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Analysing the diversity of RNA modifications

The Miska lab, with Chemistry’s Balasubramanian lab and other colleagues, use a suite of chemical techniques to analyse the complete C. elegans transcriptome (i.e. all the species of RNA molecules) for modifications, and then track how these respond to the environmental stressors of heat or starvation.

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Suppressor screen in yeast identifies mechanism for anti-cancer drug resistance

Using yeast as a model system to understand how cells might acquire resistance to the anti-cancer drug camptothecin, the Jackson lab define a mechanism that involves control of DNA topology and appears to be conserved in other eukaryotic cells, including human cells.

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Inherited Stella protein regulates embryo gene activity

The Surani lab with colleagues at EMBL show that soon after fertilisation, a critical portion of the embryonic genome is switched on through the actions of the maternally inherited protein Stella, in part through controlling the activation of transposable elements.

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Role for FGFR2 in airway stem cell renewal and differentiation

The Rawlins and Piddini labs show that signalling through FGF receptor 2 is required in airway basal stem cells for self-renewing divisions and differentiation. This pathway maintains homeostasis in the adult airway epithelium, and may be at fault in cancer or degenerative disease.

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Zoom Box competition winners visit the Institute

Our photo competition winner Neve (right) and her sister Sophia, a runner-up, visited the Institute to receive their microscope prizes from our Public Engagement Officer, Helene Doerflinger. The girls were treated to a tour of some of our more complex instruments such as the Opera robotic imaging machine and the Super Resolution microscope.

See the winning Zoom Box photos

We're recruiting postdocs!

Several group leaders are seeking applications for postdoc positions. Come and join our world-leading scientists and enjoy the many benefits of postdoc life in Cambridge.

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Jackson lab celebrates 25 years with a reunion party

Prof Steve Jackson is one of the Gurdon Institute's longer-serving group leaders. Just before Easter his lab celebrated their 25th anniversary by gathering over 70 former and current members together. Lab alumni from as far afield as Japan, Canada, USA and Israel attended the two-day conference, dinner and party, and shared this marvellous cake from Worldwide Cancer Research, one of the funders of Steve's research.

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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

 

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