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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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Our recent publications

Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

miR-7 buffers differentiation in the developing Drosophila visual system

The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription

Delayed APC/C activation extends the first mitosis of mouse embryos

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci

Link to full list on PubMed