skip to primary navigationskip to content

19.03.18 Invitation to a special seminar by Jody Rosenblatt, Huntsman Cancer Institute, Utah, USA

last modified Mar 19, 2018 02:54 PM
Join us to hear about Jody Rosenblatt's research into the role of cell extrusion from epithelia, in health and disease

Everyone is welcome to attend

Jody Rosenblatt poster

Abstract: What links cell division to cell death in order to maintain constant epithelial cell densities? We found that mechanical forces control both processes: cell stretching triggers rapid cell division, whereas, crowding causes cell death by a process we call ‘epithelial extrusion’, in which cells fated to die are seamlessly squeezed out from epithelia. Extrusion is essential for maintaining correct epithelial cell densities. We find a growing number of diseases result from misregulation of extrusion. Excessive extrusion disrupts epithelial barrier, causing inflammation and infection hyper-sensitivity after an asthma attack. Conversely, oncogenic mutations hijack apical extrusion signaling and promote a class of aggressive tumors, which invade via a new mechanism—basal extrusion.

Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

combinedLogo x3 trans2018


Share this

scmap: projection of single-cell RNA-seq data across data sets

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

The developmental origin of brain tumours: a cellular and molecular framework

Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst

Validating the concept of mutational signatures with isogenic cell models

A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells

Targeting NAT10 enhances healthspan and lifespan in a mouse model of human accelerated aging syndrome

An alternative mode of epithelial polarity in the Drosophila midgut

Detection of functional protein domains by unbiased genome-wide forward genetic screening

Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium

Genome organization at different scales: nature, formation and function

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations


Link to full list on PubMed