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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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Our recent publications

Predicting the mutations generated by repair of Cas9-induced double-strand breaks

Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe

Whole-genome sequences of Malawi cichlids reveal multiple radiations interconnected by gene flow

Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery

The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans

Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma

Chromatin accessibility dynamics across C. elegans development and ageing

Statistical theory of branching morphogenesis

An alternative mode of epithelial polarity in the Drosophila midgut

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

In vivo modeling of human neuron dynamics and Down syndrome

Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate

A newly discovered neural stem cell population is generated by the optic lobe neuroepithelium during embryogenesis in Drosophila melanogaster

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

Staged profiling of sperm development in sync

Link to full list on PubMed