Surani

Immunostaining of a human female genital ridge in the 8th week of embryonic development depicting levels of H3K4me1 (red) and POU5F1 (green) in gonadal somatic cells and primordial germ cells (PGCs). Note that POU5F1-positive PGCs exhibit higher H3K4me1 levels than the surrounding somatic cells.
Publication - Surani

Human germline rejuvenation entails heterochromatin remodelling

Reduced levels of repressive histone modifications in reset hPGCs

January 18, 2023

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Human primordial germ cell-like cells (yellow) co-cultured with human hindgut organoids (magenta/cyan).
Publication - Surani

Human primordial germ cell-like cell development in hindgut organoids

Different precursors impact human primordial germ cell-like cell development.

January 5, 2023

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Microinjector setup in Surani lab
Publication - Surani

Roadmap to guide in vitro gonadogenesis

A spatiotemporal map of human and mouse gonadal differentiation

July 6, 2022

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Surani lab microinjection rig
Publication - Surani

Untangling the mechanism of human primordial germ cell specification

SOX17 enhancers are the critical components in the regulatory circuitry of germline competence

April 11, 2022

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Surani lab microinjection rig
Publication - Surani

Tracing the origin of PGCs in rabbit

Surani lab study establishes rabbit embryo as surrogate model for early human development

October 12, 2021

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