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Epigenetic programme is essential for normal development

The Surani lab’s new paper describes how the loss of a maternally inherited epigenetic modifier, G9a, leads to establishment of an aberrant regulatory network in preimplantation embryos, developmental delay and destabilisation of cell-fate choices. These results highlight the importance of epigenetic programming at the onset of development.

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New target for increasing lifespan in premature ageing syndromes

The Jackson lab's new paper identifies the enzyme NAT10 as a target for therapeutic approaches to treating Hutchinson-Gilford Progeria Syndrome. Using a mouse model of the disease they found that chemical inhibition or genetic deregulation of NAT10 significantly improved the health and extended the lifespan of the mice. These results open up the possibility of treating sufferers of this and other accelerated ageing syndromes.

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Method for identifying drug targets and predicting resistance mechanisms

A new protocol published by the Jackson lab details a genome-wide screening approach to detecting suppressor mutations in yeast or haploid mammalian cells. They use it to identify chemical-genetic suppressors of sensitivity to two drugs interacting with DNA damage repair pathways, camptothecin and olaparib, and to provide insights into functionally relevant protein domains targeted by these compounds.

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Finding the genes required for 'hairy' cells

Ciliated cells are necessary to help clear the airways of particles and debris. The Rawlins lab describe an in vitro assay using explants of embryonic mouse trachea that enabled them to identify two genes, Fank1 and Jazf1, as novel regulators of stem cell differentiation into ciliated cells. The paper's first author Jo-Anne Johnson is interviewed about her work in the same issue of Biology Open.

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New type of stem cell identified in brain

Otsuki and Brand's 'Science' paper reports their discovery in the brain of a new type of quiescent stem cell (known as a ‘G2 quiescent stem cell’) with higher regenerative potential than quiescent stem cells identified previously. Importantly, G2 quiescent stem cells awaken to make neurons and glia much faster than known quiescent stem cells, making them attractive targets for therapeutic design.

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Do neurons in a culture dish think?

David Blandy's video 'The Borked Brain' is the output from his collaboration with scientists in the Livesey lab, as part of our project curated through Kettle's Yard, Experiments in Art & Science. Watch and consider with David whether skin cells reprogrammed into neurons to grow and make connections in a culture dish may be generating thoughts, like a whole brain...

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Success in renewing our AS Bronze

We are very pleased to announce that our application to renew our Athena SWAN Bronze Award, first granted in 2014, has been successful. Thanks go to the Equality Working Group for implementing practices and collecting data to provide evidence on the improvements we've made in equality, diversity and a supportive environment for all our members.

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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

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scmap: projection of single-cell RNA-seq data across data sets

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

The developmental origin of brain tumours: a cellular and molecular framework

Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst

Validating the concept of mutational signatures with isogenic cell models

A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells

Targeting NAT10 enhances healthspan and lifespan in a mouse model of human accelerated aging syndrome

An alternative mode of epithelial polarity in the Drosophila midgut

Detection of functional protein domains by unbiased genome-wide forward genetic screening

Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium

Genome organization at different scales: nature, formation and function

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations

 

Link to full list on PubMed