12.06.20 Transcription factor Ascl1's long residency on chromatin is likely to stabilise cell fate commitment
John Gurdon's group used a binding competition assay to show that the nerve cell determinant Ascl1 has a long-term association with its chromatin binding site, stabilising gene expression and cell fate commitment
23.05.20 Assessing the impact of cellular p53 status on CRISPR-Cas9 screen performance
In this Elife paper, the Jackson lab show functional p53 status negatively affects identification of significantly depleted genes in a CRISPR-Cas9 screen in human RPE cells, and suggest how to optimise screen design to overcome this
08.04.20 Miska lab probe mechanism of a heritable adaptation to infection in C. elegans
In this Nat Comms study using nematode worms, the Miska lab and collaborators show that parental exposure to a pathogen can increase the future offspring's resistance to infection, in a process mediated by two cysteine synthase enzymes.
25.03.20 Gallop lab use antibody technology to identify role for SNX9 in filopodia
Conducting a phenotypic screen by phage display, Jarsch, Gadsby and colleagues use antibodies to identify the actin regulator SNX9 as an essential component of filopodia-like structures in vitro and its localisation to filopodia in human cells
19.02.20 Brand lab use lineage tracing to identify brain tumour cell of origin
In their new study, Hakes and Brand show that high levels of Tailless/TLX drive tumour initiation by reverting intermediate progenitors to neural stem cells. In addition to identifying the cell fate changes that occur upon high expression of Tailless/TLX, they were able to prevent tumour formation and restore neurogenesis by re-expressing the proneural gene asense/ASCL1. Their results potentially implicate intermediate progenitors as one of the cells of origin in TLX-positive glioblastomas, an aggressive and lethal brain tumour.
03.03.2020 A dot-stripe mechanism proposed for joint patterning provides new unifying theory
Cornwall Scoones and Hiscock propose a dot-stripe Turing mechanism that can account for joint patterns in creatures ranging from extinct reptiles and whale fins to mammalian paws, providing a unifying framework to study joint development
09.03.20 PRDM14 activity in human primordial germ cells differs from development in mouse
Sybirna et al. in the Surani lab reveal the role of PRDM14 in human germ cell differentiation using special method for specific and rapid depletion of protein as cells develop in vitro
26.02.20 Pancreas organoids pave the way for researching diabetes, cancer and cystic fibrosis
The Huch lab and collaborators share their system for growing and maintaining pancreas organoids in culture, providing an abundant source of pancreas ductal cells that retain the characteristics of the tissue-of-origin
10.02.20 Role of the protein PALB2 in the DNA-damage response
The Jackson lab are piecing together the puzzle of how cancer cells become resistant to the PARP inhibitors designed to target BRCA1/2 deficient cells. They describe the role of PALB2 in protein interactions that form the DNA damage response
10.02.20 Jackson lab show that chronic irradiation induces histone loss in human cells
The Jackson lab, in collaboration with Public Health England, have shown that histones are lost in human cells when DNA damage is continually inflicted by exposure to low levels of chronic radiation. They show that this has effects on chromatin and cellular responses that could lead to age-related diseases.
27.01.20 Gurdon lab reveal the interaction between immune response and regeneration in tadpoles
Can Aztekin of the Gurdon lab and colleagues identify the cells of the immune response that are involved in creating the conditions for regeneration in the tadpole
29.01.20 Julie Ahringer honoured with the Beadle Award from the Genetics Society of America
The GSA today announced the 2020 recipients of its annual awards for distinguished service in the field of genetics. Gurdon Institute Director Julie Ahringer receives the George W. Beadle Award for outstanding contributions to the community of genetics researchers.
29.11.19 Role for the integrin Myospheroid in defining egg chamber architecture in Drosophila
Integrins are proteins that link cells and tissues to their underlying substrate. New research from the St Johnston lab shows how these proteins help to define the architecture of the Drosophila egg chamber, a model for organ development.
27.11.19 Gene discovery in fruit flies could help guide new treatments for mitochondrial disease
The Ma lab have identified several nuclear genes in fruit flies that influence mitochondrial DNA transmission, providing potential leads for drug discovery to treat human mitochondrial diseases
15.11.19 MDC1 retains capacity to recruit repair factors to sites of DNA damage in absence of H2AX
Salguero et al. from Steve Jackson's lab show that DNA-damage response protein MDC1 unexpectedly retains its capacity to recruit repair factors to sites of damage in the absence of H2AX. This represents an alternative pathway to promote DNA repair.
16.09.19 Discovery of first selective inhibitors of the Fanconi anaemia pathway that mediates chemotherapy resistance
Galanty and colleagues in the Jackson lab identify two small-molecule inhibitors of the Fanconi anemia pathway, necessary for cancer cells that are - or become - resistant to DNA cross-linking therapeutics. These provide leads for development of drugs to re-sensitise tumours to cross-linking agents such as cisplatin.
01.11.19 Checkpoint inhibition of origin firing prevents DNA topological stress
Morafraile et al. from the Zegerman lab with UK colleagues reveal that the role of limiting the number of DNA replication initiation events is to prevent DNA topological stress, which may be relevant for cancer treatment with both topoisomerase and checkpoint inhibitors.
04.11.19 Regeneration mechanism uncovered in adult mouse liver tissue provides target for drug design
The Huch lab and collaborators have uncovered a novel molecular mechanism in mice that allows damaged adult liver cells to regenerate, paving the way for design of drugs to boost regeneration in conditions such as cirrhosis or other chronic liver diseases where regeneration is impaired.
11.10.19 ERC Synergy Grant for Jackson lab in European collaborative project on DNA damage response
Steve Jackson's lab is the first in Cambridge to be awarded a new European Research Council Synergy Grant under the Horizon 2020 funding programme from the European Union. Steve's research collaborators are in Switzerland and Austria.
09.10.19 Rawlins lab researchers are captured in oils for The Rising Tide exhibition at UL
Artist Caroline Walker watched and photographed researchers at the bench in the Rawlins lab at the Gurdon Institute and created a stunning, large-format oil painting for the University Library's upcoming exhibition, 'The Rising Tide: Women at Cambridge'.
12.09.19 Blocking mitochondria-generated energy reduces brain tumour growth and stem cell differentiation
Jelle van den Ameele and Andrea Brand studied mitochondrial metabolism in normal brain development and in brain tumours in the fruit fly, showing that it contributes to stem cell differentiation as well as cell proliferation
26.09.19 Meri Huch receives BINDER Innovation Prize 2019 from German Society for Cell Biology
The annual prize, founded by German company BINDER GmbH, is awarded for outstanding cell biological research with a focus on cell culture or the use of cell cultures
11.09.19 'Herculean' project catalogues over 4,500 mutational signatures of the Yeast Knockout Collection
Jackson lab researchers create unique genomics resource from > 4,500 yeast strains to identify genes protecting cells from DNA alterations that are implicated in human disease and ageing
15.08.19 Defining two populations of stem cells in the gastric corpus epithelium
Simons, Koo and colleagues define the identity and dynamics of adult gastric isthmus stem cells, which maintain the rapid turnover of the upper part of the corpus gland
29.07.19 Revealing the cellular mechanism of sebaceous gland development in mouse
Ben Simons and collaborators in Copenhagen and Vienna probe the origin, development and maintenance of the sebaceous gland in mouse skin, using clonal fate studies.
21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance
This study from the Miska lab, with colleagues at Imperial, provides a first reference of house sparrow sperm small RNA as an attempt to uncover their role in the transmission of the effects of paternal age on the offspring.
27.04.19 Discovering gene circuits using machine-learning algorithms
Tom Hiscock in the Simons group applied a computational approach to generate algorithms describing natural gene circuits and for designing circuits in synthetic biology. The work is published in BMC Bioinformatics
13.05.19 Doctorate Honoris Causa conferred on Sir John Gurdon at Scuola Superiore Sant’Anna of Pisa
The Scuola Superiore Sant’Anna of Pisa confers an honorary doctorate in Translational Medicine on John Gurdon
29.05.19 Bipotent stem cells in embryonic liver give rise to hepatocytes and cholangiocytes
Prior et al. in the Huch and Simons labs use lineage tracing, sc-RNA seq and organoid culture to show that Lgr5 is a marker for a sub-population of bipotent liver progenitor cells
