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Inherited Stella protein regulates embryo gene activity

The Surani lab with colleagues at EMBL show that soon after fertilisation, a critical portion of the embryonic genome is switched on through the actions of the maternally inherited protein Stella, in part through controlling the activation of transposable elements.

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Role for FGFR2 in airway stem cell renewal and differentiation

The Rawlins and Piddini labs show that signalling through FGF receptor 2 is required in airway basal stem cells for self-renewing divisions and differentiation. This pathway maintains homeostasis in the adult airway epithelium, and may be at fault in cancer or degenerative disease.

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Epigenetic memory inhibits reprogramming in nuclear transfer

Hormanseder et al. in the Gurdon group show that nuclear transfer embryos retain the memory of a past state of active gene transcription. This can be countered by demethylation treatment, which thereby improves the efficiency of nuclear transfer and successful development of embryos.

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New cellular mechano-sensing mechanism

Edouard Hannezo from the Simons group, with colleagues from Institut Curie, show that neighbouring cells take an active part in each cell division. By combining fly genetics and live-imaging with biophysical modelling, they have discovered a new mechanism that allows forces to be sensed and transmitted from one cell to another.

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We're recruiting postdocs!

Several group leaders are seeking applications for postdoc positions. Come and join our world-leading scientists and enjoy the many benefits of postdoc life in Cambridge.

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Next in the Gurdon Institute Seminar Series

Coming up on Tuesday 25th April 2017, we welcome James Sharpe (Centre for Genomic Regulation, Barcelona, Spain) to talk about 'Multi-scale models of organogenesis: Limb bud development'. All welcome.

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Newly released video: Meet Andrea Brand

Andrea describes her research on neural stem cells in the final instalment of our series of ten group leader videos.

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Studying development to understand disease

The Gurdon Institute is funded by the Wellcome Trust and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

 

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