skip to primary navigationskip to content
 

16.03.18 Invitation to a special seminar by Cayetano Gonzalez, IRB-Barcelona & Barcelona Institute of Science and Technology, Spain

last modified Mar 16, 2018 09:00 AM
Join us to hear Cayetano Gonzalez describe his research on experimentally induced tumours in Drosophila as a means to understand the molecular and cellular processes in neoplasia

Everyone is welcome to attend

Gonzalez Special seminar

Abstract: We are using tumours that can be experimentally induced in Drosophila to understand the molecular and cellular processes that drive neoplasia. Our current work is focused on three research lines. We are investigating the extent of genome instability (GI) and its contribution to malignancy. We are also studying the tumorigenic effect of ectopic somatic expression of germline genes, a trait that has been known for decades in human cancer (i.e. cancer-testis antigens), but whose functional relevance remains uncertain. Finally, we are investigating how centrosome dysfunction can bring about neoplasias derived from neural progenitors. Our studies also shed light on the mechanisms of normal cell division during development. Thus, for instance, fluorescent clonal reporters generated to study GI in tumours have revealed an intriguingly high level of GI in certain wild-type cell lineages. Likewise, our work on centrosomes in neural progenitors has identified a protein that is a key determinant of ciliogenesis and centriole ultrastructure.

Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

combinedLogo x3 trans2018

 

Share this

scmap: projection of single-cell RNA-seq data across data sets

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

The developmental origin of brain tumours: a cellular and molecular framework

Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst

Validating the concept of mutational signatures with isogenic cell models

A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells

Targeting NAT10 enhances healthspan and lifespan in a mouse model of human accelerated aging syndrome

An alternative mode of epithelial polarity in the Drosophila midgut

Detection of functional protein domains by unbiased genome-wide forward genetic screening

Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium

Genome organization at different scales: nature, formation and function

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations

 

Link to full list on PubMed