18.08.18 Resolving the cellular basis of mouse pancreas development
The Simons and Huch labs, with Cambridge Stem Cell Institute colleagues, tease out the cellular mechanisms by which the pancreas develops its branched ductal structures
10.07.18 Chromatin accessibility is a central factor in successful reprogramming in oocytes
In this Cell Reports article the Gurdon and Livesey labs show an association between the local chromatin state and whether genes are activated by or resistant to reprogramming
18.07.18 'Shieldin' protein complex identified that affects response of BRCA1-negative cells to PARP inhibitors
The Jackson lab, with an international team of collaborators, show that testing for levels of the Shieldin complex in BRCA1 mutant tumours could help predict response to anti-cancer therapy
18.07.18 Genome-scale oscillations in DNA methylation as cells undergo fate decisions
The Simons lab with colleagues from the Babraham Institute combined single-cell sequencing and biophysical modelling to follow DNA methylation states as cells begin to differentiate
03.07.18 Identifying and targeting a nuclear transport pathway affected in premature and healthy ageing
The Jackson and Kouzarides labs present a model for how NAT10 inhibition rescues cells with phenotypes of the premature ageing disease Hutchinson-Gilford progeria syndrome
26.06.18 New method for sequencing cell type-specific transcriptomes without cell sorting
In this Development report, Matsushima et al. present their new technique based on using a cell-specific promoter for in vivo metabolic RNA sequencing without cell sorting or RNA isolation
19.06.18 RNA-binding protein SRSF3 shown to regulate the maternal transcriptome in mouse oocyte
The Surani lab, with colleagues in Cambridge, Norwich, London and Singapore, highlight the role of RNA-binding proteins in controlling the maternal transcriptome for correct development of fertilised oocytes
10.05.18 Surani lab show epigenetic modifier G9a is vital in preimplanation embryo development
In this eLife paper the Surani lab examine effects of loss of maternally inherited G9a on regulation of cell fate choices at onset of embryo development
27.04.18 Mouse study identifies new target for increasing health and lifespan in a human accelerated ageing syndrome
The Jackson lab, working with colleagues at Wellcome Sanger Institute, have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome
27.03.18 Ben Simons awarded Royal Society EP Abraham Research Professorship
In March the Royal Society announced the latest awards of coveted professorships to six world-class scientists, with Ben Simons of the Gurdon Institute among them
18.04.18 Jackson lab establishes method to detect spontaneous or chemically-induced suppressor mutations
In this Scientific Report, Herzog et al. of the Jackson lab demonstrate a method of detecting functional protein domains that can be used to identify drug targets and predict resistance mechanisms
24.04.18 Invitation to our special event at Kettle's Yard on 12th May 2018
Come along to hear from the artists and scientists involved in our collaborative project, 'Experiments in Art and Science'
16.04.18 Rawlins lab identify two genes required for regulation of multiciliated cell differentiation
In this Biology Open paper, Johnson et al. developed an in vitro explant assay of embryonic mouse trachea to test over-expression of genes from multiciliated cells
05.04.18 Otsuki and Brand identify new stem cells that could aid regenerative medicine for brain repair
In this paper in Science, Otsuki and Brand report the discovery in the brain of a new type of quiescent stem cell (known as ‘G2 quiescent stem cell’) with higher regenerative potential than quiescent stem cells identified previously
29.03.18 In vitro model of human microglia derived from patient's stem cells developed in Livesey lab
This stem cell model of microglia, the brain’s macrophages, enabled the Livesey lab to examine the effects of mutations in the TREM2 receptor, which are causative for dementia
27.03.18 Livesey lab show that neurons take up single and aggregated tau molecules by two mechanisms
The transfer of aggregated tau between neurons was proposed to underlie the spread of pathology in dementia, but the Livesey lab show that neurons in vitro take up extracellular tau using endocytosis and micropinocytosis
27.03.18 Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting
Azim Surani of the Gurdon Institute and Davor Solter of the Max Planck Institute of Immunobiology and Epigenetics will receive Canada's top research award from the Gairdner Foundation in recognition of their work establishing the field of epigenetics with the discovery of genomic imprinting
19.03.18 Invitation to a special seminar by Jody Rosenblatt, Huntsman Cancer Institute, Utah, USA
Join us to hear about Jody Rosenblatt's research into the role of cell extrusion from epithelia, in health and disease
15.03.18 Using positional information to identify functions of long non-coding RNAs
The Kouzarides lab used a bioinformatics approach to identify hundreds of lncRNAs physically and functionally connected to developmental transcription sites
16.03.18 Invitation to a special seminar by Cayetano Gonzalez, IRB-Barcelona & Barcelona Institute of Science and Technology, Spain
Join us to hear Cayetano Gonzalez describe his research on experimentally induced tumours in Drosophila as a means to understand the molecular and cellular processes in neoplasia
14.03.18 Invitation to a special seminar by Julie Ahringer, Gurdon Institute
Join us to hear Julie Ahringer, Professor of Genetics and Genomics at the Gurdon Institute, describe her research on in vivo mechanisms that control chromatin architecture and gene expression in development
07.03.18 Invitation to a special seminar by Giacomo Cavalli, Institute of Human Genetics, Montpellier
Come and hear Giacomo Cavalli discuss his research in the fields of 3D genomics and epigenetic regulation, and present his future research goals
05.03.18 Invitation to a special seminar by Ross Cagan, Icahn School of Medicine at Mt Sinai, New York
Come and hear Ross Cagan describe his 'fly-to-bedside' approach of developing therapeutics based on models of disease in Drosophila
19.02.18 Invitation to a special seminar by Eric Miska, Gurdon Institute
Come and hear Eric Miska talk about his research on in-vivo RNA structures, including the Zika virus
26.02.18 Simons and Huch labs show how dynamics of biological systems offers new arena for statistical physics
This paper in Nature Physics shows that principles emerging from a study of cell lineage clusters can be mapped to the dynamics of aerosols
02.03.18 Invitation to a special seminar by Rama Khokha, University of Toronto
Come and hear Rama Khokha talk about her research on tissue homeostasis and its disintegration in cancer and disease
08.02.18 Two projects on the CRUK Grand Challenge shortlist feature Gurdon Institute scientists
Gurdon Institute researchers are part of two international teams whose projects have been selected onto the shortlist for CRUK's biggest research grants of £20 million, the 'Grand Challenge'
15.01.18 Insights into why mitochondrial diseases can strike previously unaffected families
The Surani lab with Patrick Chinnery and colleagues show in this Nature Cell Biology paper that egg precursor cells from healthy females harbour a small number of defects in mitochondrial DNA, that could lead to incurable disease
04.01.18 Glial cells create adaptive niche for neural stem cell lineages in Drosophila brain
In this Elife paper, Speder & Brand show how both nutritional and local cues stimulate cortex glial cells to create a membrane sheath around each proliferating neural stem cell lineage
22.12.17 Brand lab probes changes in chromatin state in developing brain using Targeted DamID
Brand lab's Nature Communication demonstrates large-scale chromatin remodelling in Drosophila neural development
