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Emma Rawlins


2017 RawlinsEmma Rawlins PhD, MRC Senior Non-Clinical Fellow, Member of the Department of Pathology.

Europe PMC | Pubmed

 

 

 

  

Stem and progenitor cells in the mammalian lung

How do stem cells build and maintain the lung? The complicated three-dimensional structure of our lungs is essential for respiration and host defence. Building this structure relies on the correct sequence of division and differentiation events by lung progenitor cells, which also maintain the slowly turning-over airway epithelium in the adult.

How is the production of different cell types controlled in embryonic development and adult maintenance? We apply mouse genetics, live imaging, single-cell molecular analysis and mathematical modelling to understand lung stem cells, with a longer-term aim of directing endogenous lung cells to repair, or regenerate, diseased tissue.

In the adult lung we focus on the cellular mechanisms that maintain stem cell quiescence at steady-state, but allow a rapid repair response when needed. In the embryonic lung we study a population of multipotent progenitors that undergo steroid-induced changes in competence during development.

We have recently established conditions for growing these embryonic progenitors as self-renewing organoids from human tissue samples, and are using them to focus our research on normal human lung development and conditions related to premature birth.

Selected publications:

Nikolić MZ, Caritg O, Jeng Q, Johnson J, Sun D, Howell KJ, Brady JL, Laresgoiti U, Allen G, Butler R, Zilbauer M, Giangreco A, Rawlins EL (2017) Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids. Elife Jun 30;6. pii: e26575. DOI: 10.7554/eLife.26575. PMC5555721.

Balasooriya GI, Goschorska M, Piddini E, Rawlins EL (2017) FGFR2 is required for airway basal cell self-renewal and terminal differentiation. Development 144, 1600-1606. PMC5450841.

• Laresgoiti U, Nikolić MZ, Rao C, Brady JL,  Richardson RV, Batchen EJ, Chapman KE and Rawlins EL (2016) Lung epithelial tip progenitors integrate Glucocorticoid and STAT3-mediated signals to control progeny fate. Development 143(20): 3686-3699. PMC5087639.

• Balasooriya GI, Johnson J, Basson MA, Rawlins EL (2016) An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. Developmental Cell 37(1):85-97. PMC4825408.

• Wagstaff L, Goschorska M, Kozyrska K, Duclos G, Kucinski I, Chessel A, Hampton-O’Neil L, Bradshaw CR, Allen GE, Rawlins EL, Silberzan P, Carazo Salas RE and Piddini E (2016) Mechanical cell competition kills cells via induction of lethal p53 levels. Nat Commun. 7:11373. DOI:10.1038/ncomms11373. PMC4848481.

• Watson JK, Rulands S, Wilkinson AC, Wuidart A, Ousset M, Van Keymeulen A, Göttgens B, Blanpain C, Simons BD, Rawlins EL (2015) Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow Turnover Airway Epithelium. Cell Reports 12:1-12. PMC4518462.

Rawlins Group 2017

Video: Meet Emma Rawlins

Co-workers

Quitz Jeng • Heleen Kool • Florence Leroy • Kyungtae Lim • Shuyu Liu • Vishal Menon • Vanesa Sokleva • Dawei Sun

A factsheet on the EuroStemCell website, by Adam Giangreco (UCL) and Emma Rawlins; updated 2018.

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