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Anne McLaren colour portrait
News

Remembering Anne McLaren

A new biographical memoir free to read and download.

March 20, 2023

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16 weeks post-conception human fetal lung. The branching airway tree is surrounded by bands of developing smooth muscle (green), which also labels the developing vasculature. The epithelial progenitor cells (co expressing SFTPC in white and NOTUM in red) are initiating the process of alveolar epithelial development. Image supplied by co-author Emma Rawlins (University of Cambridge), image credit Dr Kyungtae Lim.
Publication - Rawlins

Biggest leap in identified lung health genes paves way for personalised risk score

Over 500 new genes have been linked to lung function for the first time

March 13, 2023

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A 3D reconstructed tree of a murine salivary gland lobe showing clones resulting from labelling of individual progenitors that were traced from an early to a final stage of branching morphogenesis.
Publication - Simons

Tracing lineage restriction and patterning during branching morphogenesis

Understanding branching morphogenesis

January 23, 2023

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Human foetal lung stained to show epithelial cell outlines.
Publication - Rawlins

Control of cell shape in the developing human lung epithelium

Building the lung

May 23, 2023

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Publication - Xiong

A new method for measuring and exerting forces on the developing chicken embryo

Measuring and exerting forces on the avian embryo

May 1, 2023

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16 weeks post-conception human fetal lung. The branching airway tree is surrounded by bands of developing smooth muscle (green), which also labels the developing vasculature. The epithelial progenitor cells (co expressing SFTPC in white and NOTUM in red) are initiating the process of alveolar epithelial development. Image supplied by co-author Emma Rawlins (University of Cambridge), image credit Dr Kyungtae Lim.
Publication - Rawlins

Biggest leap in identified lung health genes paves way for personalised risk score

Over 500 new genes have been linked to lung function for the first time

March 13, 2023

Read more
A 3D reconstructed tree of a murine salivary gland lobe showing clones resulting from labelling of individual progenitors that were traced from an early to a final stage of branching morphogenesis.
Publication - Simons

Tracing lineage restriction and patterning during branching morphogenesis

Understanding branching morphogenesis

January 23, 2023

Read more
Immunostaining of a human female genital ridge in the 8th week of embryonic development depicting levels of H3K4me1 (red) and POU5F1 (green) in gonadal somatic cells and primordial germ cells (PGCs). Note that POU5F1-positive PGCs exhibit higher H3K4me1 levels than the surrounding somatic cells.
Publication - Surani

Human germline rejuvenation entails heterochromatin remodelling

Reduced levels of repressive histone modifications in reset hPGCs

January 18, 2023

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Human primordial germ cell-like cells (yellow) co-cultured with human hindgut organoids (magenta/cyan).
Publication - Surani

Human primordial germ cell-like cell development in hindgut organoids

Different precursors impact human primordial germ cell-like cell development.

January 5, 2023

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C. elegans adult germline expressing a GFP construct. The specific expression of the construct was driven by a TE-co-opted promoter.
Publication - Ahringer

Transposable elements recruited as promoters in the Caenorhabditis germline

Transposon co-option in the Caenorhabditis germline

December 16, 2022

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Rawlins group_Human fetal lung tissue staining image showing alveolar development
Publication - Rawlins

Novel human lung organoids to study development and disease

Building the human lung

December 8, 2022

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Rawlins group_Human fetal lung tissue staining image describing a signalling niche for airway development
Publication - Rawlins

Human fetal lung cell atlas released

Single-cell lung atlas will provide foundational dataset

December 8, 2022

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