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21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance

last modified Jun 07, 2019 04:21 PM
This study from the Miska lab, with colleagues at Imperial, provides a first reference of house sparrow sperm small RNA as an attempt to uncover their role in the transmission of the effects of paternal age on the offspring.
21.05.19 Sparrows: A new model organism for studying role of small RNAs in inheritance

House sparrows

Mature sperm small-RNA profile in the sparrow: implications for transgenerational effects of age on fitness

Matsushima W et al. (2019) Environ Epigenet 5(2): dvz007. DOI: 10.1093/eep/dvz007.

 

 

Abstract from the paper

Mammalian sperm RNA has recently received a lot of interest due to its involvement in epigenetic germline inheritance. Studies of epigenetic germline inheritance have shown that environmental exposures can induce effects in the offspring without altering the DNA sequence of germ cells.

Most mechanistic studies were conducted in laboratory rodents and C.elegans while observational studies confirm the phenotypic phenomenon in wild populations of humans and other species including birds. Prominently, paternal age in house sparrows affects offspring fitness, yet the mechanism is unknown.

This study provides a first reference of house sparrow sperm small RNA as an attempt to uncover their role in the transmission of the effects of paternal age on the offspring. In this small-scale pilot, we found no statistically significant differences between miRNA and tRNA fragments in aged and prime sparrow sperm.

These results indicate a role of other epigenetic information carriers, such as distinct RNA classes, RNA modifications, DNA methylation and retained histones, and a clear necessity of future studies in wild populations.

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Learn more about research in the Miska lab.

Hear Eric Miska describe his research in this YouTube video.

Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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