![Shelves with microscopes lined up](https://www.gurdon.cam.ac.uk/wp-content/uploads/2021/10/IMG_3135-1024x1024.jpg)
Zeiss Z1 light-sheet microscope
![Technical spec and photo of the Zeiss Z1 Lightsheet microscope](https://www.gurdon.cam.ac.uk/wp-content/uploads/2022/03/Zeiss-Z1-Lightsheet-spec_photo-1024x536.png)
![Sample of cleared lung tissue imaged by lightsheet microscope](https://www.gurdon.cam.ac.uk/wp-content/uploads/2022/03/Lung_tissue-1024x992.jpg)
Technology focus
Light-sheet microscopy is a fluorescence technique that projects a thin ‘sheet’ of excitation light perpendicular to the direction of observation. Only the focus plane is illuminated making it gentler on the sample and thus ideal for long-term live imaging of transparent samples such as zebrafish or organoids.
Light-sheet microscopy is also well suited to imaging larger cleared samples, such as this 6mm-cubed piece of cleared lung tissue, because of the potential imaging speed. (Sample prepared and imaged by Tessa Hughes, Rawlins lab.)