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27.10.17 Surani lab and colleagues derive 'advanced' pluripotent stem cells

27.10.17 Surani lab and colleagues derive 'advanced' pluripotent stem cells

In this Cell Research paper the Surani lab describe cells, derived from blastocysts, that exhibit an intermediate potency state between pre- and post-implantation stem cells

27.10.17 Surani lab and colleagues derive 'advanced' pluripotent stem cells - Read More…

26.10.17 Cyclin B1's essential role in mitosis and the timing of entry into mitosis

26.10.17 Cyclin B1's essential role in mitosis and the timing of entry into mitosis

Bernhard Strauss of the former Pines lab and collegues show in this J Cell Biol paper that Cyclin B1 is required for cell division in mouse embryos

26.10.17 Cyclin B1's essential role in mitosis and the timing of entry into mitosis - Read More…

16.10.17 Role for dynactin in protecting microtubules to deliver oskar mRNA to the oocyte posterior

16.10.17 Role for dynactin in protecting microtubules to deliver oskar mRNA to the oocyte posterior

In this eLife paper the St Johnston lab with Cambridge colleagues describe a role for dynactin as an 'anti-catastrophe' factor in oocyte polarisation

16.10.17 Role for dynactin in protecting microtubules to deliver oskar mRNA to the oocyte posterior - Read More…

03.11.17 X-chromosome reactivation in the inner cell mass happens at different stages for different genes

03.11.17 X-chromosome reactivation in the inner cell mass happens at different stages for different genes

Borensztein et al. show in this Nature Communications paper that different genes on the paternal X-chromosome may be reactivated by transcription factors or active erasure of chromatin marks

03.11.17 X-chromosome reactivation in the inner cell mass happens at different stages for different genes - Read More…

21.09.17 Simons and Hannezo reveal a unifying theory for branching patterns in tissue

21.09.17 Simons and Hannezo reveal a unifying theory for branching patterns in tissue

In this Cell paper, Ben Simons and Edouard Hannezo and colleagues show how the growth of ductal networks in different organs can be described by simple statistical rules

21.09.17 Simons and Hannezo reveal a unifying theory for branching patterns in tissue - Read More…

18.09.17 Building actin filaments using phosphoinositide lipids and high membrane curvature

18.09.17 Building actin filaments using phosphoinositide lipids and high membrane curvature

In this JCB article the Gallop lab and colleagues use advanced fluorescence microscopy to follow the biochemistry of actin polymerisation on membranes

18.09.17 Building actin filaments using phosphoinositide lipids and high membrane curvature - Read More…

07.08.17 Miska lab tease out role of RNA helicase Aquarius in heritable transcriptional silencing

07.08.17 Miska lab tease out role of RNA helicase Aquarius in heritable transcriptional silencing

In this Developmental Cell paper, Akay et al. show that Aquarius/EMB-4 is a direct and essential link between small RNA pathways and the transcriptional machinery in C. elegans

07.08.17 Miska lab tease out role of RNA helicase Aquarius in heritable transcriptional silencing - Read More…

05.09.17 Ufuk Günesdogan wins €1.65 M career development award

05.09.17 Ufuk Günesdogan wins €1.65 M career development award

The 2017 Sofja Kovalevskaja Awards have been announced and a Gurdon Institute postdoc in the Surani lab is one of the six winners

05.09.17 Ufuk Günesdogan wins €1.65 M career development award - Read More…

14.08.17 New model of human lung development provided by Rawlins lab organoid system

14.08.17 New model of human lung development provided by Rawlins lab organoid system

In this eLife paper Emma Rawlins' lab, with colleagues in Cambridge and London, describe their new human lung distal tip epithelium cultures

14.08.17 New model of human lung development provided by Rawlins lab organoid system - Read More…

08.08.2017 Buffering role for miR-7 in developing optic lobe

08.08.2017 Buffering role for miR-7 in developing optic lobe

In this Cell Reports paper, Caygill and Brand present evidence that the transformation of neuroepithelial cells into neural stem cells in the developing optic lobe of the brain is buffered against environmental stress by the microRNA miR-7.

08.08.2017 Buffering role for miR-7 in developing optic lobe - Read More…

19.07.17 Huch lab wins project grant to develop patient-specific 'liver cancer organoids'

19.07.17 Huch lab wins project grant to develop patient-specific 'liver cancer organoids'

The NC3Rs has awarded a project grant to Meri Huch to explore how to grow liver cancer organoids from tumour biopsies, replacing the use of animals for such research

19.07.17 Huch lab wins project grant to develop patient-specific 'liver cancer organoids' - Read More…

10.07.17 Chk1 orchestrates regulation of cell cycle length at mid-blastula transition by inhibiting Drf1

10.07.17 Chk1 orchestrates regulation of cell cycle length at mid-blastula transition by inhibiting Drf1

In this Dev Cell paper the Zegerman lab, with collaborator Jim Smith at the Crick, describe a role for checkpoint kinase Chk1 in the mid-blastula transition in Xenopus

10.07.17 Chk1 orchestrates regulation of cell cycle length at mid-blastula transition by inhibiting Drf1 - Read More…

31.05.17 Probing regulation of gene transcription with a computer model

31.05.17 Probing regulation of gene transcription with a computer model

Namshik Han from the Kouzarides lab, with Manchester colleagues, presents a computer model for identifying new members of transcription factor networks and new interactions between members.

31.05.17 Probing regulation of gene transcription with a computer model - Read More…

07.06.17 Pinning down the origin of human primordial germ cells with the help of pig embryos

07.06.17 Pinning down the origin of human primordial germ cells with the help of pig embryos

This Nature paper from the Surani lab and colleagues shows how the precursors of egg and sperm cells arise in the embryo, by using human cells in vitro and pig embryos ex vivo

07.06.17 Pinning down the origin of human primordial germ cells with the help of pig embryos - Read More…

06.06.17 Embryonic stem cells exhibit a spectrum of pluripotent states

06.06.17 Embryonic stem cells exhibit a spectrum of pluripotent states

The Surani lab show how embryonic stem cells can be coaxed into adopting many different pluripotent states, which influence their response to differentiation

06.06.17 Embryonic stem cells exhibit a spectrum of pluripotent states - Read More…

27.04.17 Winners of our Zoom Box photo competition announced

Images taken with Zoom Boxes assembled at our Science Festival event have now been judged and prizes are on their way

27.04.17 Winners of our Zoom Box photo competition announced - Read More…

21.03.17 Surani lab show role for maternally inherited protein, Stella

21.03.17 Surani lab show role for maternally inherited protein, Stella

In this eLife paper, the Surani lab with EMBL colleagues show that Stella controls activation of transposable elements in the developing embryo

21.03.17 Surani lab show role for maternally inherited protein, Stella - Read More…

27.03.17 Rawlins and Piddini lab pinpoint role of FGFR2 in adult airway homeostasis

27.03.17 Rawlins and Piddini lab pinpoint role of FGFR2 in adult airway homeostasis

In this Development article, two collaborating research groups at the Gurdon Institute show that signalling through FGF receptor 2 is required for airway homeostasis

27.03.17 Rawlins and Piddini lab pinpoint role of FGFR2 in adult airway homeostasis - Read More…

30.03.17 Epigenetic memory of somatic cell identity inhibits reprogramming in nuclear transfer

30.03.17 Epigenetic memory of somatic cell identity inhibits reprogramming in nuclear transfer

The Gurdon lab show that genes retain a memory of their identity and active state that underlies resistance to reprogramming in nuclear transfer

30.03.17 Epigenetic memory of somatic cell identity inhibits reprogramming in nuclear transfer - Read More…

02.03.17 Identifying genes resistant to reprogramming and how epigenetic pathways are involved

02.03.17 Identifying genes resistant to reprogramming and how epigenetic pathways are involved

Performing nuclear transfer of mouse ES cells and fibroblasts allowed the Gurdon lab with international colleagues to identify genes that resist reprogramming

02.03.17 Identifying genes resistant to reprogramming and how epigenetic pathways are involved - Read More…

30.01.17 Surani lab with Institut Curie colleagues probe Xist-mediated gene silencing in early embryogenesis

30.01.17 Surani lab with Institut Curie colleagues probe Xist-mediated gene silencing in early embryogenesis

Analysing Xist-mutant embryos down to single-cell RNA sequencing, the Surani and Heard (Institut Curie) labs examine the epigenetic process of X-chromosome inactivation

30.01.17 Surani lab with Institut Curie colleagues probe Xist-mediated gene silencing in early embryogenesis - Read More…