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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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Our recent publications

Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium

Genome organization at different scales: nature, formation and function

Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci

A niche of trophoblast progenitor cells identified by integrin α2 is present in first trimester human placentas

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications

Mixed analytical-stochastic simulation method for the recovery of a Brownian gradient source from probability fluxes to small windows

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

Live imaging of neurogenesis in the adult mouse hippocampus

Link to full list on PubMed