21.09.17 Simons and Hannezo reveal a unifying theory for branching patterns in tissue
In this Cell paper, Ben Simons and Edouard Hannezo and colleagues show how the growth of ductal networks in different organs can be described by simple statistical rules
18.09.17 Building actin filaments using phosphoinositide lipids and high membrane curvature
In this JCB article the Gallop lab and colleagues use advanced fluorescence microscopy to follow the biochemistry of actin polymerisation on membranes
07.08.17 Miska lab tease out role of RNA helicase Aquarius in heritable transcriptional silencing
In this Developmental Cell paper, Akay et al. show that Aquarius/EMB-4 is a direct and essential link between small RNA pathways and the transcriptional machinery in C. elegans
05.09.17 Ufuk Günesdogan wins €1.65 M career development award
The 2017 Sofja Kovalevskaja Awards have been announced and a Gurdon Institute postdoc in the Surani lab is one of the six winners
14.08.17 New model of human lung development provided by Rawlins lab organoid system
In this eLife paper Emma Rawlins' lab, with colleagues in Cambridge and London, describe their new human lung distal tip epithelium cultures
30.08.17 Barcoding brain cancer cells helps to simplify understanding of tumour growth and treatment strategy
In this Nature article, the Simons lab and collaborators track the patterns of glioblastoma cell division and differentiation
08.08.2017 Buffering role for miR-7 in developing optic lobe
In this Cell Reports paper, Caygill and Brand present evidence that the transformation of neuroepithelial cells into neural stem cells in the developing optic lobe of the brain is buffered against environmental stress by the microRNA miR-7.
26.07.17 'Loser' cell status results from JNK JAK/STAT and oxidative stress signalling pathways
The Piddini lab pinpoint which signalling pathways are responsible for making 'loser' cells, in this Nature Communications paper
19.07.17 Huch lab wins project grant to develop patient-specific 'liver cancer organoids'
The NC3Rs has awarded a project grant to Meri Huch to explore how to grow liver cancer organoids from tumour biopsies, replacing the use of animals for such research
10.07.17 Chk1 orchestrates regulation of cell cycle length at mid-blastula transition by inhibiting Drf1
In this Dev Cell paper the Zegerman lab, with collaborator Jim Smith at the Crick, describe a role for checkpoint kinase Chk1 in the mid-blastula transition in Xenopus
31.05.17 Probing regulation of gene transcription with a computer model
Namshik Han from the Kouzarides lab, with Manchester colleagues, presents a computer model for identifying new members of transcription factor networks and new interactions between members.
07.06.17 Pinning down the origin of human primordial germ cells with the help of pig embryos
This Nature paper from the Surani lab and colleagues shows how the precursors of egg and sperm cells arise in the embryo, by using human cells in vitro and pig embryos ex vivo
06.06.17 Embryonic stem cells exhibit a spectrum of pluripotent states
The Surani lab show how embryonic stem cells can be coaxed into adopting many different pluripotent states, which influence their response to differentiation
27.04.17 Analytical chemistry reveals diversity of RNA modifications in C. elegans
The Miska lab with colleagues analyse the complete C elegans transcriptome for RNA modifications
27.04.17 Winners of our Zoom Box photo competition announced
Images taken with Zoom Boxes assembled at our Science Festival event have now been judged and prizes are on their way
07.04.17 Jackson lab use genetic suppressor screening to identify camptothecin resistance mechanism
This EMBO Report illustrates how suppressor screening can provide a rapid and effective approach to studying drug resistance mechanisms
21.03.17 Surani lab show role for maternally inherited protein, Stella
In this eLife paper, the Surani lab with EMBL colleagues show that Stella controls activation of transposable elements in the developing embryo
27.03.17 Rawlins and Piddini lab pinpoint role of FGFR2 in adult airway homeostasis
In this Development article, two collaborating research groups at the Gurdon Institute show that signalling through FGF receptor 2 is required for airway homeostasis
30.03.17 Epigenetic memory of somatic cell identity inhibits reprogramming in nuclear transfer
The Gurdon lab show that genes retain a memory of their identity and active state that underlies resistance to reprogramming in nuclear transfer
09.03.17 New cellular mechano-sensing mechanism involves E-Cadherin and actomyosin flows
Hannezo and colleagues describe in this Nature paper a new mechanism for epithelial cells to sense and transmit forces
09.03.17 Livesey lab demonstrate potential of in vitro stem cell model of dementia as drug screening platform
The Livesey lab's model of dementia in a dish, using Down syndrome patients' cells, offers a platform for screening potential drug compounds
02.03.17 Identifying genes resistant to reprogramming and how epigenetic pathways are involved
Performing nuclear transfer of mouse ES cells and fibroblasts allowed the Gurdon lab with international colleagues to identify genes that resist reprogramming
23.02.17 Andrea Brand features in Academy of Medical Sciences work-life balance campaign
#MedSciLife campaign celebrates benefits of pursuits away from the research bench
17.02.17 AstraZeneca's PARP inhibitor Lynparza shows promise for treating breast cancer
First positive randomised trial to evaluate the efficacy of a PARP inhibitor beyond ovarian cancer
30.01.17 Surani lab with Institut Curie colleagues probe Xist-mediated gene silencing in early embryogenesis
Analysing Xist-mutant embryos down to single-cell RNA sequencing, the Surani and Heard (Institut Curie) labs examine the epigenetic process of X-chromosome inactivation
30.01.17 Simons lab and colleagues identify stem cells that generate branching ducts in mammary gland
Nature paper describes how stem cell behaviour underlies branching morphogenesis in the mammary gland
25.11.16 Two Cdc20-binding sequences play key role in preventing incorrect chromatid separation
Di Fiore et al. from the Pines lab identify conserved sequence motifs that mediate inhibition of active APC/C
07.12.16 Gurdon Institute secures further five years of funding as a Wellcome Centre
Wellcome announce the renewal of the Gurdon Institute's core funding along with that of neighbouring Stem Cell Institute
25.10.16 Synthetic-lethal combination of PAXX and XLF loss in mammalian development
In this Genes & Development paper, the Jackson group and colleagues demonstrate the combined lethality of PAXX and XLF gene knockouts
13.11.16 Meri Huch wins Hamdan Award for Medical Research Excellence 2015-2016
Gurdon Institute Group Leader Meri Huch has won a prestigious prize from the Dubai-based Sheikh Hamdan bin Rashid al Maktoum Award for Medical Sciences
