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Abstract: We work to unravel the biological complexity of tissue homeostasis since its disintegration underlies cancer and disease. Control over structural scaffolds, stem & progenitor cell populations, and instructive signals is essential for healthy aging of tissues. Our focus on mammary gland biology has led to us identify critical hormonal signals responsible for triggering significant stem/progenitor cell expansions in the adult breast, and signaling pathways central to this process. Understanding the mammary stem cell dynamics informs us about breast cancer risk as well as offers new strategies for developing chemopreventive options.