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Congratulations for Steve Jackson's Heineken Prize

The Royal Netherlands Academy of Arts and Sciences has awarded Professor Steve Jackson, head of Cancer Research UK Laboratories at the Gurdon Institute, the 2016 Dr A.H. Heineken Prize for Medicine. This international prize of $200,000 is in recognition of his "fundamental contributions to our understanding of the repair of DNA in human cells and for turning this knowledge into the development of new cancer drugs."

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Cells compete by squeezing their neighbours to death

The Gurdon Institute's Piddini lab publish a study showing that cells compete for space by squeezing neighbouring cells to death, so that fitter cells make room for their own expansion. Cell competition had previously been understood to depend on biochemical signals, so this 'mechanical cell competition' is a new mechanism, that may also be a tactic used by rapidly dividing cancer cells.

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Efficient CRISPR edits with minimal off-target effects

From Steve Jackson's group: a new method that combines an All-in-One Cas9D10A nickase vector with FACS enrichment followed by high-throughput genotypic and phenotypic clonal screening strategies to generate isogenic knockouts and knock-ins highly efficiently, with minimal off-target effects.

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Active signalling via FGFR1 prevents proliferation in airway epithelium

The Gurdon Institute's Rawlins lab identify an active signalling mechanism that maintains quiescence and prevents cell proliferation in the airway epithelium. An FGFR1-SPRY2 signalling axis had previously been characterised in cell lines in vitro and now the Rawlins lab demonstrate an in vivo biological function of this interaction.

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Gurdon Institute Seminar Series: next date 14th June 2016

Our next speaker will be Erez Lieberman Aiden (Baylor College of Medicine, Texas, USA) with a talk on 'Reading and writing genomes in 3D: The CTCF code and how to hack it', starting at 11.30am on Tuesday 14th June in the Biochemistry Lecture Theatre.

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Senior researcher competes with stem-cell culture business plan

Julia Tischler, Senior Research Associate in Azim Surani's lab, reached the finals of the first-ever Cambridge Postdoc Enterprise Competition with her business plan for a spinout company to offer microfluidic stem-cell culture solutions.

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Eugenia Piddini: from Sicily to stressed cells, via snorkelling

The Journal of Cell Biology interviews Gurdon Institute group leader Eugenia Piddini about the course of her scientific career and how her ground-breaking research direction came out of an unexpected experimental result.

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Studying development to understand disease

The Gurdon Institute is funded by the Wellcome Trust and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.