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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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Integrin signaling downregulates filopodia in muscle-tendon attachment

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development

DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4

Natural Genetic Variation in a Multigenerational Phenotype in C. elegans

On the origin of the human germline

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells 

Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency

Immune Cell Dynamics Unfolded by Single-Cell Technologies

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

SLAM-ITseq: Sequencing cell type-specific transcriptomes without cell sorting

SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements

scmap: projection of single-cell RNA-seq data across data sets

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

The developmental origin of brain tumours: a cellular and molecular framework

 

 

Link to full list on PubMed