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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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Our recent publications

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

Drosophila IMP regulates Kuzbanian to control the timing of Notch signalling in the follicle cells

Challenges in unsupervised clustering of single-cell RNA-seq data

Engineering vasculature: Architectural effects on microcapillary-like structure self-assembly

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease

Helicase subunit Cdc45 targets the checkpoint kinase Rad53 to both replication initiation and elongation complexes after fork stalling

Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans

3D Nanoscopy with Sub-60 nm Resolution Deep Inside Tissue Using Adaptive Optics

Predicting the mutations generated by repair of Cas9-induced double-strand breaks

Link to full list on PubMed