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Read more at: 30.06.21 Identification of new drugs that could be repurposed against COVID-19
Drug repurposing for COVID-19  infographic for Han et al paper

30.06.21 Identification of new drugs that could be repurposed against COVID-19

30 June 2021

Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies Han N et al. (2021) Science Advances Vol. 7, no. 27, eabh3032. DOI: 10.1126/sciadv.abh3032. Read the press release from the University of Cambridge Abstract from the paper The global outbreak of severe acute respiratory syndrome coronavirus 2...


Read more at: 02.06.21. Mutant intestinal epithelial cells create an environment that allows tumour cells to flourish at the expense of neighbours
Images showing intestinal cells labelled with multiple colours

02.06.21. Mutant intestinal epithelial cells create an environment that allows tumour cells to flourish at the expense of neighbours

1 June 2021

Min Kyu Yum, Seungmin Han and colleagues from the Simons lab, together with collaborators in Vienna, have discovered that mutant intestinal epithelial cells remodel their environment to gain competitive advantage, providing a first step in cancer initiation. Tracing oncogene-driven remodeling of the intestinal stem cell...


Read more at: 26.05.21 New guidelines open up possibilities for studying the earliest stages of human development
Schematic of human and mouse early embryo development

26.05.21 New guidelines open up possibilities for studying the earliest stages of human development

27 May 2021

Azim Surani is a member of an international team of experts who have prepared new guidelines for research on human development, issued by the International Society for Stem Cell Research (ISSCR) in response to rapid progress and technical developments in this field. Azim is also a co-author of two papers explaining the new...


Read more at: 26.05.21 STED imaging of microtubules by St Johnston lab helps identify target for new inotropic therapies
Super-resolution microscopy images of microtubules in heart cells

26.05.21 STED imaging of microtubules by St Johnston lab helps identify target for new inotropic therapies

25 May 2021

The STED imaging system built by Allgeyer and Sirinakis at the Gurdon Institute has proved crucial in a research collaboration to understand why heart muscle weakens after a heart attack. By visualising microtubules in cardiac cells, the St Johnston lab researchers helped an international team to identify a new target for...


Read more at: 05.05.21 Kouzarides lab show that histone modification by Set1 and Set2 regulates DNA replication origin licensing
Graphic illustrates result on DNA replication of loss of HK37me1

05.05.21 Kouzarides lab show that histone modification by Set1 and Set2 regulates DNA replication origin licensing

19 May 2021

The Kouzarides lab find that two enzymes, Set1 and Set2, are responsible for methylation of H3K37, which protects the genome from inappropriate origin licensing and spurious DNA replication. Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication Santos-Rosa H et al . (2021) Molecular Cell...


Read more at: 13.05.21 Gurdon and Simons labs show that secreted inhibitors drive the loss of limb regeneration competence
Schematic of factors in regeneration competent and incompetent limb

13.05.21 Gurdon and Simons labs show that secreted inhibitors drive the loss of limb regeneration competence

19 May 2021

Research by Can Aztekin with the Gurdon and Simons labs has provided new insight into why the innate regenerative capacity of Xenopus laevis tadpole limbs becomes suppressed during later stages of development. Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs Aztekin C et al. (2021) Development...


Read more at: 22.02.21 Brand lab and colleagues identify novel role for Perlecan in organisation and maintenance of germline stem cell niche
Figure from Brand paper about Perlecan in stem cell niche

22.02.21 Brand lab and colleagues identify novel role for Perlecan in organisation and maintenance of germline stem cell niche

12 May 2021

A collaboration between the Brand lab and former St. Johnston lab member, Acaimo Gonzalez Reyes, has identified a novel function for the evolutionarily conserved extracellular matrix component, Perlecan, in maintaining germline stem cell populations Stem cell niche organization in the Drosophila ovary requires the ECM...


Read more at: 12.05.21 Ben Simons elected Fellow of the Academy of Medical Sciences
Prof Ben Simons portrait

12.05.21 Ben Simons elected Fellow of the Academy of Medical Sciences

12 May 2021

Gurdon Institute Senior Group Leader and Royal Society E.P. Abraham Professor, Ben Simons, is among 50 prominent biomedical and health scientists who have joined the Fellowship of the Academy of Medical Sciences. The Academy of Medical Sciences is an independent body in the UK representing the diversity of medical science...


Read more at: 10.05.21 Simons lab in interdisciplinary collaboration show mechanical influence on epithelial cell fate
Schematic of experiments by McGinn et al on oesophageal epithelium

10.05.21 Simons lab in interdisciplinary collaboration show mechanical influence on epithelial cell fate

12 May 2021

A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium McGinn J et al. (2021) Nature Cell Biology DOI: 10.1038/s41556-021-00679-w. In an interdisciplinary collaboration with the Alcolea lab at the Wellcome-MRC Cambridge Stem Cell Institute, the Simons lab shows that physiological...


Read more at: 06.05.21 Professors Julie Ahringer and Ben Simons elected as Fellows of the Royal Society
Ben Simons and Julie Ahringer

06.05.21 Professors Julie Ahringer and Ben Simons elected as Fellows of the Royal Society

5 May 2021

The Gurdon Institute is proud to announce that two group leaders have today been elected as Fellows of the Royal Society. Professor Julie Ahringer Julie Ahringer (above right) has made wide-ranging contributions to molecular genetics through her work on the nematode C. elegans . She carried out the first systematic...