene circuits using machine-learning algorithms

Tom Hiscock in the Simons group applied a computational approach to generate algorithms describing natural gene circuits and for designing circuits in synthetic biology. The work is published in BMC Bioinformatics

27.04.19 Discovering gene circuits using machine-learning algorithms - Read More…

29.05.19 Bipotent stem cells in embryonic liver give rise to hepatocytes and cholangiocytes

Prior et al. in the Huch and Simons labs use lineage tracing, sc-RNA seq and organoid culture to show that Lgr5 is a marker for a sub-population of bipotent liver progenitor cells

29.05.19 Bipotent stem cells in embryonic liver give rise to hepatocytes and cholangiocytes - Read More…

06.10.18 International honour for Tony Kouzarides from learned society in the USA

Senior group leader Prof Tony Kouzarides has been elected an International Honorary Member of the American Academy of Arts and Sciences.

06.10.18 International honour for Tony Kouzarides from learned society in the USA - Read More…

02.04.19 Citrullination of heterochromatin protein 1 gamma diminishes when stem cells differentiate

02.04.19 Citrullination of heterochromatin protein 1 gamma diminishes when stem cells differentiate

The Kouzarides lab and colleagues identify citrullination of HP1γ within its chromodomain as a novel post-translational modification in mouse embryonic stem cells (mESCs) that is dynamically regulated during mESC differentiation.

02.04.19 Citrullination of heterochromatin protein 1 gamma diminishes when stem cells differentiate - Read More…

02.05.19 Transmissible RNA pathway in honey bees offers potential route for bee 'vaccines'

Eyal Maori with the Miska lab and collaborators in Israel, the USA and UK show that honey bees share genetic material via their equivalent of mother's milk, allowing spread between colony members. In addition, the scientists identify the chemical composition of an RNA-stabilising protein in royal jelly that protects the RNA when outside the body

02.05.19 Transmissible RNA pathway in honey bees offers potential route for bee 'vaccines' - Read More…

25.04.19 m7G is a new RNA-modification pathway with phenotypic effects

The Kouzarides lab identify a METTL1-dependent modification of RNA, N7-methylation of guanosine, as a new modification pathway regulating miRNA structure and biogenesis, with a phenotypic effect on cancer cell migration

25.04.19 m7G is a new RNA-modification pathway with phenotypic effects - Read More…

06.04.19 Ten years since first ever single-cell RNA seq paper - from the Gurdon Institute

06.04.19 Ten years since first ever single-cell RNA seq paper - from the Gurdon Institute

The technique for examining all the gene products in one cell at one timepoint, single-cell RNA sequencing, was established right here at the Gurdon Institute in Azim Surani's lab. The method was published on 6 April 2009; below is the abstract and a recent paper analysing successive developments in the technique.

06.04.19 Ten years since first ever single-cell RNA seq paper - from the Gurdon Institute - Read More…

26.03.19 Identifying locations and homogeneity of N-6 methylated deoxyadenosine

26.03.19 Identifying locations and homogeneity of N-6 methylated deoxyadenosine

Pacini et al. from the Gurdon lab have mapped the novel DNA modification m6dA at nucleotiode level in the human genome, showing that this low-abundance mark occurs precisely and consistently

26.03.19 Identifying locations and homogeneity of N-6 methylated deoxyadenosine - Read More…

21.03.19 Neural stem cell activation speed depends on position in brain

21.03.19 Neural stem cell activation speed depends on position in brain

Otsuki and Brand show that in the Drosophila brain, the speed at which stem cells can be activated to start diving depends on their dorsal-ventral location, an important consideration in designing regeneration therapies

21.03.19 Neural stem cell activation speed depends on position in brain - Read More…

18.02.19 Miska lab identify hundreds of new non-coding RNAs and prove biological activity in several

C elegans is the model of choice for identifying long non-coding RNAs and investigating whether their deletion has biological effects. The Miska lab, with the Earlham Institute, find several that affect growth and fertility.

18.02.19 Miska lab identify hundreds of new non-coding RNAs and prove biological activity in several - Read More…

28.02.19 Extending Turing's reaction-diffusion model with mechanics, for robust tissue patterning during development

28.02.19 Extending Turing's reaction-diffusion model with mechanics, for robust tissue patterning during development

The Simons lab, with colleagues in France and Austria, devise a new model for tissue patterning, proposing that mechanical forces work in combination with chemical gradients to generate spatial patterns

28.02.19 Extending Turing's reaction-diffusion model with mechanics, for robust tissue patterning during development - Read More…

21.02.19 Miska lab find sex differences in gene silencing by environmental RNA

21.02.19 Miska lab find sex differences in gene silencing by environmental RNA

Using C elegans as a model, the Miska lab and colleagues show clear differences between sexes in small RNA abundance that are associated with trans-generational inheritance

21.02.19 Miska lab find sex differences in gene silencing by environmental RNA - Read More…

22.02.19 Physical and molecular underpinnings of proneural wave in Drosophila optic lobe

22.02.19 Physical and molecular underpinnings of proneural wave in Drosophila optic lobe

The Simons and Brand labs combine expertise to show that a reaction-diffusion mechanism underlies a travelling wave of gene expression that turns neuroepithelial cells into neuroblasts

22.02.19 Physical and molecular underpinnings of proneural wave in Drosophila optic lobe - Read More…

15.01.19 Dementia mediated by tau mutations shows abnormalities in nuclear membranes

15.01.19 Dementia mediated by tau mutations shows abnormalities in nuclear membranes

Livesey and Jackson lab collaboration shows that mutations in tau protein underlying frontotemporal dementia result in nuclear membrane dysfunction in neurons, with disrupted nucleo-cytoplasmic transport

15.01.19 Dementia mediated by tau mutations shows abnormalities in nuclear membranes - Read More…

11.01.19 Role for RNA-binding protein IMP in the fine control of Drosophila egg chamber development

11.01.19 Role for RNA-binding protein IMP in the fine control of Drosophila egg chamber development

The St Johnston lab uncover a novel regulatory step in the Notch signalling pathway in follicle cells, whereby localisation of Kuzbanian to the apical domain promotes Notch cleavage, inducing cell differentiation

11.01.19 Role for RNA-binding protein IMP in the fine control of Drosophila egg chamber development - Read More…

08.01.2019 Compensating for loss of neurodegenerative disease gene ATM offers insights into cancer drug resistance

08.01.2019 Compensating for loss of neurodegenerative disease gene ATM offers insights into cancer drug resistance

The Jackson lab and collaborators have identified mechanisms by which drug sensitivities characteristic of ATM-deficient cells can be counteracted by changes in other genes. These results can help shed light on cancer drug resistance and suggest potential therapeutic targets for the genetic disease, ataxia-telangiectasia.

08.01.2019 Compensating for loss of neurodegenerative disease gene ATM offers insights into cancer drug resistance - Read More…

26.12.18 Lysosome and autophagy defects are causes of neuronal dysfunction in Alzheimer's Disease

26.12.18 Lysosome and autophagy defects are causes of neuronal dysfunction in Alzheimer's Disease

The Livesey lab show that single gene defects in early onset Alzheimer's lead to disrupted lysosome and autophagosome function in human cortical neurons

26.12.18 Lysosome and autophagy defects are causes of neuronal dysfunction in Alzheimer's Disease - Read More…

27.12.18 Cdc45 targets Rad53 to distinct replication complexes in budding yeast

27.12.18 Cdc45 targets Rad53 to distinct replication complexes in budding yeast

In this Molecular Cell paper, the Zegerman lab present a single mechanism by which a checkpoint kinase targets replication initiation and elongation complexes, which may be relevant to human disease

27.12.18 Cdc45 targets Rad53 to distinct replication complexes in budding yeast - Read More…

19.12.18 Potential for new eye drop medicine to help Acute Myeloid Leukemia

19.12.18 Potential for new eye drop medicine to help Acute Myeloid Leukemia

A new study in Nature Communications describes a novel mechanism required for leukaemia cell survival and highlights the therapeutic potential of SRPK1 inhibition in an aggressive type of AML.

19.12.18 Potential for new eye drop medicine to help Acute Myeloid Leukemia - Read More…

19.12.18 Transcription complex proteins gain novel function to drive genome defence against transposons

In this Genes & Development article, the Miska and Ahringer labs with colleagues in China and Germany show how four proteins with ancestral functions combine in a complex that is essential for production of piRNAs

19.12.18 Transcription complex proteins gain novel function to drive genome defence against transposons - Read More…

22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain

22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain

The Brand lab publish in Neural Development on the dynamic regulation of Notch signalling in the transition from optic lobe neuroepithelial cells to asymmetrically dividing neural stem cells

22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain - Read More…

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery

The Kouzarides and Jackson labs tease out the series of biochemical events, including a histone modification, that allows cells to recover from the DNA damage checkpoint

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery - Read More…

26.10.18 Mapping regulatory elements across the C. elegans lifespan

26.10.18 Mapping regulatory elements across the C. elegans lifespan

The Ahringer lab and international colleagues used multiple assays to systematically identify and annotate accessible chromatin in the six C. elegans developmental stages and at five time points of adult ageing

26.10.18 Mapping regulatory elements across the C. elegans lifespan - Read More…

31.10.18 Cell polarisation of fly midgut epithelium provides better model for mammalian epithelia

The St Johnston lab's discovery of the mechanism for epithelial cell polarisation in the fly gut disproves the idea that the same conserved system establishes apical-basal polarity in all epithelia

31.10.18 Cell polarisation of fly midgut epithelium provides better model for mammalian epithelia - Read More…

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice

The Miska lab with colleagues in Switzerland show that early life trauma can cause alterations in long RNA in mouse sperm, and this contributes to transmitting the effects to the next generation

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice - Read More…