The ‘Heat Mapping’ temporary tattoo was designed for the Surani lab group to represent their research as part of the Tattoo my Science project.
We are investigating how cells in the developing embryo decide what type of cell to become. We are especially looking at how the cells that later become sperm or eggs develop.
In order to understand this, we create ’heat maps’ that allow us to compare which genes are turned on or off in different cells at different times in their development.
Design by Naoko Iris
Surani Lab Group
The human germline
We study primordial germ cells (PGCs), precursors to eggs and sperm, in the early embryo. We have established principles of early human development with a focus on human PGC (hPGC) specification. A unique epigenetic resetting follows in the germline after hPGC specification. Our work shows that SOX17 is the key regulator of human, but not mouse, germ cell fate. By developing in vitro models, and with authentic hPGCs from human embryos, we have also established how pluripotent stem cells gain competence for germ cell and somatic fates in human.
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