Surani

Human primordial germ cells in developing gonads
Publication - Surani

Advances in the in vitro derivation of human gametes bring hopes, but raises questions

November 14, 2023

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Advanced human primordial germ cell like cells induced in vitro by DMRT1/SOX17 colonized in mouse embryonic testicular organoids
Publication - Surani

A unique role for DMRT1 in the onset of human gametogenesis

Advanced in vitro models for human primordial germ cell development revealed key roles of DMRT1 for germline commitment

September 14, 2023

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Microinjector on microscope stage from Surani lab
Publication - Surani

Tracing the origin and segregation of the human germline

Elucidating the precursors of the human germline in gastrulating embryos

May 22, 2023

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Immunostaining of a human female genital ridge in the 8th week of embryonic development depicting levels of H3K4me1 (red) and POU5F1 (green) in gonadal somatic cells and primordial germ cells (PGCs). Note that POU5F1-positive PGCs exhibit higher H3K4me1 levels than the surrounding somatic cells.
Publication - Surani

Human germline rejuvenation entails heterochromatin remodelling

Reduced levels of repressive histone modifications in reset hPGCs

January 18, 2023

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Human primordial germ cell-like cells (yellow) co-cultured with human hindgut organoids (magenta/cyan).
Publication - Surani

Human primordial germ cell-like cell development in hindgut organoids

Different precursors impact human primordial germ cell-like cell development.

January 5, 2023

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Microinjector setup in Surani lab
Publication - Surani

Roadmap to guide in vitro gonadogenesis

A spatiotemporal map of human and mouse gonadal differentiation

July 6, 2022

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Surani lab microinjection rig
Publication - Surani

Untangling the mechanism of human primordial germ cell specification

SOX17 enhancers are the critical components in the regulatory circuitry of germline competence

April 11, 2022

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Surani lab microinjection rig
Publication - Surani

Tracing the origin of PGCs in rabbit

Surani lab study establishes rabbit embryo as surrogate model for early human development

October 12, 2021

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