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19.02.18 Invitation to a special seminar by Eric Miska, Gurdon Institute

last modified Mar 05, 2018 01:45 PM
Come and hear Eric Miska talk about his research on in-vivo RNA structures, including the Zika virus

Everyone is welcome to attend

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Abstract: The genomes of RNA-viruses are dynamic and adopt certain structures to facilitate replication, translation and evade cellular immunity while inside their host cell cytoplasm. However, a lack of methodology has limited our knowledge to the structure of encapsidated genomes inside mature virus particles or in-vitro folded viral RNAs, hence uncoupled from infection. Here we present a genome-wide method for probing RNA base-pairing during viral infection, and utilize it to study the genomic structure of Zika virus inside human cells. We reveal multiple structural motifs along the virus genome and provide a physical evidence for a cyclic structure the virus RNA adopts during replication. We highlight unforeseen base-pairing between the Zika genome and human small non-coding RNAs. Our methodology opens up opportunities for characterization of pathogenic RNA genomes while propagating inside their host and offers a platform for development of new RNA-based therapeutic strategies.

Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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