skip to primary navigationskip to content
 

05.03.18 Invitation to a special seminar by Ross Cagan, Icahn School of Medicine at Mt Sinai, New York

last modified Mar 05, 2018 01:58 PM
Come and hear Ross Cagan describe his 'fly-to-bedside' approach of developing therapeutics based on models of disease in Drosophila

Everyone is welcome to attend

RossCaganSpecialSeminar

Abstract: Our deepening knowledge of the genomic and physiological basis of disease has led to important advances in our understanding of mechanism and of therapeutics. This growing knowledge has also highlighted important challenges including disease complexity in the context of the whole body. I will discuss our use of Drosophila to explore and address this complexity in thyroid and colorectal cancers, including developing lead therapeutic compounds and a fly-to-bedside clinical trial. I will also discuss how our platform can be leveraged to embrace complexity in other diseases that are readily modelled in flies.

Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

combinedLogo x3 trans2018

 

Share this

Immune Cell Dynamics Unfolded by Single-Cell Technologies

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

SLAM-ITseq: Sequencing cell type-specific transcriptomes without cell sorting

SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements

scmap: projection of single-cell RNA-seq data across data sets

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

The developmental origin of brain tumours: a cellular and molecular framework

Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst

Link to full list on PubMed