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22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain

22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain

The Brand lab publish in Neural Development on the dynamic regulation of Notch signalling in the transition from optic lobe neuroepithelial cells to asymmetrically dividing neural stem cells

22.11.18 Role for Notch signalling in neural stem cell state progression in Drosophila brain - Read More…

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery

The Kouzarides and Jackson labs tease out the series of biochemical events, including a histone modification, that allows cells to recover from the DNA damage checkpoint

15.11.18 Phosphorylation of histone H4T80 triggers DNA-damage-checkpoint recovery - Read More…

26.10.18 Mapping regulatory elements across the C. elegans lifespan

26.10.18 Mapping regulatory elements across the C. elegans lifespan

The Ahringer lab and international colleagues used multiple assays to systematically identify and annotate accessible chromatin in the six C. elegans developmental stages and at five time points of adult ageing

26.10.18 Mapping regulatory elements across the C. elegans lifespan - Read More…

31.10.18 Cell polarisation of fly midgut epithelium provides better model for mammalian epithelia

The St Johnston lab's discovery of the mechanism for epithelial cell polarisation in the fly gut disproves the idea that the same conserved system establishes apical-basal polarity in all epithelia

31.10.18 Cell polarisation of fly midgut epithelium provides better model for mammalian epithelia - Read More…

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice

The Miska lab with colleagues in Switzerland show that early life trauma can cause alterations in long RNA in mouse sperm, and this contributes to transmitting the effects to the next generation

30.10.18 Long RNA species contribute to intergenerational effects of early life trauma in mice - Read More…

16.10.18 CRISPR screen identifies further genes that regulate mouse germ cell specification

16.10.18 CRISPR screen identifies further genes that regulate mouse germ cell specification

A team of current and former Surani lab researchers apply fluorescent reporters with a genome-wide CRISPR screen to track changing cellular identity in a model of developing primordial germ cells

16.10.18 CRISPR screen identifies further genes that regulate mouse germ cell specification - Read More…

11.10.18 Scientists watch development of lab-engineered human neurons transplanted into mouse brain

11.10.18 Scientists watch development of lab-engineered human neurons transplanted into mouse brain

Livesey lab and colleagues' technique for transplanting engineered human brain cells in mice, published in Science, provides insights into Down syndrome, with potential wider application

11.10.18 Scientists watch development of lab-engineered human neurons transplanted into mouse brain - Read More…

26.09.18 Role for alpha-ketoglutate in pluripotency and germ cell specification

26.09.18 Role for alpha-ketoglutate in pluripotency and germ cell specification

The Surani lab, with colleagues in Cambridge and Germany, demonstrate a link between epigenetic control of germ cell specification and the mitochondrial oxidative metabolite, alpha-ketoglutarate

26.09.18 Role for alpha-ketoglutate in pluripotency and germ cell specification - Read More…

25.09.18 The optic lobe neuroepithelium generates neural stem cells over 60 hours earlier than previously thought

25.09.18 The optic lobe neuroepithelium generates neural stem cells over 60 hours earlier than previously thought

Hakes, Otsuki and Brand show that neuroepithelial cells in the Drosophila optic lobe produce previously unidentified neural stem cells during embryonic development

25.09.18 The optic lobe neuroepithelium generates neural stem cells over 60 hours earlier than previously thought - Read More…

08.09.18 Branching gene expression in response to infection analysed with Gaussian processes

08.09.18 Branching gene expression in response to infection analysed with Gaussian processes

Penfold et al from the Surani lab apply statistical methods to understand patterns in changes in gene expression following perturbations such as infection

08.09.18 Branching gene expression in response to infection analysed with Gaussian processes - Read More…

10.09.18 New technique reveals how Zika interacts inside cells and could enable new anti-viral therapies

The COMRADES technique, developed by the Miska lab with international colleagues, can screen for host–virus RNA base-pairing and reveal the interacting sequences of RNA in a single experiment. In this Nature Methods paper they apply it to the Zika virus in human cells.

10.09.18 New technique reveals how Zika interacts inside cells and could enable new anti-viral therapies - Read More…

13.08.18 Antiviral gene screen in C elegans reveals third mechanism for antiviral defence

13.08.18 Antiviral gene screen in C elegans reveals third mechanism for antiviral defence

The Miska lab, with UK and USA collaborators, developed a system for antiviral gene discovery and identified 3'-terminal uridylation of viral RNAs as a defence mechanism in animals

13.08.18 Antiviral gene screen in C elegans reveals third mechanism for antiviral defence - Read More…

21.06.18 RNA helicase DDX3X is indirect regulator of breast cancer cell cycle

21.06.18 RNA helicase DDX3X is indirect regulator of breast cancer cell cycle

The Kouzarides lab identify how DDX3X plays oncogenic role in breast cancer cells via effect on expression and downstream function of KLF4

21.06.18 RNA helicase DDX3X is indirect regulator of breast cancer cell cycle - Read More…

18.08.18 Resolving the cellular basis of mouse pancreas development

18.08.18 Resolving the cellular basis of mouse pancreas development

The Simons and Huch labs, with Cambridge Stem Cell Institute colleagues, tease out the cellular mechanisms by which the pancreas develops its branched ductal structures

18.08.18 Resolving the cellular basis of mouse pancreas development - Read More…

10.07.18 Chromatin accessibility is a central factor in successful reprogramming in oocytes

10.07.18 Chromatin accessibility is a central factor in successful reprogramming in oocytes

In this Cell Reports article the Gurdon and Livesey labs show an association between the local chromatin state and whether genes are activated by or resistant to reprogramming

10.07.18 Chromatin accessibility is a central factor in successful reprogramming in oocytes - Read More…

18.07.18 'Shieldin' protein complex identified that affects response of BRCA1-negative cells to PARP inhibitors

The Jackson lab, with an international team of collaborators, show that testing for levels of the Shieldin complex in BRCA1 mutant tumours could help predict response to anti-cancer therapy

18.07.18 'Shieldin' protein complex identified that affects response of BRCA1-negative cells to PARP inhibitors - Read More…

18.07.18 Genome-scale oscillations in DNA methylation as cells undergo fate decisions

18.07.18 Genome-scale oscillations in DNA methylation as cells undergo fate decisions

The Simons lab with colleagues from the Babraham Institute combined single-cell sequencing and biophysical modelling to follow DNA methylation states as cells begin to differentiate

18.07.18 Genome-scale oscillations in DNA methylation as cells undergo fate decisions - Read More…

03.07.18 Identifying and targeting a nuclear transport pathway affected in premature and healthy ageing

03.07.18 Identifying and targeting a nuclear transport pathway affected in premature and healthy ageing

The Jackson and Kouzarides labs present a model for how NAT10 inhibition rescues cells with phenotypes of the premature ageing disease Hutchinson-Gilford progeria syndrome

03.07.18 Identifying and targeting a nuclear transport pathway affected in premature and healthy ageing - Read More…

26.06.18 New method for sequencing cell type-specific transcriptomes without cell sorting

26.06.18 New method for sequencing cell type-specific transcriptomes without cell sorting

In this Development report, Matsushima et al. present their new technique based on using a cell-specific promoter for in vivo metabolic RNA sequencing without cell sorting or RNA isolation

26.06.18 New method for sequencing cell type-specific transcriptomes without cell sorting - Read More…

19.06.18 RNA-binding protein SRSF3 shown to regulate the maternal transcriptome in mouse oocyte

19.06.18 RNA-binding protein SRSF3 shown to regulate the maternal transcriptome in mouse oocyte

The Surani lab, with colleagues in Cambridge, Norwich, London and Singapore, highlight the role of RNA-binding proteins in controlling the maternal transcriptome for correct development of fertilised oocytes

19.06.18 RNA-binding protein SRSF3 shown to regulate the maternal transcriptome in mouse oocyte - Read More…

10.05.18 Surani lab show epigenetic modifier G9a is vital in preimplanation embryo development

10.05.18 Surani lab show epigenetic modifier G9a is vital in preimplanation embryo development

In this eLife paper the Surani lab examine effects of loss of maternally inherited G9a on regulation of cell fate choices at onset of embryo development

10.05.18 Surani lab show epigenetic modifier G9a is vital in preimplanation embryo development - Read More…

27.04.18 Mouse study identifies new target for increasing health and lifespan in a human accelerated ageing syndrome

27.04.18 Mouse study identifies new target for increasing health and lifespan in a human accelerated ageing syndrome

The Jackson lab, working with colleagues at Wellcome Sanger Institute, have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome

27.04.18 Mouse study identifies new target for increasing health and lifespan in a human accelerated ageing syndrome - Read More…

27.03.18 Ben Simons awarded Royal Society EP Abraham Research Professorship

27.03.18 Ben Simons awarded Royal Society EP Abraham Research Professorship

In March the Royal Society announced the latest awards of coveted professorships to six world-class scientists, with Ben Simons of the Gurdon Institute among them

27.03.18 Ben Simons awarded Royal Society EP Abraham Research Professorship - Read More…

18.04.18 Jackson lab establishes method to detect spontaneous or chemically-induced suppressor mutations

18.04.18 Jackson lab establishes method to detect spontaneous or chemically-induced suppressor mutations

In this Scientific Report, Herzog et al. of the Jackson lab demonstrate a method of detecting functional protein domains that can be used to identify drug targets and predict resistance mechanisms

18.04.18 Jackson lab establishes method to detect spontaneous or chemically-induced suppressor mutations - Read More…

24.04.18 Invitation to our special event at Kettle's Yard on 12th May 2018

24.04.18 Invitation to our special event at Kettle's Yard on 12th May 2018

Come along to hear from the artists and scientists involved in our collaborative project, 'Experiments in Art and Science'

24.04.18 Invitation to our special event at Kettle's Yard on 12th May 2018 - Read More…

16.04.18 Rawlins lab identify two genes required for regulation of multiciliated cell differentiation

16.04.18 Rawlins lab identify two genes required for regulation of multiciliated cell differentiation

In this Biology Open paper, Johnson et al. developed an in vitro explant assay of embryonic mouse trachea to test over-expression of genes from multiciliated cells

16.04.18 Rawlins lab identify two genes required for regulation of multiciliated cell differentiation - Read More…

05.04.18 Otsuki and Brand identify new stem cells that could aid regenerative medicine for brain repair

05.04.18 Otsuki and Brand identify new stem cells that could aid regenerative medicine for brain repair

In this paper in Science, Otsuki and Brand report the discovery in the brain of a new type of quiescent stem cell (known as ‘G2 quiescent stem cell’) with higher regenerative potential than quiescent stem cells identified previously

05.04.18 Otsuki and Brand identify new stem cells that could aid regenerative medicine for brain repair - Read More…

29.03.18 In vitro model of human microglia derived from patient's stem cells developed in Livesey lab

29.03.18 In vitro model of human microglia derived from patient's stem cells developed in Livesey lab

This stem cell model of microglia, the brain’s macrophages, enabled the Livesey lab to examine the effects of mutations in the TREM2 receptor, which are causative for dementia

29.03.18 In vitro model of human microglia derived from patient's stem cells developed in Livesey lab - Read More…

27.03.18 Livesey lab show that neurons take up single and aggregated tau molecules by two mechanisms

27.03.18 Livesey lab show that neurons take up single and aggregated tau molecules by two mechanisms

The transfer of aggregated tau between neurons was proposed to underlie the spread of pathology in dementia, but the Livesey lab show that neurons in vitro take up extracellular tau using endocytosis and micropinocytosis

27.03.18 Livesey lab show that neurons take up single and aggregated tau molecules by two mechanisms - Read More…