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Modelling transcription factor networks with software

Namshik Han from the Kouzarides lab, with Manchester colleagues, has developed a computational approach to identifying new members of transcription factor networks and new interactions between members. The authors are offering the software to others researching the regulation of gene transcription.

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The origin of human germ cells pinpointed with new pig model

The Surani lab, with Cambridge and Nottingham colleagues, enable new insights into early human development by using pig embryos and human stem cells to simulate human embryo development, and pinpoint the origin of primordial germ cells.

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A spectrum of pluripotent states in embryonic stem cells

The Surani lab show that embryonic stem cells, which can generate all cell lineages in the developing embryo, can be coaxed into a spectrum of many pluripotent states. This influences their response to differentiation and could be relevant for their future therapeutic use.

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Analysing the diversity of RNA modifications

The Miska lab, with Chemistry’s Balasubramanian lab and other colleagues, use a suite of chemical techniques to analyse the complete C. elegans transcriptome (i.e. all the species of RNA molecules) for modifications, and then track how these respond to the environmental stressors of heat or starvation.

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Three kinases at the heart of the DNA-damage response

Steve Jackson and former postdoc Andrew Blackford provide a historical perspective on the discovery of three related kinases, ATM, ATR and DNA-PK, and examine their structural similarities and models of regulation. Each plays a role in sensing and responding to DNA damage and may be a useful target in new disease therapies.

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Using lung organoids to study cell-cell interactions

Lung organoids have been grown successfully from human embryonic lungs, mouse and human adult lungs and human stem cell-derived lung progenitors. In this review, Marko Nikolic and Emma Rawlins evaluate their current widespread use for studying interactions between different cell types, to understand the growth requirements of each stem cell population during development and regeneration.

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See you at Fun Lab on the BIG Weekend!

Come and meet us in the Fun Lab tent on Parker's Piece 12-5pm on Saturday 8th July. We're running our popular 'Make and test your own microscope' activity - all you need to bring is your mobile phone.

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Studying development to understand disease

The Gurdon Institute is funded by Wellcome and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

 

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