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16.03.18 Invitation to a special seminar by Cayetano Gonzalez, IRB-Barcelona & Barcelona Institute of Science and Technology, Spain

last modified Mar 16, 2018 09:00 AM
Join us to hear Cayetano Gonzalez describe his research on experimentally induced tumours in Drosophila as a means to understand the molecular and cellular processes in neoplasia

Everyone is welcome to attend

Gonzalez Special seminar

Abstract: We are using tumours that can be experimentally induced in Drosophila to understand the molecular and cellular processes that drive neoplasia. Our current work is focused on three research lines. We are investigating the extent of genome instability (GI) and its contribution to malignancy. We are also studying the tumorigenic effect of ectopic somatic expression of germline genes, a trait that has been known for decades in human cancer (i.e. cancer-testis antigens), but whose functional relevance remains uncertain. Finally, we are investigating how centrosome dysfunction can bring about neoplasias derived from neural progenitors. Our studies also shed light on the mechanisms of normal cell division during development. Thus, for instance, fluorescent clonal reporters generated to study GI in tumours have revealed an intriguingly high level of GI in certain wild-type cell lineages. Likewise, our work on centrosomes in neural progenitors has identified a protein that is a key determinant of ciliogenesis and centriole ultrastructure.

Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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