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Germinal vesicles dissected from Xenopus meiotic oocytes containing potent factors to reprogram somatic cell nuclei.
Publication - Gurdon

Unlocking the potential for clinical application of reprogrammed somatic cells by germinal vesicles from Xenopus meiotic oocytes

March 1, 2024

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Fly vials in St Johnston lab
Publication - St Johnston

Spectraplakin binds a specific type of actin during oocyte fate formation

April 2, 2024

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A specimen illuminated by fluorescent light on microscope stage in St Johnston lab
Publication - St Johnston

Implementation of a two-mirror scanning system enables fast volumetric imaging with a tilted light-sheet produced by a single objective on a fully functional commercial microscope base

March 15, 2024

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Publication - Simons

Self-tuning of plasma cell lifespan by competition controls humoral immune memory

March 5, 2024

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Steve Jackson
News - Jackson

Steve Jackson awarded a knighthood for his services to innovation and research

Steve's achievements recognised in the King's first birthday honours list

June 17, 2023

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Cross-section of a chicken embryo body axis
Publication - Xiong

Environmental forces control embryonic development

New link between extraembryonic mechanics to embryo

June 5, 2023

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Human foetal lung stained to show epithelial cell outlines.
Publication - Rawlins

Control of cell shape in the developing human lung epithelium

Building the lung

May 23, 2023

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Microinjector on microscope stage from Surani lab
Publication - Surani

Tracing the origin and segregation of the human germline

Elucidating the precursors of the human germline in gastrulating embryos

May 22, 2023

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Publication - Xiong

A new method for measuring and exerting forces on the developing chicken embryo

Measuring and exerting forces on the avian embryo

May 1, 2023

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Anne McLaren colour portrait
News

Remembering Anne McLaren

A new biographical memoir free to read and download.

March 20, 2023

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16 weeks post-conception human fetal lung. The branching airway tree is surrounded by bands of developing smooth muscle (green), which also labels the developing vasculature. The epithelial progenitor cells (co expressing SFTPC in white and NOTUM in red) are initiating the process of alveolar epithelial development. Image supplied by co-author Emma Rawlins (University of Cambridge), image credit Dr Kyungtae Lim.
Publication - Rawlins

Biggest leap in identified lung health genes paves way for personalised risk score

Over 500 new genes have been linked to lung function for the first time

March 13, 2023

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A 3D reconstructed tree of a murine salivary gland lobe showing clones resulting from labelling of individual progenitors that were traced from an early to a final stage of branching morphogenesis.
Publication - Simons

Tracing lineage restriction and patterning during branching morphogenesis

Understanding branching morphogenesis

January 23, 2023

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Immunostaining of a human female genital ridge in the 8th week of embryonic development depicting levels of H3K4me1 (red) and POU5F1 (green) in gonadal somatic cells and primordial germ cells (PGCs). Note that POU5F1-positive PGCs exhibit higher H3K4me1 levels than the surrounding somatic cells.
Publication - Surani

Human germline rejuvenation entails heterochromatin remodelling

Reduced levels of repressive histone modifications in reset hPGCs

January 18, 2023

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