Ben Simons
Senior group leaderResearch summary
Mechanisms of stem cell fate in tissue development, maintenance and disease
How do stem and progenitor cells regulate their fate behaviour to specify and maintain tissues? During development, cell proliferation and differentiation must be coordinated with collective cell movements to specify organs of the correct size, pattern and composition. In the adult, stem cells must regulate a precise balance between proliferation and differentiation to maintain tissue homeostasis.
To address the mechanisms that regulate stem and progenitor cell fate, we combine cell lineage-tracing approaches and single-cell gene expression profiling with concepts and methods from statistical physics and mathematics. Applied to epithelial tissues, we have shown how common principles of self-organisation and emergence provide predictive insights into the cellular mechanisms that regulate tissue development, maintenance and repair.
As well as questioning the nature of stem cell identity and function, these studies emphasize the role of cell fate stochasticity and state flexibility, and establish a quantitative platform to investigate pathways leading to cancer initiation and progression.
Cell lineage tracing in the stomach corpus. Genetic lineage tracing using a multicolour confetti reporter system reveals the compartmentalisation of the mouse stomach corpus gland. (Credit: Juergen Fink and Seungmin Han.)
Selected publications
-
Aztekin C et al. (2021) Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs. Development 148 (11): dev199158. DOI: 10.1242/dev.199158.
-
Yum MK et al. (2021) Tracing oncogene-driven remodelling of the intestinal stem cell niche. Nature 594(7863):442-447. DOI: 10.1038/s41586-021-03605-0.
-
McGinn J et al. (2021) A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium. Nat Cell Biol 23(5):511-525. DOI: 10.1038/s41556-021-00679-w.
-
Nakamura Y et al (2021) Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice. Cell Stem Cell 28(8):1443-1456.e7. DOI: 10.1016/j.stem.2021.03.016.
-
Sznurkowska MK et al. (2020) Tracing the cellular basis of islet specification in mouse pancreas. Nat Commun 11(1):5037. DOI: 10.1038/s41467-020-18837-3.
-
Aragona M et al. (2020) Mechanisms of stretch-mediated skin expansion at single-cell resolution. Nature 584(7820):268-273. DOI: 10.1038/s41586-020-2555-7.
-
Hannezo E et al. (2017) A unifying theory of branching morphogenesis. Cell 171: 242–255. DOI: 10.1016/j.cell.2017.08.026.
Biography
Prof Ben Simons PhD FRS FMedSci
Royal Society EP Abraham Professor, Herchel Smith Professor of Physics, Affiliate of the University Department of Applied Mathematics and Theoretical Physics
Research group
-
Dr Lemonia Chatzeli
Research Associate
-
Dr Adrien Hallou
Herchel Smith Postdoctoral Research Fellow
-
Joel Hochstetter
PhD Student
-
Dr Qiuyu Lian
Research Associate
-
Dr Sanne van Neerven
Research Associate
-
Yanbo Yin
PhD Student