St Johnston

The simple layer of epithelial cells in the fruit fly midgut, with intestinal stem cells (ISC, smaller cells) situating at the basal side. Nuclear in cyan, alpha-Spectrin (cell cortical region) in magenta, and occluding septate junction in yellow.
Publication - St Johnston

How polarised epithelial cells grow “up” without breaking the barrier

Similarities between fly midgut polarisation and lumen formation in mammalian epithelial cysts

September 28, 2022

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Photo of drawer full of metal microscope components
Publication - St Johnston

Optimising spinning disk microscopy for imaging with PAINT

Spinning disk geometries with higher light collection efficiency prove best for PAINT-based imaging

June 7, 2022

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Publication - St Johnston

Unexpected clustering of nuclear pores revealed by new tissue imaging system

Single-molecule localisation microscopy in tissues reveals non-random distribution of nuclear pores

December 16, 2021

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Fly vials in St Johnston lab
Publication - St Johnston

Polarity axes in Drosophila

Doerflinger et al. establish role of myosin in setting up oocyte polarity

December 1, 2021

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Fly sorting in St Johnston lab
Publication - St Johnston

Breaking symmetry to establish oocyte identity

St Johnston lab show that Patronin/CAMSAP marks the future Drosophila oocyte

November 11, 2021

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