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Two conserved Cdc20 binding motifs essential in mitotic checkpoint

The Pines lab demonstrate how two sequences in protein BubR1 of the Mitotic Checkpoint Complex (MCC) bind to Cdc20 and are required for the MCC to bind and inhibit the Anaphase Promoting Complex/Cyclosome. This is a key role in preventing replicated chromosomes from segregating incorrectly when cells divide, and the sequences are highly conserved throughout evolution.

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Gurdon Institute's Centre status secured

We are delighted to announce that the Wellcome Trust have renewed our core funding, enabling us to maintain our Wellcome Centre status for a further five years. The core funding allows us to bring together diverse but complementary research groups in cancer biology and developmental biology to share facilities, collaborate, and benefit from a dynamic research, cultural and training environment.

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Meri Huch wins Hamdan Award for Medical Research Excellence

Gurdon Institute Group Leader Meri Huch has just been announced as one of the winners of the Sheikh Hamdan bin Rashid al Maktoum Awards for Medical Sciences, 2015-2016. Her prize will be presented at a ceremony in Dubai, United Arab Emirates, in December, and is for her "innovative methods and research" on liver disorders.

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New synthetic-lethal pair in the DNA damage response

Exploring the role of recently discovered PAXX, a factor in the cellular pathway that repairs DNA double-strand breaks, the Jackson group and colleagues show that loss of PAXX in combination with loss of XLF in mice is a lethal combination despite the mild health effects that result from loss of either factor alone.

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Piddini secures Wellcome SRF

Congratulations to Group Leader Eugenia Piddini on being awarded a Senior Research Fellowship from Wellcome. This will allow her to build on her exciting discoveries on cell competition, and to investigate how these phenomena could be harnessed for therapeutic strategies in regenerative medicine and cancer.

More about research in the Piddini lab

Surani lab postdoc appears on air

Dr Maud Borensztein answers science questions from the public, such as 'How much does a cell weigh?' and 'What would happen if you incubated a double yolk egg?' in this podcast from the Naked Scientists. The programme will also air on BBC radio's '5 live Science' and Australia's ABC Radio National in the coming days.

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Our former Director to be knighted

Congratulations to Jim Smith, Director of the Gurdon Institute from October 2001 to December 2008, who received a knighthood in the 2017 Queen's New Year's Honours list. Jim is the newly appointed Director of Science at Wellcome, and previously Director of Research at the Francis Crick Institute, all of which is good news for our mutual research area of developmental biology.

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Studying development to understand disease

The Gurdon Institute is funded by the Wellcome Trust and Cancer Research UK to study the biology of development, and how normal growth and maintenance go wrong in cancer and other diseases.

 

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