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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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Our recent publications

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

In vivo modeling of human neuron dynamics and Down syndrome

Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate

A newly discovered neural stem cell population is generated by the optic lobe neuroepithelium during embryogenesis in Drosophila melanogaster

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

Staged profiling of sperm development in sync

A sub-population of Foxj1 expressing, non-myelinating Schwann cells of the peripheral nervous system contribute to Schwann cell remyelination in the central nervous system

Branch-recombinant Gaussian processes for analysis of perturbations in biological time series

COMRADES determines in vivo RNA structures and interactions

The transcription factor SoxD controls neuronal guidance in the Drosophila visual system

Targeted DamID reveals differential binding of mammalian pluripotency factors

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

A transmissible RNA pathway in honey bees

Terminal uridylyltransferases target RNA viruses as part of the innate immune system

Human lung development: recent progress and new challenges

Link to full list on PubMed