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29.11.19 Role for the integrin Myospheroid in defining egg chamber architecture in Drosophila

29.11.19 Role for the integrin Myospheroid in defining egg chamber architecture in Drosophila

Integrins are proteins that link cells and tissues to their underlying substrate. New research from the St Johnston lab shows how these proteins help to define the architecture of the Drosophila egg chamber, a model for organ development.

29.11.19 Role for the integrin Myospheroid in defining egg chamber architecture in Drosophila - Read More…

27.11.19 Gene discovery in fruit flies could help guide new treatments for mitochondrial disease

27.11.19 Gene discovery in fruit flies could help guide new treatments for mitochondrial disease

The Ma lab have identified several nuclear genes in fruit flies that influence mitochondrial DNA transmission, providing potential leads for drug discovery to treat human mitochondrial diseases

27.11.19 Gene discovery in fruit flies could help guide new treatments for mitochondrial disease - Read More…

15.11.19 MDC1 retains capacity to recruit repair factors to sites of DNA damage in absence of H2AX

15.11.19 MDC1 retains capacity to recruit repair factors to sites of DNA damage in absence of H2AX

Salguero et al. from Steve Jackson's lab show that DNA-damage response protein MDC1 unexpectedly retains its capacity to recruit repair factors to sites of damage in the absence of H2AX. This represents an alternative pathway to promote DNA repair.

15.11.19 MDC1 retains capacity to recruit repair factors to sites of DNA damage in absence of H2AX - Read More…

16.09.19 Discovery of first selective inhibitors of the Fanconi anaemia pathway that mediates chemotherapy resistance

Galanty and colleagues in the Jackson lab identify two small-molecule inhibitors of the Fanconi anemia pathway, necessary for cancer cells that are - or become - resistant to DNA cross-linking therapeutics. These provide leads for development of drugs to re-sensitise tumours to cross-linking agents such as cisplatin.

16.09.19 Discovery of first selective inhibitors of the Fanconi anaemia pathway that mediates chemotherapy resistance - Read More…

01.11.19 Checkpoint inhibition of origin firing prevents DNA topological stress

01.11.19 Checkpoint inhibition of origin firing prevents DNA topological stress

Morafraile et al. from the Zegerman lab with UK colleagues reveal that the role of limiting the number of DNA replication initiation events is to prevent DNA topological stress, which may be relevant for cancer treatment with both topoisomerase and checkpoint inhibitors.

01.11.19 Checkpoint inhibition of origin firing prevents DNA topological stress - Read More…

04.11.19 Regeneration mechanism uncovered in adult mouse liver tissue provides target for drug design

The Huch lab and collaborators have uncovered a novel molecular mechanism in mice that allows damaged adult liver cells to regenerate, paving the way for design of drugs to boost regeneration in conditions such as cirrhosis or other chronic liver diseases where regeneration is impaired.

04.11.19 Regeneration mechanism uncovered in adult mouse liver tissue provides target for drug design - Read More…

11.10.19 ERC Synergy Grant for Jackson lab in European collaborative project on DNA damage response

Steve Jackson's lab is the first in Cambridge to be awarded a new European Research Council Synergy Grant under the Horizon 2020 funding programme from the European Union. Steve's research collaborators are in Switzerland and Austria.

11.10.19 ERC Synergy Grant for Jackson lab in European collaborative project on DNA damage response - Read More…

09.10.19 Rawlins lab researchers are captured in oils for The Rising Tide exhibition at UL

Artist Caroline Walker watched and photographed researchers at the bench in the Rawlins lab at the Gurdon Institute and created a stunning, large-format oil painting for the University Library's upcoming exhibition, 'The Rising Tide: Women at Cambridge'.

09.10.19 Rawlins lab researchers are captured in oils for The Rising Tide exhibition at UL - Read More…

12.09.19 Blocking mitochondria-generated energy reduces brain tumour growth and stem cell differentiation

12.09.19 Blocking mitochondria-generated energy reduces brain tumour growth and stem cell differentiation

Jelle van den Ameele and Andrea Brand studied mitochondrial metabolism in normal brain development and in brain tumours in the fruit fly, showing that it contributes to stem cell differentiation as well as cell proliferation

12.09.19 Blocking mitochondria-generated energy reduces brain tumour growth and stem cell differentiation - Read More…

26.09.19 Meri Huch receives BINDER Innovation Prize 2019 from German Society for Cell Biology

The annual prize, founded by German company BINDER GmbH, is awarded for outstanding cell biological research with a focus on cell culture or the use of cell cultures

26.09.19 Meri Huch receives BINDER Innovation Prize 2019 from German Society for Cell Biology - Read More…

11.09.19 'Herculean' project catalogues over 4,500 mutational signatures of the Yeast Knockout Collection

11.09.19 'Herculean' project catalogues over 4,500 mutational signatures of the Yeast Knockout Collection

Jackson lab researchers create unique genomics resource from > 4,500 yeast strains to identify genes protecting cells from DNA alterations that are implicated in human disease and ageing

11.09.19 'Herculean' project catalogues over 4,500 mutational signatures of the Yeast Knockout Collection - Read More…

15.08.19 Defining two populations of stem cells in the gastric corpus epithelium

15.08.19 Defining two populations of stem cells in the gastric corpus epithelium

Simons, Koo and colleagues define the identity and dynamics of adult gastric isthmus stem cells, which maintain the rapid turnover of the upper part of the corpus gland

15.08.19 Defining two populations of stem cells in the gastric corpus epithelium - Read More…

29.07.19 Revealing the cellular mechanism of sebaceous gland development in mouse

29.07.19 Revealing the cellular mechanism of sebaceous gland development in mouse

Ben Simons and collaborators in Copenhagen and Vienna probe the origin, development and maintenance of the sebaceous gland in mouse skin, using clonal fate studies.

29.07.19 Revealing the cellular mechanism of sebaceous gland development in mouse - Read More…

21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance

21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance

This study from the Miska lab, with colleagues at Imperial, provides a first reference of house sparrow sperm small RNA as an attempt to uncover their role in the transmission of the effects of paternal age on the offspring.

21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance - Read More…

27.04.19 Discovering gene circuits using machine-learning algorithms

27.04.19 Discovering gene circuits using machine-learning algorithms

Tom Hiscock in the Simons group applied a computational approach to generate algorithms describing natural gene circuits and for designing circuits in synthetic biology. The work is published in BMC Bioinformatics

27.04.19 Discovering gene circuits using machine-learning algorithms - Read More…

29.05.19 Bipotent stem cells in embryonic liver give rise to hepatocytes and cholangiocytes

Prior et al. in the Huch and Simons labs use lineage tracing, sc-RNA seq and organoid culture to show that Lgr5 is a marker for a sub-population of bipotent liver progenitor cells

29.05.19 Bipotent stem cells in embryonic liver give rise to hepatocytes and cholangiocytes - Read More…

06.10.18 International honour for Tony Kouzarides from learned society in the USA

Senior group leader Prof Tony Kouzarides has been elected an International Honorary Member of the American Academy of Arts and Sciences.

06.10.18 International honour for Tony Kouzarides from learned society in the USA - Read More…

02.04.19 Citrullination of heterochromatin protein 1 gamma diminishes when stem cells differentiate

02.04.19 Citrullination of heterochromatin protein 1 gamma diminishes when stem cells differentiate

The Kouzarides lab and colleagues identify citrullination of HP1γ within its chromodomain as a novel post-translational modification in mouse embryonic stem cells (mESCs) that is dynamically regulated during mESC differentiation.

02.04.19 Citrullination of heterochromatin protein 1 gamma diminishes when stem cells differentiate - Read More…

02.05.19 Transmissible RNA pathway in honey bees offers potential route for bee 'vaccines'

Eyal Maori with the Miska lab and collaborators in Israel, the USA and UK show that honey bees share genetic material via their equivalent of mother's milk, allowing spread between colony members. In addition, the scientists identify the chemical composition of an RNA-stabilising protein in royal jelly that protects the RNA when outside the body

02.05.19 Transmissible RNA pathway in honey bees offers potential route for bee 'vaccines' - Read More…

25.04.19  m7G is a new RNA-modification pathway with phenotypic effects

25.04.19 m7G is a new RNA-modification pathway with phenotypic effects

The Kouzarides lab identify a METTL1-dependent modification of RNA, N7-methylation of guanosine, as a new modification pathway regulating miRNA structure and biogenesis, with a phenotypic effect on cancer cell migration

25.04.19 m7G is a new RNA-modification pathway with phenotypic effects - Read More…

06.04.19 Ten years since first ever single-cell RNA seq paper - from the Gurdon Institute

06.04.19 Ten years since first ever single-cell RNA seq paper - from the Gurdon Institute

The technique for examining all the gene products in one cell at one timepoint, single-cell RNA sequencing, was established right here at the Gurdon Institute in Azim Surani's lab. The method was published on 6 April 2009; below is the abstract and a recent paper analysing successive developments in the technique.

06.04.19 Ten years since first ever single-cell RNA seq paper - from the Gurdon Institute - Read More…

26.03.19 Identifying locations and homogeneity of N-6 methylated deoxyadenosine

26.03.19 Identifying locations and homogeneity of N-6 methylated deoxyadenosine

Pacini et al. from the Gurdon lab have mapped the novel DNA modification m6dA at nucleotiode level in the human genome, showing that this low-abundance mark occurs precisely and consistently

26.03.19 Identifying locations and homogeneity of N-6 methylated deoxyadenosine - Read More…

21.03.19 Neural stem cell activation speed depends on position in brain

21.03.19 Neural stem cell activation speed depends on position in brain

Otsuki and Brand show that in the Drosophila brain, the speed at which stem cells can be activated to start diving depends on their dorsal-ventral location, an important consideration in designing regeneration therapies

21.03.19 Neural stem cell activation speed depends on position in brain - Read More…

18.02.19 Miska lab identify hundreds of new non-coding RNAs and prove biological activity in several

C elegans is the model of choice for identifying long non-coding RNAs and investigating whether their deletion has biological effects. The Miska lab, with the Earlham Institute, find several that affect growth and fertility.

18.02.19 Miska lab identify hundreds of new non-coding RNAs and prove biological activity in several - Read More…

28.02.19 Extending Turing's reaction-diffusion model with mechanics, for robust tissue patterning during development

28.02.19 Extending Turing's reaction-diffusion model with mechanics, for robust tissue patterning during development

The Simons lab, with colleagues in France and Austria, devise a new model for tissue patterning, proposing that mechanical forces work in combination with chemical gradients to generate spatial patterns

28.02.19 Extending Turing's reaction-diffusion model with mechanics, for robust tissue patterning during development - Read More…

21.02.19 Miska lab find sex differences in gene silencing by environmental RNA

21.02.19 Miska lab find sex differences in gene silencing by environmental RNA

Using C elegans as a model, the Miska lab and colleagues show clear differences between sexes in small RNA abundance that are associated with trans-generational inheritance

21.02.19 Miska lab find sex differences in gene silencing by environmental RNA - Read More…

22.02.19 Physical and molecular underpinnings of proneural wave in Drosophila optic lobe

22.02.19 Physical and molecular underpinnings of proneural wave in Drosophila optic lobe

The Simons and Brand labs combine expertise to show that a reaction-diffusion mechanism underlies a travelling wave of gene expression that turns neuroepithelial cells into neuroblasts

22.02.19 Physical and molecular underpinnings of proneural wave in Drosophila optic lobe - Read More…