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15.01.19 Dementia mediated by tau mutations shows abnormalities in nuclear membranes

15.01.19 Dementia mediated by tau mutations shows abnormalities in nuclear membranes

Livesey and Jackson lab collaboration shows that mutations in tau protein underlying frontotemporal dementia result in nuclear membrane dysfunction in neurons, with disrupted nucleo-cytoplasmic transport

15.01.19 Dementia mediated by tau mutations shows abnormalities in nuclear membranes - Read More…

11.01.19 Role for RNA-binding protein IMP in the fine control of Drosophila egg chamber development

11.01.19 Role for RNA-binding protein IMP in the fine control of Drosophila egg chamber development

The St Johnston lab uncover a novel regulatory step in the Notch signalling pathway in follicle cells, whereby localisation of Kuzbanian to the apical domain promotes Notch cleavage, inducing cell differentiation

11.01.19 Role for RNA-binding protein IMP in the fine control of Drosophila egg chamber development - Read More…

08.01.2019 Compensating for loss of neurodegenerative disease gene ATM offers insights into cancer drug resistance

08.01.2019 Compensating for loss of neurodegenerative disease gene ATM offers insights into cancer drug resistance

The Jackson lab and collaborators have identified mechanisms by which drug sensitivities characteristic of ATM-deficient cells can be counteracted by changes in other genes. These results can help shed light on cancer drug resistance and suggest potential therapeutic targets for the genetic disease, ataxia-telangiectasia.

08.01.2019 Compensating for loss of neurodegenerative disease gene ATM offers insights into cancer drug resistance - Read More…

26.12.18 Lysosome and autophagy defects are causes of neuronal dysfunction in Alzheimer's Disease

26.12.18 Lysosome and autophagy defects are causes of neuronal dysfunction in Alzheimer's Disease

The Livesey lab show that single gene defects in early onset Alzheimer's lead to disrupted lysosome and autophagosome function in human cortical neurons

26.12.18 Lysosome and autophagy defects are causes of neuronal dysfunction in Alzheimer's Disease - Read More…

27.12.18 Cdc45 targets Rad53 to distinct replication complexes in budding yeast

27.12.18 Cdc45 targets Rad53 to distinct replication complexes in budding yeast

In this Molecular Cell paper, the Zegerman lab present a single mechanism by which a checkpoint kinase targets replication initiation and elongation complexes, which may be relevant to human disease

27.12.18 Cdc45 targets Rad53 to distinct replication complexes in budding yeast - Read More…

19.12.18 Potential for new eye drop medicine to help Acute Myeloid Leukemia

19.12.18 Potential for new eye drop medicine to help Acute Myeloid Leukemia

A new study in Nature Communications describes a novel mechanism required for leukaemia cell survival and highlights the therapeutic potential of SRPK1 inhibition in an aggressive type of AML.

19.12.18 Potential for new eye drop medicine to help Acute Myeloid Leukemia - Read More…

19.12.18 Transcription complex proteins gain novel function to drive genome defence against transposons

In this Genes & Development article, the Miska and Ahringer labs with colleagues in China and Germany show how four proteins with ancestral functions combine in a complex that is essential for production of piRNAs

19.12.18 Transcription complex proteins gain novel function to drive genome defence against transposons - Read More…

22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain

22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain

The Brand lab publish in Neural Development on the dynamic regulation of Notch signalling in the transition from optic lobe neuroepithelial cells to asymmetrically dividing neural stem cells

22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain - Read More…

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery

The Kouzarides and Jackson labs tease out the series of biochemical events, including a histone modification, that allows cells to recover from the DNA damage checkpoint

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery - Read More…

26.10.18 Mapping regulatory elements across the C. elegans lifespan

26.10.18 Mapping regulatory elements across the C. elegans lifespan

The Ahringer lab and international colleagues used multiple assays to systematically identify and annotate accessible chromatin in the six C. elegans developmental stages and at five time points of adult ageing

26.10.18 Mapping regulatory elements across the C. elegans lifespan - Read More…

31.10.18 Cell polarisation of fly midgut epithelium provides better model for mammalian epithelia

The St Johnston lab's discovery of the mechanism for epithelial cell polarisation in the fly gut disproves the idea that the same conserved system establishes apical-basal polarity in all epithelia

31.10.18 Cell polarisation of fly midgut epithelium provides better model for mammalian epithelia - Read More…

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice

The Miska lab with colleagues in Switzerland show that early life trauma can cause alterations in long RNA in mouse sperm, and this contributes to transmitting the effects to the next generation

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice - Read More…

16.10.18 CRISPR screen identifies further genes that regulate mouse germ cell specification

16.10.18 CRISPR screen identifies further genes that regulate mouse germ cell specification

A team of current and former Surani lab researchers apply fluorescent reporters with a genome-wide CRISPR screen to track changing cellular identity in a model of developing primordial germ cells

16.10.18 CRISPR screen identifies further genes that regulate mouse germ cell specification - Read More…

11.10.18 Scientists watch development of lab-engineered human neurons transplanted into mouse brain

11.10.18 Scientists watch development of lab-engineered human neurons transplanted into mouse brain

Livesey lab and colleagues' technique for transplanting engineered human brain cells in mice, published in Science, provides insights into Down syndrome, with potential wider application

11.10.18 Scientists watch development of lab-engineered human neurons transplanted into mouse brain - Read More…

26.09.18 Role for alpha-ketoglutate in pluripotency and germ cell specification

26.09.18 Role for alpha-ketoglutate in pluripotency and germ cell specification

The Surani lab, with colleagues in Cambridge and Germany, demonstrate a link between epigenetic control of germ cell specification and the mitochondrial oxidative metabolite, alpha-ketoglutarate

26.09.18 Role for alpha-ketoglutate in pluripotency and germ cell specification - Read More…

25.09.18 The optic lobe neuroepithelium generates neural stem cells over 60 hours earlier than previously thought

25.09.18 The optic lobe neuroepithelium generates neural stem cells over 60 hours earlier than previously thought

Hakes, Otsuki and Brand show that neuroepithelial cells in the Drosophila optic lobe produce previously unidentified neural stem cells during embryonic development

25.09.18 The optic lobe neuroepithelium generates neural stem cells over 60 hours earlier than previously thought - Read More…

08.09.18 Branching gene expression in response to infection analysed with Gaussian processes

08.09.18 Branching gene expression in response to infection analysed with Gaussian processes

Penfold et al from the Surani lab apply statistical methods to understand patterns in changes in gene expression following perturbations such as infection

08.09.18 Branching gene expression in response to infection analysed with Gaussian processes - Read More…

10.09.18 New technique reveals how Zika interacts inside cells and could enable new anti-viral therapies

The COMRADES technique, developed by the Miska lab with international colleagues, can screen for host–virus RNA base-pairing and reveal the interacting sequences of RNA in a single experiment. In this Nature Methods paper they apply it to the Zika virus in human cells.

10.09.18 New technique reveals how Zika interacts inside cells and could enable new anti-viral therapies - Read More…

13.08.18 Antiviral gene screen in C elegans reveals third mechanism for antiviral defence

13.08.18 Antiviral gene screen in C elegans reveals third mechanism for antiviral defence

The Miska lab, with UK and USA collaborators, developed a system for antiviral gene discovery and identified 3'-terminal uridylation of viral RNAs as a defence mechanism in animals

13.08.18 Antiviral gene screen in C elegans reveals third mechanism for antiviral defence - Read More…

21.06.18 RNA helicase DDX3X is indirect regulator of breast cancer cell cycle

21.06.18 RNA helicase DDX3X is indirect regulator of breast cancer cell cycle

The Kouzarides lab identify how DDX3X plays oncogenic role in breast cancer cells via effect on expression and downstream function of KLF4

21.06.18 RNA helicase DDX3X is indirect regulator of breast cancer cell cycle - Read More…

18.08.18 Resolving the cellular basis of mouse pancreas development

18.08.18 Resolving the cellular basis of mouse pancreas development

The Simons and Huch labs, with Cambridge Stem Cell Institute colleagues, tease out the cellular mechanisms by which the pancreas develops its branched ductal structures

18.08.18 Resolving the cellular basis of mouse pancreas development - Read More…

10.07.18 Chromatin accessibility is a central factor in successful reprogramming in oocytes

10.07.18 Chromatin accessibility is a central factor in successful reprogramming in oocytes

In this Cell Reports article the Gurdon and Livesey labs show an association between the local chromatin state and whether genes are activated by or resistant to reprogramming

10.07.18 Chromatin accessibility is a central factor in successful reprogramming in oocytes - Read More…

18.07.18 'Shieldin' protein complex identified that affects response of BRCA1-negative cells to PARP inhibitors

The Jackson lab, with an international team of collaborators, show that testing for levels of the Shieldin complex in BRCA1 mutant tumours could help predict response to anti-cancer therapy

18.07.18 'Shieldin' protein complex identified that affects response of BRCA1-negative cells to PARP inhibitors - Read More…

18.07.18 Genome-scale oscillations in DNA methylation as cells undergo fate decisions

18.07.18 Genome-scale oscillations in DNA methylation as cells undergo fate decisions

The Simons lab with colleagues from the Babraham Institute combined single-cell sequencing and biophysical modelling to follow DNA methylation states as cells begin to differentiate

18.07.18 Genome-scale oscillations in DNA methylation as cells undergo fate decisions - Read More…

03.07.18 Identifying and targeting a nuclear transport pathway affected in premature and healthy ageing

03.07.18 Identifying and targeting a nuclear transport pathway affected in premature and healthy ageing

The Jackson and Kouzarides labs present a model for how NAT10 inhibition rescues cells with phenotypes of the premature ageing disease Hutchinson-Gilford progeria syndrome

03.07.18 Identifying and targeting a nuclear transport pathway affected in premature and healthy ageing - Read More…

26.06.18 New method for sequencing cell type-specific transcriptomes without cell sorting

26.06.18 New method for sequencing cell type-specific transcriptomes without cell sorting

In this Development report, Matsushima et al. present their new technique based on using a cell-specific promoter for in vivo metabolic RNA sequencing without cell sorting or RNA isolation

26.06.18 New method for sequencing cell type-specific transcriptomes without cell sorting - Read More…

19.06.18 RNA-binding protein SRSF3 shown to regulate the maternal transcriptome in mouse oocyte

19.06.18 RNA-binding protein SRSF3 shown to regulate the maternal transcriptome in mouse oocyte

The Surani lab, with colleagues in Cambridge, Norwich, London and Singapore, highlight the role of RNA-binding proteins in controlling the maternal transcriptome for correct development of fertilised oocytes

19.06.18 RNA-binding protein SRSF3 shown to regulate the maternal transcriptome in mouse oocyte - Read More…