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Cells compete by squeezing their neighbours to death

The Gurdon Institute's Piddini lab publish a study showing that cells compete for space by squeezing neighbouring cells to death, so that fitter cells make room for their own expansion. Cell competition had previously been understood to depend on biochemical signals, so this 'mechanical cell competition' is a new mechanism, that may also be a tactic used by rapidly dividing cancer cells.

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Efficient CRISPR edits with minimal off-target effects

From Steve Jackson's group: a new method that combines an All-in-One Cas9D10A nickase vector with FACS enrichment followed by high-throughput genotypic and phenotypic clonal screening strategies to generate isogenic knockouts and knock-ins highly efficiently, with minimal off-target effects.

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Active signalling via FGFR1 prevents proliferation in airway epithelium

The Gurdon Institute's Rawlins lab identify an active signalling mechanism that maintains quiescence and prevents cell proliferation in the airway epithelium. An FGFR1-SPRY2 signalling axis had previously been characterised in cell lines in vitro and now the Rawlins lab demonstrate an in vivo biological function of this interaction.

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Modelling primate cortex development in vitro

The Livesey lab at the Gurdon Institute, along with co-authors at the Salk Institute, have used 2D and 3D stem cell models of primate cortex development to show how final brain size is influenced by species-specific neuronal cues.

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Gurdon Institute Seminar Series: next date 10th May 2016

Our next speaker will be Konrad Hochedlinger (Harvard University, USA), with a talk titled: 'Understanding and manipulating cell fate', starting at 11.30am on Tuesday 10th May in the Biochemistry Lecture Theatre.

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Model organisms engage the public at CSF 2016

The Gurdon Institute was among many research stalls entertaining thousands of visitors at the Cambridge Science Festival hands-on event at the city's Guildhall on 12th and 13th March. With a theme of 'model organisms in research' we presented information and lots of worm, fly and frog specimens to handle and view under microscopes.

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What happens when artists visit the lab?

For 'Sketchcrawl', part of the Pint of Science festival activities, we invited three artists into the Gurdon Institute for half a day each in March 2016. Here are some of the results....

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Studying development to understand disease

The Gurdon Institute is funded by the Wellcome Trust and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.