Immunostaining of a human female genital ridge in the 8th week of embryonic development depicting levels of H3K4me1 (red) and POU5F1 (green) in gonadal somatic cells and primordial germ cells (PGCs). Note that POU5F1-positive PGCs exhibit higher H3K4me1 levels than the surrounding somatic cells.
Publication - Surani

Human germline rejuvenation entails heterochromatin remodelling

Reduced levels of repressive histone modifications in reset hPGCs

January 18, 2023

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Human primordial germ cell-like cells (yellow) co-cultured with human hindgut organoids (magenta/cyan).
Publication - Surani

Human primordial germ cell-like cell development in hindgut organoids

Different precursors impact human primordial germ cell-like cell development.

January 5, 2023

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C. elegans adult germline expressing a GFP construct. The specific expression of the construct was driven by a TE-co-opted promoter.
Publication - Ahringer

Transposable elements recruited as promoters in the Caenorhabditis germline

Transposon co-option in the Caenorhabditis germline

December 16, 2022

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Rawlins group_Human fetal lung tissue staining image showing alveolar development
Publication - Rawlins

Novel human lung organoids to study development and disease

Building the human lung

December 8, 2022

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Rawlins group_Human fetal lung tissue staining image describing a signalling niche for airway development
Publication - Rawlins

Human fetal lung cell atlas released

Single-cell lung atlas will provide foundational dataset

December 8, 2022

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A layer of Drosophila cells with nucleus marked red and mitochondria marked green. Image Klunicka et al, Ma Lab.
Publication - Ma

Identifying the molecular machinery for mitochondrial genome maintenance

REC repairs mitochondrial DNA by homologous recombination

November 10, 2022

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The simple layer of epithelial cells in the fruit fly midgut, with intestinal stem cells (ISC, smaller cells) situating at the basal side. Nuclear in cyan, alpha-Spectrin (cell cortical region) in magenta, and occluding septate junction in yellow.
Publication - St Johnston

How polarised epithelial cells grow “up” without breaking the barrier

Similarities between fly midgut polarisation and lumen formation in mammalian epithelial cysts

September 28, 2022

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Kyungtae Lim in the Rawlins lab working at the tissue culture cabinet
Publication - Brand - Jackson - Rawlins

Identifying SOX9 as major regulator of lung progenitor self-renewal

SOX9 controls lung epithelial progenitor self-renewal

September 19, 2022

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Human developing lung section under microscope
Publication - Rawlins

Engaging the public with fundamental biology

Creating a model for involving the public in fundamental research

September 15, 2022

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