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News from the Gurdon Institute
16.04.18 Rawlins lab identify two genes required for regulation of multiciliated cell differentiation

16.04.18 Rawlins lab identify two genes required for regulation of multiciliated cell differentiation

In this Biology Open paper, Johnson et al. developed an in vitro explant assay of embryonic mouse trachea to test over-expression of genes from multiciliated cells

16.04.18 Rawlins lab identify two genes required for regulation of multiciliated cell differentiation - Read More…

05.04.18 Otsuki and Brand identify new stem cells that could aid regenerative medicine for brain repair

05.04.18 Otsuki and Brand identify new stem cells that could aid regenerative medicine for brain repair

In this paper in Science, Otsuki and Brand report the discovery in the brain of a new type of quiescent stem cell (known as ‘G2 quiescent stem cell’) with higher regenerative potential than quiescent stem cells identified previously

05.04.18 Otsuki and Brand identify new stem cells that could aid regenerative medicine for brain repair - Read More…

29.03.18 In vitro model of human microglia derived from patient's stem cells developed in Livesey lab

29.03.18 In vitro model of human microglia derived from patient's stem cells developed in Livesey lab

This stem cell model of microglia, the brain’s macrophages, enabled the Livesey lab to examine the effects of mutations in the TREM2 receptor, which are causative for dementia

29.03.18 In vitro model of human microglia derived from patient's stem cells developed in Livesey lab - Read More…

27.03.18 Livesey lab show that neurons take up single and aggregated tau molecules by two mechanisms

27.03.18 Livesey lab show that neurons take up single and aggregated tau molecules by two mechanisms

The transfer of aggregated tau between neurons was proposed to underlie the spread of pathology in dementia, but the Livesey lab show that neurons in vitro take up extracellular tau using endocytosis and micropinocytosis

27.03.18 Livesey lab show that neurons take up single and aggregated tau molecules by two mechanisms - Read More…

27.03.18 Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting

27.03.18 Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting

Azim Surani of the Gurdon Institute and Davor Solter of the Max Planck Institute of Immunobiology and Epigenetics will receive Canada's top research award from the Gairdner Foundation in recognition of their work establishing the field of epigenetics with the discovery of genomic imprinting

27.03.18 Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting - Read More…

15.03.18 Using positional information to identify functions of long non-coding RNAs

15.03.18 Using positional information to identify functions of long non-coding RNAs

The Kouzarides lab used a bioinformatics approach to identify hundreds of lncRNAs physically and functionally connected to developmental transcription sites

15.03.18 Using positional information to identify functions of long non-coding RNAs - Read More…

14.03.18 Invitation to a special seminar by Julie Ahringer, Gurdon Institute

Join us to hear Julie Ahringer, Professor of Genetics and Genomics at the Gurdon Institute, describe her research on in vivo mechanisms that control chromatin architecture and gene expression in development

14.03.18 Invitation to a special seminar by Julie Ahringer, Gurdon Institute - Read More…

02.03.18 Invitation to a special seminar by Rama Khokha, University of Toronto

Come and hear Rama Khokha talk about her research on tissue homeostasis and its disintegration in cancer and disease

02.03.18 Invitation to a special seminar by Rama Khokha, University of Toronto - Read More…

08.02.18 Two projects on the CRUK Grand Challenge shortlist feature Gurdon Institute scientists

08.02.18 Two projects on the CRUK Grand Challenge shortlist feature Gurdon Institute scientists

Gurdon Institute researchers are part of two international teams whose projects have been selected onto the shortlist for CRUK's biggest research grants of £20 million, the 'Grand Challenge'

08.02.18 Two projects on the CRUK Grand Challenge shortlist feature Gurdon Institute scientists - Read More…

15.01.18 Insights into why mitochondrial diseases can strike previously unaffected families

15.01.18 Insights into why mitochondrial diseases can strike previously unaffected families

The Surani lab with Patrick Chinnery and colleagues show in this Nature Cell Biology paper that egg precursor cells from healthy females harbour a small number of defects in mitochondrial DNA, that could lead to incurable disease

15.01.18 Insights into why mitochondrial diseases can strike previously unaffected families - Read More…

04.01.18 Glial cells create adaptive niche for neural stem cell lineages in Drosophila brain

04.01.18 Glial cells create adaptive niche for neural stem cell lineages in Drosophila brain

In this Elife paper, Speder & Brand show how both nutritional and local cues stimulate cortex glial cells to create a membrane sheath around each proliferating neural stem cell lineage

04.01.18 Glial cells create adaptive niche for neural stem cell lineages in Drosophila brain - Read More…

18.12.17 Novel method for detecting cell-type-specific lncRNA-genome interactions

18.12.17 Novel method for detecting cell-type-specific lncRNA-genome interactions

In this Nature Structural and Molecular Biology article, Cheetham and Brand demonstrate an effective technique to examine the role of lncRNA-chromatin interactions

18.12.17 Novel method for detecting cell-type-specific lncRNA-genome interactions - Read More…

12.12.17 And the 2018 Women in Cell Biology Early Career Medal goes to...Meritxell Huch

12.12.17 And the 2018 Women in Cell Biology Early Career Medal goes to...Meritxell Huch

Awarded by the British Society for Cell Biology, the annual Women in Cell Biology Medal honours the most promising early career female researchers, to serve as inspiring role models for the next generation

12.12.17 And the 2018 Women in Cell Biology Early Career Medal goes to...Meritxell Huch - Read More…

12.11.17 Cancer theory revisited and debated at interdisciplinary workshop in Austria

12.11.17 Cancer theory revisited and debated at interdisciplinary workshop in Austria

A 'revised theory of cancer' was discussed at an international workshop in Austria by a high-profile group of cancer cell biologists, clinicians and data scientists to assess the need for a new theoretical paradigm in cancer research

12.11.17 Cancer theory revisited and debated at interdisciplinary workshop in Austria - Read More…

27.11.17 METTL3 is an unforeseen new drug target for Acute Myeloid Leukaemia

27.11.17 METTL3 is an unforeseen new drug target for Acute Myeloid Leukaemia

The Kouzarides lab and colleagues, in this Nature paper, describe their discovery of a specific drug target for acute myeloid leukaemia

27.11.17 METTL3 is an unforeseen new drug target for Acute Myeloid Leukaemia - Read More…

27.10.17 Surani lab and colleagues derive 'advanced' pluripotent stem cells

27.10.17 Surani lab and colleagues derive 'advanced' pluripotent stem cells

In this Cell Research paper the Surani lab describe cells, derived from blastocysts, that exhibit an intermediate potency state between pre- and post-implantation stem cells

27.10.17 Surani lab and colleagues derive 'advanced' pluripotent stem cells - Read More…

26.10.17 Cyclin B1's essential role in mitosis and the timing of entry into mitosis

26.10.17 Cyclin B1's essential role in mitosis and the timing of entry into mitosis

Bernhard Strauss of the former Pines lab and collegues show in this J Cell Biol paper that Cyclin B1 is required for cell division in mouse embryos

26.10.17 Cyclin B1's essential role in mitosis and the timing of entry into mitosis - Read More…

16.10.17 Role for dynactin in protecting microtubules to deliver oskar mRNA to the oocyte posterior

16.10.17 Role for dynactin in protecting microtubules to deliver oskar mRNA to the oocyte posterior

In this eLife paper the St Johnston lab with Cambridge colleagues describe a role for dynactin as an 'anti-catastrophe' factor in oocyte polarisation

16.10.17 Role for dynactin in protecting microtubules to deliver oskar mRNA to the oocyte posterior - Read More…

03.11.17 X-chromosome reactivation in the inner cell mass happens at different stages for different genes

03.11.17 X-chromosome reactivation in the inner cell mass happens at different stages for different genes

Borensztein et al. show in this Nature Communications paper that different genes on the paternal X-chromosome may be reactivated by transcription factors or active erasure of chromatin marks

03.11.17 X-chromosome reactivation in the inner cell mass happens at different stages for different genes - Read More…

21.09.17 Simons and Hannezo reveal a unifying theory for branching patterns in tissue

21.09.17 Simons and Hannezo reveal a unifying theory for branching patterns in tissue

In this Cell paper, Ben Simons and Edouard Hannezo and colleagues show how the growth of ductal networks in different organs can be described by simple statistical rules

21.09.17 Simons and Hannezo reveal a unifying theory for branching patterns in tissue - Read More…

18.09.17 Building actin filaments using phosphoinositide lipids and high membrane curvature

18.09.17 Building actin filaments using phosphoinositide lipids and high membrane curvature

In this JCB article the Gallop lab and colleagues use advanced fluorescence microscopy to follow the biochemistry of actin polymerisation on membranes

18.09.17 Building actin filaments using phosphoinositide lipids and high membrane curvature - Read More…

07.08.17 Miska lab tease out role of RNA helicase Aquarius in heritable transcriptional silencing

07.08.17 Miska lab tease out role of RNA helicase Aquarius in heritable transcriptional silencing

In this Developmental Cell paper, Akay et al. show that Aquarius/EMB-4 is a direct and essential link between small RNA pathways and the transcriptional machinery in C. elegans

07.08.17 Miska lab tease out role of RNA helicase Aquarius in heritable transcriptional silencing - Read More…