Charles Bradshaw
Head of Sequencing & Scientific ComputingRole summary
The Institute has an Illumina NovaSeq 6000 Sequencer, which is available to researchers both in the Institute and the wider University. This sequencer is managed by Charles and is run by Kay Harnish.
Charles also assists with all scientific users of computing within the Institute. This includes managing the Institute’s High Performance Compute cluster (1,216 cores and 1.5PB of storage) and scientific virtual machine cluster along with smaller optimised platforms for use within the building. Systems range from dedicated rack mounted servers to Raspberry Pis with bespoke electronics and software. This support allows scientists to work on their research, knowing that they have optimal compute resources.
Charles has extensive experience in scientific data management, having managed the Institute's high throughput sequencing data since 2010.
Selected publications
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More RP, Warrier V, Brunel H et al. (2023) Identifying rare genetic variants in 21 highly multiplex autism families: the role of diagnosis and autistic traits. Mol Psychiatry 28, 2148–2157. DOI: 10.1038/s41380-022-01938-4.
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Pacini CE, Bradshaw CR, Garrett NJ et al. (2019) Characteristics and homogeneity of N6-methylation in human genomes. Sci Rep 9, 5185. DOI: 10.1038/s41598-019-41601-7.
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Broutier L, Mastrogiovanni G, Verstegen M. et al. (2017) Human primary liver cancer–derived organoid cultures for disease modeling and drug screening. Nat Med 23, 1424–1435. DOI: 10.1038/nm.4438.
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Koziol M, Bradshaw C, Allen G et al. (2016) Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. Nat Struct Mol Biol 23, 24–30 (2016). DOI: 10.1038/nsmb.3145.
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Collinet C, Stöter M, Bradshaw C et al. (2010) Systems survey of endocytosis by multiparametric image analysis. Nature 464, 243–249. DOI: 10.1038/nature08779.
Biography
Dr Charles Bradshaw BSc (Hons) MSc
Charles’s undergraduate degree was in Biochemistry at the University of Sussex, after which he completed an MSc in Bioinformatics at the University of Exeter followed by a PhD at the Max Planck Institute of Cell Biology and Genetics in Dresden, Germany. His thesis covered detecting weakly conserved functional domains and gaining novel insights into genome-wide screens in humans and C. elegans.
Charles joined the Gurdon in 2010 running the Bioinformatics Core. In this period he worked with almost all the 17 research groups in the institute and was an author on over 20 publications. He also established the High Performance Compute facilities in the institute. In 2017 his role diverged into Scientific Computing as the High Performance Compute grew with more than 100 users and became an established facility for the institute.
Charles has collaborated with the ARC in Cambridge on Autism Genetics. This work was published in 2022 in Molecular Psychiatry.
In 2022 Charles also became the manager of the Sequencing facility, using his established knowledge and experience with Illumina and Oxford Nanopore sequencing to run the facility and its NovaSeq 6000.