skip to primary navigationskip to content
 

19.02.18 Invitation to a special seminar by Eric Miska, Gurdon Institute

last modified Mar 05, 2018 01:45 PM
Come and hear Eric Miska talk about his research on in-vivo RNA structures, including the Zika virus

Everyone is welcome to attend

EMiskaPoster 540px

Abstract: The genomes of RNA-viruses are dynamic and adopt certain structures to facilitate replication, translation and evade cellular immunity while inside their host cell cytoplasm. However, a lack of methodology has limited our knowledge to the structure of encapsidated genomes inside mature virus particles or in-vitro folded viral RNAs, hence uncoupled from infection. Here we present a genome-wide method for probing RNA base-pairing during viral infection, and utilize it to study the genomic structure of Zika virus inside human cells. We reveal multiple structural motifs along the virus genome and provide a physical evidence for a cyclic structure the virus RNA adopts during replication. We highlight unforeseen base-pairing between the Zika genome and human small non-coding RNAs. Our methodology opens up opportunities for characterization of pathogenic RNA genomes while propagating inside their host and offers a platform for development of new RNA-based therapeutic strategies.

Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

combinedLogo x3 trans2018

 

Share this

A walk through tau therapeutic strategies

Labeling strategies matter for super-resolution microscopy: a comparison between HaloTags and SNAP-tags

Stem Cell-Derived Human Gametes: The Public Engagement Imperative

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis

Constrained actin dynamics emerges from variable compositions of actin regulatory protein complexes

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

Drosophila IMP regulates Kuzbanian to control the timing of Notch signalling in the follicle cells

Challenges in unsupervised clustering of single-cell RNA-seq data

Engineering vasculature: Architectural effects on microcapillary-like structure self-assembly

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease

Helicase subunit Cdc45 targets the checkpoint kinase Rad53 to both replication initiation and elongation complexes after fork stalling

Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche

Link to full list on PubMed