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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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Our recent publications

Ancestral Hybridisation Facilitated Species Diversification in the Lake Malawi Cichlid Fish Adaptive Radiation

Mapping and editing animal mitochondrial genomes: can we overcome the challenges?

The role of integrins in Drosophila egg chamber morphogenesis

A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations

Genetic predisposition to mosaic Y chromosome loss in blood

MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

Checkpoint inhibition of origin firing prevents DNA topological stress

Small Molecule Inhibition of UBE2T/FANCL-mediated Ubiquitylation in the Fanconi Anemia Pathway

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells

Mitochondrial heteroplasmy beyond the oocyte bottleneck

Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development

Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

Testing the role of SOX15 in human primordial germ cell fate

Genome architecture and stability in the Saccharomyces cerevisiae knockout collection

Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination

Link to full list on PubMed